SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ybw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y7I_A_SALA502_1
(SALICYLIC
ACID-BINDING PROTEIN
2)		 1ybw HEPATOCYTE GROWTH
FACTOR ACTIVATOR
PRECURSOR
(Homo
sapiens) 		3 / 3 LEU A 625
HIS A 626
LYS A 627
 None
 1.06A 1y7iA-1ybwA:
undetectable		 1y7iA-1ybwA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HC4_A_VDXA525_2
(VITAMIN D RECEPTOR)		 1ybw HEPATOCYTE GROWTH
FACTOR ACTIVATOR
PRECURSOR
(Homo
sapiens) 		4 / 7 LEU A 612
LEU A 602
ILE A 408
SER A 591
 None
 0.91A 2hc4A-1ybwA:
undetectable		 2hc4A-1ybwA:
22.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2P16_A_GG2A298_1
(COAGULATION FACTOR X
(EC 3.4.21.6)
(STUART FACTOR)
(STUART-PROWER
FACTOR))		 1ybw HEPATOCYTE GROWTH
FACTOR ACTIVATOR
PRECURSOR
(Homo
sapiens) 		6 / 12 ASP A 592
ALA A 593
CYH A 594
SER A 598
GLY A 629
TYR A 631
 None
 0.99A 2p16A-1ybwA:
31.7		 2p16A-1ybwA:
33.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W26_A_RIVA1001_1
(ACTIVATED FACTOR XA
HEAVY CHAIN)		 1ybw HEPATOCYTE GROWTH
FACTOR ACTIVATOR
PRECURSOR
(Homo
sapiens) 		5 / 12 ASP A 592
ALA A 593
SER A 598
CYH A 622
TYR A 631
 None
 0.77A 2w26A-1ybwA:
31.8		 2w26A-1ybwA:
33.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W26_A_RIVA1001_1
(ACTIVATED FACTOR XA
HEAVY CHAIN)		 1ybw HEPATOCYTE GROWTH
FACTOR ACTIVATOR
PRECURSOR
(Homo
sapiens) 		5 / 12 ASP A 592
ALA A 593
SER A 598
GLY A 629
TYR A 631
 None
 0.68A 2w26A-1ybwA:
31.8		 2w26A-1ybwA:
33.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9F_F_LFXF0_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 1ybw HEPATOCYTE GROWTH
FACTOR ACTIVATOR
PRECURSOR
(Homo
sapiens) 		4 / 5 SER A 494
ARG A 624
GLY A 621
GLU A 545
 None
 1.05A 3k9fA-1ybwA:
undetectable
3k9fB-1ybwA:
undetectable
3k9fC-1ybwA:
undetectable		 3k9fA-1ybwA:
19.01
3k9fB-1ybwA:
19.01
3k9fC-1ybwA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9F_H_LFXH0_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 1ybw HEPATOCYTE GROWTH
FACTOR ACTIVATOR
PRECURSOR
(Homo
sapiens) 		4 / 6 SER A 494
ARG A 624
GLY A 621
GLU A 545
 None
 1.05A 3k9fA-1ybwA:
undetectable
3k9fB-1ybwA:
undetectable
3k9fD-1ybwA:
undetectable		 3k9fA-1ybwA:
19.01
3k9fB-1ybwA:
19.01
3k9fD-1ybwA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PRS_A_RITA1001_2
(ENDOTHIAPEPSIN)		 1ybw HEPATOCYTE GROWTH
FACTOR ACTIVATOR
PRECURSOR
(Homo
sapiens) 		5 / 12 GLY A 541
GLY A 621
ASP A 597
TYR A 631
ILE A 616
 None
 1.10A 3prsA-1ybwA:
undetectable		 3prsA-1ybwA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DT8_A_ADNA401_1
(APH(2'')-ID)		 1ybw HEPATOCYTE GROWTH
FACTOR ACTIVATOR
PRECURSOR
(Homo
sapiens) 		5 / 11 SER A 444
GLY A 599
ALA A 445
PRO A 453
ILE A 427
 None
 1.04A 4dt8A-1ybwA:
undetectable		 4dt8A-1ybwA:
20.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FU8_A_ACTA302_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 1ybw HEPATOCYTE GROWTH
FACTOR ACTIVATOR
PRECURSOR
(Homo
sapiens) 		4 / 5 HIS A 447
GLN A 595
