SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ycn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OPJ_B_STIB4_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 1ycn PUTATIVE
CA2+-DEPENDENT
MEMBRANE-BINDING
PROTEIN ANNEXIN
(Arabidopsis
thaliana) 		4 / 6 LEU A 118
VAL A 279
ILE A 275
MET A 107
 None
 1.02A 1opjB-1ycnA:
undetectable		 1opjB-1ycnA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QVU_A_PRLA196_0
(TRANSCRIPTIONAL
REGULATOR QACR)		 1ycn PUTATIVE
CA2+-DEPENDENT
MEMBRANE-BINDING
PROTEIN ANNEXIN
(Arabidopsis
thaliana) 		4 / 6 LEU A 220
GLU A 222
TYR A 208
TYR A 184
 None
 1.27A 1qvuA-1ycnA:
2.1		 1qvuA-1ycnA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJT_A_SAMA501_1
(N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE)		 1ycn PUTATIVE
CA2+-DEPENDENT
MEMBRANE-BINDING
PROTEIN ANNEXIN
(Arabidopsis
thaliana) 		3 / 3 ARG A 196
ASP A 186
ASP A 181
 None
 0.62A 2ejtA-1ycnA:
undetectable		 2ejtA-1ycnA:
25.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_B_STIB600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 1ycn PUTATIVE
CA2+-DEPENDENT
MEMBRANE-BINDING
PROTEIN ANNEXIN
(Arabidopsis
thaliana) 		4 / 6 LEU A 118
VAL A 279
ILE A 275
MET A 107
 None
 1.02A 2hyyB-1ycnA:
undetectable		 2hyyB-1ycnA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_C_STIC600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 1ycn PUTATIVE
CA2+-DEPENDENT
MEMBRANE-BINDING
PROTEIN ANNEXIN
(Arabidopsis
thaliana) 		4 / 6 LEU A 118
VAL A 279
ILE A 275
MET A 107
 None
 1.06A 2hyyC-1ycnA:
undetectable		 2hyyC-1ycnA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_A_SAMA500_1
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 1ycn PUTATIVE
CA2+-DEPENDENT
MEMBRANE-BINDING
PROTEIN ANNEXIN
(Arabidopsis
thaliana) 		4 / 6 THR A 142
ASP A 144
ASN A 185
ASP A 186
 None
 1.17A 2okcA-1ycnA:
undetectable		 2okcA-1ycnA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RHM_B_BEZB194_0
(PUTATIVE KINASE)		 1ycn PUTATIVE
CA2+-DEPENDENT
MEMBRANE-BINDING
PROTEIN ANNEXIN
(Arabidopsis
thaliana) 		4 / 5 PRO A 243
ILE A 280
ARG A 272
ASP A 276
 None
 1.34A 2rhmB-1ycnA:
undetectable		 2rhmB-1ycnA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_A_SAMA801_1
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 1ycn PUTATIVE
CA2+-DEPENDENT
MEMBRANE-BINDING
PROTEIN ANNEXIN
(Arabidopsis
thaliana) 		4 / 8 THR A 204
LEU A 193
ASP A 186
GLU A 215
 None
 1.06A 2zw9A-1ycnA:
undetectable		 2zw9A-1ycnA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK3_A_0LIA1_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 1ycn PUTATIVE
CA2+-DEPENDENT
MEMBRANE-BINDING
PROTEIN ANNEXIN
(Arabidopsis
thaliana) 		4 / 7 LEU A 118
VAL A 279
ILE A 275
MET A 107
 None
 1.04A 3ik3A-1ycnA:
undetectable		 3ik3A-1ycnA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK3_B_0LIB2_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 1ycn PUTATIVE
CA2+-DEPENDENT
MEMBRANE-BINDING
PROTEIN ANNEXIN
(Arabidopsis
thaliana) 		4 / 7 LEU A 118
VAL A 279
ILE A 275
MET A 107
 None
 1.08A 3ik3B-1ycnA:
undetectable		 3ik3B-1ycnA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_A_STIA2_2
(TYROSINE-PROTEIN
KINASE ABL1)		 1ycn PUTATIVE
CA2+-DEPENDENT
MEMBRANE-BINDING
PROTEIN ANNEXIN
(Arabidopsis
thaliana) 		4 / 6 LEU A 118
VAL A 279
ILE A 275
MET A 107
 None
 1.02A 3k5vA-1ycnA:
undetectable		 3k5vA-1ycnA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_B_STIB2_2
