SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1yby'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1IGX_A_EPAA700_2 (PROSTAGLANDIN ENDOPEROXIDE H SYNTHASE-1)	1yby	TRANSLATION ELONGATION FACTOR P (Ruminiclostridiu m thermocellum)	4 / 8	VAL A 111 VAL A 113 SER A 115 LEU A 93	None	0.92A	1igxA-1ybyA: undetectable	1igxA-1ybyA: 16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3HS6_B_EPAB1_2 (PROSTAGLANDIN G/H SYNTHASE 2)	1yby	TRANSLATION ELONGATION FACTOR P (Ruminiclostridiu m thermocellum)	4 / 7	VAL A 111 VAL A 113 LEU A 114 SER A 115	None	0.81A	3hs6B-1ybyA: undetectable	3hs6B-1ybyA: 15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4A6E_A_SAMA1349_1 (HYDROXYINDOLE O-METHYLTRANSFERASE)	1yby	TRANSLATION ELONGATION FACTOR P (Ruminiclostridiu m thermocellum)	3 / 3	TYR A 81 ASP A 78 ASP A 96	None	0.84A	4a6eA-1ybyA: undetectable	4a6eA-1ybyA: 21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5VKQ_A_PCFA1805_0 (NO MECHANORECEPTOR POTENTIAL C ISOFORM L)	1yby	TRANSLATION ELONGATION FACTOR P (Ruminiclostridiu m thermocellum)	5 / 7	PHE A 104 VAL A 129 PRO A 125 ILE A 123 THR A 176	None	1.30A	5vkqA-1ybyA: undetectable 5vkqD-1ybyA: undetectable	5vkqA-1ybyA: 8.44 5vkqD-1ybyA: 8.44

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1IGX_A_EPAA700_2","PROSTAGLANDIN ENDOPEROXIDE H SYNTHASE-1","1yby","TRANSLATION ELONGATION FACTOR P","Ruminiclostridium thermocellum",4,"VAL A 111;VAL A 113;SER A 115;LEU A  93","None","0.92A","1igxA-1ybyA:undetectable","1igxA-1ybyA:16.52"],["3HS6_B_EPAB1_2","PROSTAGLANDIN G\/H SYNTHASE 2","1yby","TRANSLATION ELONGATION FACTOR P","Ruminiclostridium thermocellum",4,"VAL A 111;VAL A 113;LEU A 114;SER A 115","None","0.81A","3hs6B-1ybyA:undetectable","3hs6B-1ybyA:15.71"],["4A6E_A_SAMA1349_1","HYDROXYINDOLE O-METHYLTRANSFERASE","1yby","TRANSLATION ELONGATION FACTOR P","Ruminiclostridium thermocellum",3,"TYR A  81;ASP A  78;ASP A  96","None","0.84A","4a6eA-1ybyA:undetectable","4a6eA-1ybyA:21.57"],["5VKQ_A_PCFA1805_0","NO MECHANORECEPTOR POTENTIAL C ISOFORM L","1yby","TRANSLATION ELONGATION FACTOR P","Ruminiclostridium thermocellum",5,"PHE A 104;VAL A 129;PRO A 125;ILE A 123;THR A 176","None","1.30A","5vkqA-1ybyA:undetectable;5vkqD-1ybyA:undetectable","5vkqA-1ybyA:8.44;5vkqD-1ybyA:8.44"]]