SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1yc9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A29_A_TFPA154_1
(CALMODULIN)		 1yc9 MULTIDRUG RESISTANCE
PROTEIN
(Vibrio
cholerae) 		5 / 10 GLU A 448
GLU A 447
ALA A 446
LEU A 426
GLU A 247
 None
 1.28A 1a29A-1yc9A:
undetectable		 1a29A-1yc9A:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMA_B_SAMB105_0
(PROTEIN (MET
REPRESSOR))		 1yc9 MULTIDRUG RESISTANCE
PROTEIN
(Vibrio
cholerae) 		5 / 11 ARG A 310
GLU A 177
ALA A 101
PHE A 104
GLY A 103
 None
 1.33A 1cmaA-1yc9A:
undetectable
1cmaB-1yc9A:
undetectable		 1cmaA-1yc9A:
13.38
1cmaB-1yc9A:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMA_B_SAMB105_0
(PROTEIN (MET
REPRESSOR))		 1yc9 MULTIDRUG RESISTANCE
PROTEIN
(Vibrio
cholerae) 		5 / 11 GLU A 170
ARG A 310
GLU A 177
ALA A 101
GLY A 103
 None
 1.17A 1cmaA-1yc9A:
undetectable
1cmaB-1yc9A:
undetectable		 1cmaA-1yc9A:
13.38
1cmaB-1yc9A:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMC_A_SAMA105_0
(MET REPRESSOR)		 1yc9 MULTIDRUG RESISTANCE
PROTEIN
(Vibrio
cholerae) 		5 / 10 ALA A 101
GLY A 103
GLU A 170
ARG A 310
GLU A 177
 None
 1.12A 1cmcA-1yc9A:
undetectable
1cmcB-1yc9A:
undetectable		 1cmcA-1yc9A:
13.38
1cmcB-1yc9A:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMC_A_SAMA105_0
(MET REPRESSOR)		 1yc9 MULTIDRUG RESISTANCE
PROTEIN
(Vibrio
cholerae) 		5 / 10 ALA A 101
PHE A 104
GLY A 103
ARG A 310
GLU A 177
 None
 1.32A 1cmcA-1yc9A:
undetectable
1cmcB-1yc9A:
undetectable		 1cmcA-1yc9A:
13.38
1cmcB-1yc9A:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMC_B_SAMB105_0
(MET REPRESSOR)		 1yc9 MULTIDRUG RESISTANCE
PROTEIN
(Vibrio
cholerae) 		5 / 10 ARG A 310
GLU A 177
ALA A 101
PHE A 104
GLY A 103
 None
 1.38A 1cmcA-1yc9A:
undetectable
1cmcB-1yc9A:
undetectable		 1cmcA-1yc9A:
13.38
1cmcB-1yc9A:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMC_B_SAMB105_0
(MET REPRESSOR)		 1yc9 MULTIDRUG RESISTANCE
PROTEIN
(Vibrio
cholerae) 		5 / 10 GLU A 170
ARG A 310
GLU A 177
ALA A 101
GLY A 103
 None
 1.12A 1cmcA-1yc9A:
undetectable
1cmcB-1yc9A:
undetectable		 1cmcA-1yc9A:
13.38
1cmcB-1yc9A:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KXH_A_ACRA598_2
(ALPHA-AMYLASE)		 1yc9 MULTIDRUG RESISTANCE
PROTEIN
(Vibrio
cholerae) 		3 / 3 TRP A  69
TYR A 193
LEU A 469
 None
 0.96A 1kxhA-1yc9A:
undetectable		 1kxhA-1yc9A:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_A_SAMA2200_0
(PROTEIN (METHIONINE
REPRESSOR))		 1yc9 MULTIDRUG RESISTANCE
PROTEIN
(Vibrio
cholerae) 		5 / 12 ALA A 101
GLY A 103
GLU A 170
ARG A 310
GLU A 177
 None
 1.06A 1mj2A-1yc9A:
undetectable
1mj2B-1yc9A:
undetectable		 1mj2A-1yc9A:
13.62
1mj2B-1yc9A:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_C_SAMC2199_0
(PROTEIN (METHIONINE