(TYROSINE-PROTEIN
KINASE ABL1)		 1ycn PUTATIVE
CA2+-DEPENDENT
MEMBRANE-BINDING
PROTEIN ANNEXIN
(Arabidopsis
thaliana) 		4 / 6 LEU A 118
VAL A 279
ILE A 275
MET A 107
 None
 1.13A 3k5vB-1ycnA:
undetectable		 3k5vB-1ycnA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N0H_A_TOPA187_1
(DIHYDROFOLATE
REDUCTASE)		 1ycn PUTATIVE
CA2+-DEPENDENT
MEMBRANE-BINDING
PROTEIN ANNEXIN
(Arabidopsis
thaliana) 		5 / 11 ILE A 179
THR A 204
ILE A 201
LEU A 193
VAL A 175
 None
 1.13A 3n0hA-1ycnA:
undetectable		 3n0hA-1ycnA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXC_A_ROCA401_2
(PROTEASE)		 1ycn PUTATIVE
CA2+-DEPENDENT
MEMBRANE-BINDING
PROTEIN ANNEXIN
(Arabidopsis
thaliana) 		3 / 3 ARG A 267
LEU A  91
THR A  96
 None
 0.89A 3oxcA-1ycnA:
undetectable		 3oxcA-1ycnA:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3V_A_TOPA187_1
(DIHYDROFOLATE
REDUCTASE)		 1ycn PUTATIVE
CA2+-DEPENDENT
MEMBRANE-BINDING
PROTEIN ANNEXIN
(Arabidopsis
thaliana) 		5 / 12 ILE A 179
THR A 204
ILE A 201
LEU A 193
VAL A 175
 None
 1.13A 3s3vA-1ycnA:
undetectable		 3s3vA-1ycnA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_B_ADNB401_1
(ADENOSINE KINASE,
PUTATIVE)		 1ycn PUTATIVE
CA2+-DEPENDENT
MEMBRANE-BINDING
PROTEIN ANNEXIN
(Arabidopsis
thaliana) 		5 / 12 ILE A 255
GLY A 263
ALA A 264
LEU A 308
GLY A 259
 None
 1.07A 3uq6B-1ycnA:
undetectable		 3uq6B-1ycnA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_STRA301_1
(ANCESTRAL STEROID
RECEPTOR 2)		 1ycn PUTATIVE
CA2+-DEPENDENT
MEMBRANE-BINDING
PROTEIN ANNEXIN
(Arabidopsis
thaliana) 		5 / 12 LEU A 233
LEU A 232
ALA A 231
GLN A 104
LEU A 217
 None
 1.19A 4ltwA-1ycnA:
undetectable		 4ltwA-1ycnA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZT_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 2)		 1ycn PUTATIVE
CA2+-DEPENDENT
MEMBRANE-BINDING
PROTEIN ANNEXIN
(Arabidopsis
thaliana) 		3 / 3 PHE A  24
THR A 270
LEU A  62
 None
 0.78A 4qztA-1ycnA:
undetectable		 4qztA-1ycnA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		 1ycn PUTATIVE
CA2+-DEPENDENT
MEMBRANE-BINDING
PROTEIN ANNEXIN
(Arabidopsis
thaliana) 		4 / 6 THR A 204
SER A 194
LEU A 193
LEU A 240
 None
 0.86A 4wozA-1ycnA:
undetectable
4wozB-1ycnA:
undetectable		 4wozA-1ycnA:
22.16
4wozB-1ycnA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESE_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1ycn PUTATIVE
CA2+-DEPENDENT
MEMBRANE-BINDING
PROTEIN ANNEXIN
(Arabidopsis
thaliana) 		4 / 8 LEU A 240
PHE A 205
ILE A 216
LEU A 148
 None
 0.89A 5eseA-1ycnA:
undetectable		 5eseA-1ycnA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_A_X2NA590_1
(CYP51 VARIANT1)		 1ycn PUTATIVE
CA2+-DEPENDENT
MEMBRANE-BINDING
PROTEIN ANNEXIN
(Arabidopsis
thaliana) 		5 / 12 ALA A 121
LEU A 240
PHE A 205
ILE A 216
LEU A 148
 None
 0.92A 5fsaA-1ycnA:
undetectable		 5fsaA-1ycnA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC608_1
(ALPHA-AMYLASE)		 1ycn PUTATIVE
CA2+-DEPENDENT
MEMBRANE-BINDING
PROTEIN ANNEXIN
(Arabidopsis
thaliana) 		3 / 3 TYR A 304
ALA A 310
LEU A 311
 None
 0.56A 6ag0C-1ycnA:
undetectable		 6ag0C-1ycnA:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EF6_A_ACTA405_0
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 1ycn PUTATIVE
CA2+-DEPENDENT
MEMBRANE-BINDING
PROTEIN ANNEXIN
(Arabidopsis
thaliana) 		4 / 6 THR A 271
ARG A 272
PRO A  84
GLN A 117
 None
 1.43A 6ef6A-1ycnA:
0.0		 6ef6A-1ycnA:
22.96