SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1yco'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_F_9CRF1600_1
(RETINOIC ACID
RECEPTOR, BETA)		 1yco BRANCHED-CHAIN
PHOSPHOTRANSACYLASE
(Enterococcus
faecalis) 		5 / 12 LEU A 266
LEU A  74
ILE A  72
LEU A  29
LEU A  17
 None
 1.02A 1xdkF-1ycoA:
undetectable		 1xdkF-1ycoA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CL9_A_MTXA602_2
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE (DHFR-TS))		 1yco BRANCHED-CHAIN
PHOSPHOTRANSACYLASE
(Enterococcus
faecalis) 		4 / 4 VAL A 251
ARG A 267
ILE A   2
THR A 253
 None
 1.36A 3cl9A-1ycoA:
undetectable		 3cl9A-1ycoA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q87_B_SAMB300_0
(N6 ADENINE SPECIFIC
DNA METHYLASE)		 1yco BRANCHED-CHAIN
PHOSPHOTRANSACYLASE
(Enterococcus
faecalis) 		5 / 12 THR A 253
GLY A   8
ASP A  35
ASN A  37
ASP A  53
 None
 1.22A 3q87B-1ycoA:
2.2		 3q87B-1ycoA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QG2_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1yco BRANCHED-CHAIN
PHOSPHOTRANSACYLASE
(Enterococcus
faecalis) 		5 / 10 ILE A 209
ALA A 194
SER A 167
TYR A 205
THR A 195
 None
 1.43A 3qg2A-1ycoA:
undetectable		 3qg2A-1ycoA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_C_9PLC501_1
(CYTOCHROME P450 2E1)		 1yco BRANCHED-CHAIN
PHOSPHOTRANSACYLASE
(Enterococcus
faecalis) 		4 / 5 PHE A 177
ALA A 137
THR A 117
LEU A 153
 None
 1.22A 3t3zC-1ycoA:
undetectable		 3t3zC-1ycoA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOP_A_HQEA503_1
(CATALASE)		 1yco BRANCHED-CHAIN
PHOSPHOTRANSACYLASE
(Enterococcus
faecalis) 		5 / 9 ILE A   2
PHE A  31
LEU A  29
LEU A 266
PHE A 263
 None
 1.43A 4qopA-1ycoA:
undetectable		 4qopA-1ycoA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOP_B_HQEB503_1
(CATALASE)		 1yco BRANCHED-CHAIN
PHOSPHOTRANSACYLASE
(Enterococcus
faecalis) 		5 / 9 ILE A   2
PHE A  31
LEU A  29
LEU A 266
PHE A 263
 None
 1.44A 4qopB-1ycoA:
undetectable		 4qopB-1ycoA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1yco BRANCHED-CHAIN
PHOSPHOTRANSACYLASE
(Enterococcus
faecalis) 		5 / 11 THR A 253
THR A  80
THR A  82
GLY A  76
ALA A   7
 None
 1.50A 4qvpH-1ycoA:
undetectable
4qvpN-1ycoA:
undetectable		 4qvpH-1ycoA:
23.55
4qvpN-1ycoA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1yco BRANCHED-CHAIN
PHOSPHOTRANSACYLASE
(Enterococcus
faecalis) 		5 / 11 THR A 253
THR A  80
THR A  82
GLY A  76
ALA A   7
 None
 1.46A 4qvwV-1ycoA:
undetectable
4qvwb-1ycoA:
undetectable		 4qvwV-1ycoA:
23.55
4qvwb-1ycoA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1yco BRANCHED-CHAIN
PHOSPHOTRANSACYLASE
(Enterococcus
faecalis) 		5 / 11 THR A 253
THR A  80
THR A  82
GLY A  76
ALA A   7
 None
 1.46A 4qvwH-1ycoA:
undetectable
4qvwN-1ycoA:
undetectable		 4qvwH-1ycoA:
23.55
4qvwN-1ycoA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1yco BRANCHED-CHAIN
PHOSPHOTRANSACYLASE
(Enterococcus
faecalis) 		5 / 11 THR A 253
