SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1yd8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V3K_A_SAMA1254_0
(ESSENTIAL FOR
MITOTIC GROWTH 1)		 1yd8 ADP-RIBOSYLATION
FACTOR BINDING
PROTEIN GGA3
(Homo
sapiens) 		5 / 10 LEU G 280
GLY G 277
LEU G 276
SER G 275
ALA G 266
 None
 0.99A 2v3kA-1yd8G:
undetectable		 2v3kA-1yd8G:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFG_B_LEUB289_0
(GLYCYL-TRNA
SYNTHETASE ALPHA
SUBUNIT)		 1yd8 ADP-RIBOSYLATION
FACTOR BINDING
PROTEIN GGA3
(Homo
sapiens) 		3 / 3 PHE G 263
SER G 287
SER G 283
 None
 0.85A 3ufgB-1yd8G:
undetectable		 3ufgB-1yd8G:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WQ4_B_ACTB403_0
(TRNA N6-ADENOSINE
THREONYLCARBAMOYLTRA
NSFERASE)		 1yd8 ADP-RIBOSYLATION
FACTOR BINDING
PROTEIN GGA3
(Homo
sapiens) 		3 / 3 ARG G 259
ASP G 284
ARG G 288
 None
 0.36A 4wq4B-1yd8G:
undetectable		 4wq4B-1yd8G:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBR_A_NPSA603_1
(SERUM ALBUMIN)		 1yd8 ADP-RIBOSYLATION
FACTOR BINDING
PROTEIN GGA3
(Homo
sapiens) 		5 / 10 LEU G 276
LEU G 262
ALA G 266
SER G 287
LEU G 286
 None
 1.16A 4zbrA-1yd8G:
undetectable		 4zbrA-1yd8G:
11.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FCT_B_C2FB402_1
(THYMIDYLATE SYNTHASE)		 1yd8 ADP-RIBOSYLATION
FACTOR BINDING
PROTEIN GGA3
(Homo
sapiens) 		3 / 3 ASN G 285
ASP G 278
GLY G 277
 None
 0.66A 5fctB-1yd8G:
undetectable		 5fctB-1yd8G:
16.83