REPRESSOR))		 1yc9 MULTIDRUG RESISTANCE
PROTEIN
(Vibrio
cholerae) 		5 / 12 ALA A 101
GLY A 103
GLU A 170
ARG A 310
GLU A 177
 None
 1.09A 1mj2C-1yc9A:
undetectable
1mj2D-1yc9A:
undetectable		 1mj2C-1yc9A:
13.62
1mj2D-1yc9A:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_C_SAMC200_0
(METHIONINE REPRESSOR)		 1yc9 MULTIDRUG RESISTANCE
PROTEIN
(Vibrio
cholerae) 		5 / 12 ALA A 101
GLY A 103
GLU A 170
ARG A 310
GLU A 177
 None
 1.07A 1mjoC-1yc9A:
undetectable
1mjoD-1yc9A:
undetectable		 1mjoC-1yc9A:
13.62
1mjoD-1yc9A:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_A_SAMA200_0
(METHIONINE REPRESSOR)		 1yc9 MULTIDRUG RESISTANCE
PROTEIN
(Vibrio
cholerae) 		5 / 11 ARG A 310
GLU A 177
ALA A 101
PHE A 104
GLY A 103
 None
 1.35A 1mjqA-1yc9A:
undetectable
1mjqB-1yc9A:
undetectable		 1mjqA-1yc9A:
13.62
1mjqB-1yc9A:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_A_SAMA200_0
(METHIONINE REPRESSOR)		 1yc9 MULTIDRUG RESISTANCE
PROTEIN
(Vibrio
cholerae) 		5 / 11 GLU A 170
ARG A 310
GLU A 177
ALA A 101
GLY A 103
 None
 1.10A 1mjqA-1yc9A:
undetectable
1mjqB-1yc9A:
undetectable		 1mjqA-1yc9A:
13.62
1mjqB-1yc9A:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_C_SAMC199_0
(METHIONINE REPRESSOR)		 1yc9 MULTIDRUG RESISTANCE
PROTEIN
(Vibrio
cholerae) 		5 / 10 ARG A 310
GLU A 177
ALA A 101
PHE A 104
GLY A 103
 None
 1.39A 1mjqC-1yc9A:
undetectable
1mjqD-1yc9A:
undetectable		 1mjqC-1yc9A:
13.62
1mjqD-1yc9A:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_C_SAMC199_0
(METHIONINE REPRESSOR)		 1yc9 MULTIDRUG RESISTANCE
PROTEIN
(Vibrio
cholerae) 		5 / 10 GLU A 170
ARG A 310
GLU A 177
ALA A 101
GLY A 103
 None
 1.11A 1mjqC-1yc9A:
undetectable
1mjqD-1yc9A:
undetectable		 1mjqC-1yc9A:
13.62
1mjqD-1yc9A:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_D_SAMD200_0
(METHIONINE REPRESSOR)		 1yc9 MULTIDRUG RESISTANCE
PROTEIN
(Vibrio
cholerae) 		5 / 12 ALA A 101
GLY A 103
GLU A 170
ARG A 310
GLU A 177
 None
 1.05A 1mjqC-1yc9A:
undetectable
1mjqD-1yc9A:
undetectable		 1mjqC-1yc9A:
13.62
1mjqD-1yc9A:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_G_SAMG199_0
(METHIONINE REPRESSOR)		 1yc9 MULTIDRUG RESISTANCE
PROTEIN
(Vibrio
cholerae) 		5 / 10 GLU A 170
ARG A 310
GLU A 177
ALA A 101
GLY A 103
 None
 1.09A 1mjqG-1yc9A:
undetectable
1mjqH-1yc9A:
undetectable		 1mjqG-1yc9A:
13.62
1mjqH-1yc9A:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_G_SAMG199_0
(METHIONINE REPRESSOR)		 1yc9 MULTIDRUG RESISTANCE
PROTEIN
(Vibrio
cholerae) 		5 / 10 GLU A 177
ALA A 174
ALA A 101
PHE A 104
GLY A 103
 None
 1.20A 1mjqG-1yc9A:
undetectable
1mjqH-1yc9A:
undetectable		 1mjqG-1yc9A:
13.62
1mjqH-1yc9A:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_I_SAMI199_0
(METHIONINE REPRESSOR)		 1yc9 MULTIDRUG RESISTANCE
