SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ycl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3EM0_B_CHDB151_0 (ILEAL BILE ACID-BINDING PROTEIN)	1ycl	S-RIBOSYLHOMOCYSTEIN ASE (Bacillus subtilis)	5 / 12	ILE A 79 ILE A 38 VAL A 19 LEU A 145 LEU A 56	KRI A 401 (-4.9A) None None None None	1.11A	3em0B-1yclA: 0.5	3em0B-1yclA: 22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4PEV_C_ADNC501_2 (MEMBRANE LIPOPROTEIN FAMILY PROTEIN)	1ycl	S-RIBOSYLHOMOCYSTEIN ASE (Bacillus subtilis)	3 / 3	PRO A 96 VAL A 24 HIS A 25	None	0.77A	4pevC-1yclA: undetectable	4pevC-1yclA: 18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4Y8W_C_STRC603_2 (CYTOCHROME P450 21-HYDROXYLASE)	1ycl	S-RIBOSYLHOMOCYSTEIN ASE (Bacillus subtilis)	3 / 3	LEU A 145 VAL A 102 ASP A 103	None	0.66A	4y8wC-1yclA: undetectable	4y8wC-1yclA: 19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5TUD_A_ERMA2001_2 (5-HYDROXYTRYPTAMINE RECEPTOR 2B,SOLUBLE CYTOCHROME B562 CHIMERA)	1ycl	S-RIBOSYLHOMOCYSTEIN ASE (Bacillus subtilis)	4 / 7	LEU A 140 LYS A 138 VAL A 113 GLU A 57	None None None KRI A 401 (-3.1A)	0.94A	5tudA-1yclA: 0.1	5tudA-1yclA: 15.84

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["3EM0_B_CHDB151_0","ILEAL BILE ACID-BINDING PROTEIN","1ycl","S-RIBOSYLHOMOCYSTEINASE","Bacillus subtilis",5,"ILE A  79;ILE A  38;VAL A  19;LEU A 145;LEU A  56","KRI A 401 (-4.9A);None;None;None;None","1.11A","3em0B-1yclA:0.5","3em0B-1yclA:22.09"],["4PEV_C_ADNC501_2","MEMBRANE LIPOPROTEIN FAMILY PROTEIN","1ycl","S-RIBOSYLHOMOCYSTEINASE","Bacillus subtilis",3,"PRO A  96;VAL A  24;HIS A  25","None","0.77A","4pevC-1yclA:undetectable","4pevC-1yclA:18.34"],["4Y8W_C_STRC603_2","CYTOCHROME P450 21-HYDROXYLASE","1ycl","S-RIBOSYLHOMOCYSTEINASE","Bacillus subtilis",3,"LEU A 145;VAL A 102;ASP A 103","None","0.66A","4y8wC-1yclA:undetectable","4y8wC-1yclA:19.14"],["5TUD_A_ERMA2001_2","5-HYDROXYTRYPTAMINE RECEPTOR 2B,SOLUBLE CYTOCHROME B562 CHIMERA","1ycl","S-RIBOSYLHOMOCYSTEINASE","Bacillus subtilis",4,"LEU A 140;LYS A 138;VAL A 113;GLU A  57","None;None;None;KRI A 401 (-3.1A)","0.94A","5tudA-1yclA:0.1","5tudA-1yclA:15.84"]]