THR A  80
THR A  82
GLY A  76
ALA A   7
 None
 1.46A 4qw1V-1ycoA:
undetectable
4qw1b-1ycoA:
undetectable		 4qw1V-1ycoA:
23.55
4qw1b-1ycoA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1yco BRANCHED-CHAIN
PHOSPHOTRANSACYLASE
(Enterococcus
faecalis) 		5 / 11 THR A 253
THR A  80
THR A  82
GLY A  76
ALA A   7
 None
 1.45A 4qw1H-1ycoA:
undetectable
4qw1N-1ycoA:
undetectable		 4qw1H-1ycoA:
23.55
4qw1N-1ycoA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1yco BRANCHED-CHAIN
PHOSPHOTRANSACYLASE
(Enterococcus
faecalis) 		5 / 11 THR A 253
THR A  80
THR A  82
GLY A  76
ALA A   7
 None
 1.45A 4qwuV-1ycoA:
undetectable
4qwub-1ycoA:
undetectable		 4qwuV-1ycoA:
23.55
4qwub-1ycoA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1yco BRANCHED-CHAIN
PHOSPHOTRANSACYLASE
(Enterococcus
faecalis) 		5 / 11 THR A 253
THR A  80
THR A  82
GLY A  76
ALA A   7
 None
 1.44A 4qwuH-1ycoA:
undetectable
4qwuN-1ycoA:
undetectable		 4qwuH-1ycoA:
23.55
4qwuN-1ycoA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1yco BRANCHED-CHAIN
PHOSPHOTRANSACYLASE
(Enterococcus
faecalis) 		5 / 11 THR A 253
THR A  80
THR A  82
GLY A  76
ALA A   7
 None
 1.48A 5bxnV-1ycoA:
undetectable
5bxnb-1ycoA:
undetectable		 5bxnV-1ycoA:
21.84
5bxnb-1ycoA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1yco BRANCHED-CHAIN
PHOSPHOTRANSACYLASE
(Enterococcus
faecalis) 		5 / 11 THR A 253
THR A  80
THR A  82
GLY A  76
ALA A   7
 None
 1.48A 5bxnH-1ycoA:
undetectable
5bxnN-1ycoA:
undetectable		 5bxnH-1ycoA:
21.84
5bxnN-1ycoA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CZ7_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1yco BRANCHED-CHAIN
PHOSPHOTRANSACYLASE
(Enterococcus
faecalis) 		5 / 11 THR A 253
THR A  80
THR A  82
GLY A  76
ALA A   7
 None
 1.47A 5cz7H-1ycoA:
undetectable
5cz7N-1ycoA:
undetectable		 5cz7H-1ycoA:
23.55
5cz7N-1ycoA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0Y_A_FOLA201_1
(CONSERVED
HYPOTHETICAL
MEMBRANE PROTEIN)		 1yco BRANCHED-CHAIN
PHOSPHOTRANSACYLASE
(Enterococcus
faecalis) 		3 / 3 ARG A 267
LYS A  20
GLU A  24
 None
 0.78A 5d0yA-1ycoA:
undetectable		 5d0yA-1ycoA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UIH_A_8CVA201_1
(DIHYDROFOLATE
REDUCTASE)		 1yco BRANCHED-CHAIN
PHOSPHOTRANSACYLASE
(Enterococcus
faecalis) 		4 / 8 ALA A 194
LEU A 116
ILE A 151
THR A 195
 None
 0.89A 5uihA-1ycoA:
undetectable		 5uihA-1ycoA:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AZ3_1_PAR11803_1
(RRNA ALPHA
RIBOSOMAL PROTEIN
EL18)		 1yco BRANCHED-CHAIN
PHOSPHOTRANSACYLASE
(Enterococcus
faecalis) 		3 / 3 SER A 261
LYS A 262
SER A 265
 None
 0.72A 6az3P-1ycoA:
undetectable		 6az3P-1ycoA:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7U_A_FVTA501_0
(PEPTIDE ABC
TRANSPORTER PERMEASE)		 1yco BRANCHED-CHAIN
PHOSPHOTRANSACYLASE
(Enterococcus
faecalis) 		4 / 6 VAL A 218
ASN A 122
PRO A 125
ILE A 133
 None
 1.24A 6h7uA-1ycoA:
undetectable		 6h7uA-1ycoA:
18.16