SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ydf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ6_B_CAMB502_0
(CYTOCHROME P450-CAM)		 1ydf HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY
(Streptococcus
pneumoniae) 		4 / 5 TYR A  16
VAL A  53
VAL A  42
ASP A  10
 None
None
None
MG  A 500 (-2.8A)
 1.35A 1dz6B-1ydfA:
undetectable		 1dz6B-1ydfA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_G_TRPG81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1ydf HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY
(Streptococcus
pneumoniae) 		4 / 7 GLY A 216
THR A 244
THR A 223
ILE A 217
 None
 0.96A 1gtnF-1ydfA:
undetectable
1gtnG-1ydfA:
undetectable		 1gtnF-1ydfA:
14.17
1gtnG-1ydfA:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_K_TRPK81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1ydf HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY
(Streptococcus
pneumoniae) 		4 / 7 GLY A 216
THR A 244
THR A 223
ILE A 217
 None
 0.97A 1gtnJ-1ydfA:
undetectable
1gtnK-1ydfA:
undetectable		 1gtnJ-1ydfA:
14.17
1gtnK-1ydfA:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HPK_A_ACAA80_1
(PLASMINOGEN)		 1ydf HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY
(Streptococcus
pneumoniae) 		4 / 6 ASP A 207
ASN A 208
ASP A  10
TYR A  16
 MG  A 500 (-2.8A)
None
MG  A 500 (-2.8A)
None
 1.14A 1hpkA-1ydfA:
undetectable		 1hpkA-1ydfA:
12.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UYU_A_CAMA1416_0
(CYTOCHROME P450-CAM)		 1ydf HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY
(Streptococcus
pneumoniae) 		4 / 8 TYR A  16
VAL A  53
THR A  72
ASP A  10
 None
None
None
MG  A 500 (-2.8A)
 1.10A 1uyuA-1ydfA:
undetectable		 1uyuA-1ydfA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UYU_B_CAMB1416_0
(CYTOCHROME P450-CAM)		 1ydf HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY
(Streptococcus
pneumoniae) 		4 / 8 TYR A  16
VAL A  53
THR A  72
ASP A  10
 None
None
None
MG  A 500 (-2.8A)
 1.09A 1uyuB-1ydfA:
undetectable		 1uyuB-1ydfA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOJ_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 1ydf HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY
(Streptococcus
pneumoniae) 		5 / 7 LEU A 224
GLY A 220
ILE A 217
VAL A 205
ILE A 203
 None
 1.35A 2aojB-1ydfA:
undetectable		 2aojB-1ydfA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZAX_A_CAMA422_0
(CYTOCHROME P450-CAM)		 1ydf HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY
(Streptococcus
pneumoniae) 		4 / 7 TYR A  16
VAL A  53
THR A  72
ASP A  10
 None
None
None
MG  A 500 (-2.8A)
 1.07A 2zaxA-1ydfA:
undetectable		 2zaxA-1ydfA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FWG_B_CAMB420_0
(CAMPHOR
5-MONOOXYGENASE)		 1ydf HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY
(Streptococcus
pneumoniae) 		4 / 7 TYR A  16
VAL A  53
THR A  72
ASP A  10
 None
None
None
MG  A 500 (-2.8A)
 1.09A 3fwgB-1ydfA:
undetectable		 3fwgB-1ydfA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q87_B_SAMB300_0
(N6 ADENINE SPECIFIC
DNA METHYLASE)		 1ydf HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY
(Streptococcus
pneumoniae) 		5 / 12 THR A 146
GLY A 161
ILE A 166
LEU A 158
ASN A 147
 None
 1.03A 3q87B-1ydfA:
undetectable		 3q87B-1ydfA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q87_B_SAMB300_0
(N6 ADENINE SPECIFIC
DNA METHYLASE)		 1ydf HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY
(Streptococcus
pneumoniae) 		5 / 12 THR A 146
GLY A 161
ILE A 166
LEU A 159
ASN A 147
 None
 1.11A 3q87B-1ydfA:
undetectable		 3q87B-1ydfA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOG_A_ML1A302_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1ydf HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY
(Streptococcus
pneumoniae) 		4 / 8 ILE A 203
PHE A  28
GLY A 206
ILE A 213
 None
 0.77A 4qogA-1ydfA:
3.3
4qogB-1ydfA:
3.3		 4qogA-1ydfA:
24.64
4qogB-1ydfA:
24.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YJI_A_TYLA502_1
(ARYL ACYLAMIDASE)		 1ydf HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY
(Streptococcus
pneumoniae) 		5 / 7 LEU A  98
THR A  46
GLY A 181
ALA A  73
ILE A 186
 None
 1.19A 4yjiA-1ydfA:
undetectable		 4yjiA-1ydfA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCE_A_RITA602_1
(CYTOCHROME P450 3A4)		 1ydf HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY
(Streptococcus
pneumoniae) 		5 / 12 ALA A 172
THR A 173
ILE A 137
ALA A 136
GLU A 112
 None
 1.10A 5vceA-1ydfA:
0.0		 5vceA-1ydfA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA504_1
(CYTOCHROME P450 2C9)		 1ydf HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY
(Streptococcus
pneumoniae) 		4 / 8 PHE A  28
ILE A  15
PRO A  66
THR A  65
 None
 1.15A 5x23A-1ydfA:
undetectable		 5x23A-1ydfA:
18.74