PROTEIN
(Vibrio
cholerae) 		5 / 11 GLU A 170
ARG A 310
GLU A 177
ALA A 101
GLY A 103
 None
 1.10A 1mjqI-1yc9A:
undetectable
1mjqJ-1yc9A:
undetectable		 1mjqI-1yc9A:
13.62
1mjqJ-1yc9A:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_J_SAMJ200_0
(METHIONINE REPRESSOR)		 1yc9 MULTIDRUG RESISTANCE
PROTEIN
(Vibrio
cholerae) 		5 / 12 ALA A 101
GLY A 103
GLU A 170
ARG A 310
GLU A 177
 None
 1.05A 1mjqI-1yc9A:
undetectable
1mjqJ-1yc9A:
undetectable		 1mjqI-1yc9A:
13.62
1mjqJ-1yc9A:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX8_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN I, HOLO)		 1yc9 MULTIDRUG RESISTANCE
PROTEIN
(Vibrio
cholerae) 		5 / 12 PHE A 465
LEU A 469
ALA A 194
PRO A 279
ILE A 189
 None
 1.21A 1mx8A-1yc9A:
undetectable		 1mx8A-1yc9A:
12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_B_SUEB1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 1yc9 MULTIDRUG RESISTANCE
PROTEIN
(Vibrio
cholerae) 		3 / 3 TYR A 200
LEU A 467
ARG A 198
 None
 0.71A 3sufB-1yc9A:
undetectable		 3sufB-1yc9A:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKX_A_198A1002_2
(ANDROGEN RECEPTOR)		 1yc9 MULTIDRUG RESISTANCE
PROTEIN
(Vibrio
cholerae) 		4 / 6 LEU A 257
ASN A 260
LEU A 199
ILE A 276
 None
 1.13A 4okxA-1yc9A:
undetectable		 4okxA-1yc9A:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AOX_C_ACTC1001_0
(ALU JO CONSENSUS RNA
SIGNAL RECOGNITION
PARTICLE 14 KDA
PROTEIN)		 1yc9 MULTIDRUG RESISTANCE
PROTEIN
(Vibrio
cholerae) 		3 / 3 TYR A 143
THR A 145
THR A 123
 None
 0.64A 5aoxB-1yc9A:
undetectable		 5aoxB-1yc9A:
10.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AOX_F_ACTF1001_0
(ALU JO CONSENSUS RNA
SIGNAL RECOGNITION
PARTICLE 14 KDA
PROTEIN)		 1yc9 MULTIDRUG RESISTANCE
PROTEIN
(Vibrio
cholerae) 		3 / 3 TYR A 143
THR A 145
THR A 123
 None
 0.68A 5aoxE-1yc9A:
undetectable		 5aoxE-1yc9A:
10.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1N_F_DVAF9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 1yc9 MULTIDRUG RESISTANCE
PROTEIN
(Vibrio
cholerae) 		3 / 3 ALA A 456
ASN A 459
LEU A 460
 None
 0.50A 5i1nC-1yc9A:
undetectable		 5i1nC-1yc9A:
5.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1P_G_DVAG9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 1yc9 MULTIDRUG RESISTANCE
PROTEIN
(Vibrio
cholerae) 		3 / 3 ALA A 456
ASN A 459
LEU A 460
 None
 0.50A 5i1pD-1yc9A:
undetectable		 5i1pD-1yc9A:
6.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G9B_B_IXXB705_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN
ENVELOPE
GLYCOPROTEIN)		 1yc9 MULTIDRUG RESISTANCE
PROTEIN
(Vibrio
cholerae) 		4 / 5 ALA A 197
TYR A 200
GLN A  76
ILE A 276
 None
 1.47A 6g9bA-1yc9A:
undetectable
6g9bB-1yc9A:
undetectable		 6g9bA-1yc9A:
10.45
6g9bB-1yc9A:
11.59