SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ydn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FFY_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 1ydn HYDROXYMETHYLGLUTARY
L-COA LYASE
(Brucella
melitensis) 		5 / 12 PRO A 239
GLY A 234
GLY A  15
ASP A  14
VAL A 232
 None
None
None
CA  A 601 (-2.7A)
None
 1.25A 1ffyA-1ydnA:
undetectable		 1ffyA-1ydnA:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GM7_B_PNNB1577_0
(PENICILLIN G ACYLASE
ALPHA SUBUNIT
PENICILLIN G ACYLASE
BETA SUBUNIT)		 1ydn HYDROXYMETHYLGLUTARY
L-COA LYASE
(Brucella
melitensis) 		4 / 8 SER A 141
SER A 107
ALA A 102
ILE A 115
 None
 1.11A 1gm7A-1ydnA:
undetectable
1gm7B-1ydnA:
undetectable		 1gm7A-1ydnA:
21.58
1gm7B-1ydnA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PNL_B_PACB559_0
(PENICILLIN
AMIDOHYDROLASE)		 1ydn HYDROXYMETHYLGLUTARY
L-COA LYASE
(Brucella
melitensis) 		4 / 8 SER A 141
SER A 107
ALA A 102
ILE A 115
 None
 1.09A 1pnlA-1ydnA:
undetectable
1pnlB-1ydnA:
undetectable		 1pnlA-1ydnA:
21.58
1pnlB-1ydnA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XH9_A_J01A1437_1
(ORF12)		 1ydn HYDROXYMETHYLGLUTARY
L-COA LYASE
(Brucella
melitensis) 		5 / 11 THR A  46
SER A  60
ALA A  91
ALA A  88
ARG A  69
 None
 1.39A 2xh9A-1ydnA:
undetectable		 2xh9A-1ydnA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9T_A_BEZA264_0
(ECHA1_1)		 1ydn HYDROXYMETHYLGLUTARY
L-COA LYASE
(Brucella
melitensis) 		4 / 8 ALA A 129
ILE A 136
ALA A  88
ALA A  89
 None
 0.68A 3r9tA-1ydnA:
2.4		 3r9tA-1ydnA:
25.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SJ1_X_DXCX75_0
(CYTOCHROME C7)		 1ydn HYDROXYMETHYLGLUTARY
L-COA LYASE
(Brucella
melitensis) 		4 / 6 ILE A 217
LEU A 221
PHE A 262
GLY A 261
 None
 1.04A 3sj1X-1ydnA:
undetectable		 3sj1X-1ydnA:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ECK_A_FOLA703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1ydn HYDROXYMETHYLGLUTARY
L-COA LYASE
(Brucella
melitensis) 		5 / 12 VAL A 125
LEU A  78
SER A 118
LEU A 164
VAL A 160
 None
 1.02A 4eckA-1ydnA:
undetectable		 4eckA-1ydnA:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HBF_A_DXCA75_0
(PPCA)		 1ydn HYDROXYMETHYLGLUTARY
L-COA LYASE
(Brucella
melitensis) 		4 / 7 ILE A 217
LEU A 221
PHE A 262
GLY A 261
 None
 1.07A 4hbfA-1ydnA:
undetectable		 4hbfA-1ydnA:
13.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CP4_A_CAMA422_0
(CYTOCHROME P450CAM)		 1ydn HYDROXYMETHYLGLUTARY
L-COA LYASE
(Brucella
melitensis) 		4 / 8 TYR A 206
LEU A 190
THR A 161
VAL A 140
 None
 0.87A 6cp4A-1ydnA:
undetectable		 6cp4A-1ydnA:
22.57