GLY A 596
SER A 598
 None
 0.72A 4fu8A-1ybwA:
34.4		 4fu8A-1ybwA:
38.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FU8_A_ACTA302_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 1ybw HEPATOCYTE GROWTH
FACTOR ACTIVATOR
PRECURSOR
(Homo
sapiens) 		4 / 5 HIS A 447
TYR A 550
GLY A 596
SER A 598
 None
NAG  A 741 ( 4.8A)
None
None
 0.72A 4fu8A-1ybwA:
34.4		 4fu8A-1ybwA:
38.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R3A_B_RBFB402_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 1ybw HEPATOCYTE GROWTH
FACTOR ACTIVATOR
PRECURSOR
(Homo
sapiens) 		5 / 12 ALA A 584
LEU A 561
ALA A 538
ILE A 537
ILE A 520
 None
 0.99A 4r3aB-1ybwA:
undetectable		 4r3aB-1ybwA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z3O_F_MFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT
B,PARE30-PARC55
FUSED TOPO IV FROM
S. PNEUMONIAE
E-SITE DNA)		 1ybw HEPATOCYTE GROWTH
FACTOR ACTIVATOR
PRECURSOR
(Homo
sapiens) 		4 / 5 ARG A 624
GLY A 621
GLU A 545
SER A 494
 None
 0.91A 4z3oA-1ybwA:
undetectable
4z3oB-1ybwA:
undetectable		 4z3oA-1ybwA:
18.91
4z3oB-1ybwA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_A_RBVA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 1ybw HEPATOCYTE GROWTH
FACTOR ACTIVATOR
PRECURSOR
(Homo
sapiens) 		3 / 3 THR A 632
HIS A 438
LEU A 522
 None
 0.66A 5axdA-1ybwA:
undetectable		 5axdA-1ybwA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_C_RBVC502_2
(ADENOSYLHOMOCYSTEINA
SE)		 1ybw HEPATOCYTE GROWTH
FACTOR ACTIVATOR
PRECURSOR
(Homo
sapiens) 		3 / 3 THR A 632
HIS A 438
LEU A 522
 None
 0.65A 5axdC-1ybwA:
undetectable		 5axdC-1ybwA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 1ybw HEPATOCYTE GROWTH
FACTOR ACTIVATOR
PRECURSOR
(Homo
sapiens) 		5 / 12 ILE A 537
ALA A 538
GLY A 621
SER A 598
GLY A 585
 None
 1.08A 5i75A-1ybwA:
undetectable		 5i75A-1ybwA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 1ybw HEPATOCYTE GROWTH
FACTOR ACTIVATOR
PRECURSOR
(Homo
sapiens) 		5 / 12 ILE A 616
GLY A 619
TYR A 631
ALA A 584
SER A 412
 None
 0.93A 5igvA-1ybwA:
undetectable		 5igvA-1ybwA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQ4_A_ADNA401_1
(THERMOSPERMINE
SYNTHASE ACAULIS
PROTEIN)		 1ybw HEPATOCYTE GROWTH
FACTOR ACTIVATOR
PRECURSOR
(Homo
sapiens) 		6 / 12 GLY A 541
ILE A 409
ASP A 544
VAL A 547
ASP A 592
ALA A 593
 None
 1.31A 6bq4A-1ybwA:
undetectable		 6bq4A-1ybwA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQ4_B_ADNB401_1
(THERMOSPERMINE
SYNTHASE ACAULIS
PROTEIN)		 1ybw HEPATOCYTE GROWTH
FACTOR ACTIVATOR
PRECURSOR
(Homo
sapiens) 		6 / 12 GLY A 541
ILE A 409
ASP A 544
VAL A 547
ASP A 592
ALA A 593
 None
 1.32A 6bq4B-1ybwA:
undetectable		 6bq4B-1ybwA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CK2_C_IPHC101_0
(INSULIN A CHAIN
INSULIN B CHAIN)		 1ybw HEPATOCYTE GROWTH
FACTOR ACTIVATOR
PRECURSOR
(Homo
sapiens) 		4 / 4 ILE A 501
LEU A 462
HIS A 438
ALA A 511
 None
 0.91A 6ck2C-1ybwA:
undetectable
6ck2D-1ybwA:
undetectable		 6ck2C-1ybwA:
7.11
6ck2D-1ybwA:
7.69