SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ydo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_D_ESTD352_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 1ydo HMG-COA LYASE
(Bacillus
subtilis) 		4 / 6 SER A 233
GLY A 236
LEU A 288
GLU A 282
 None
 1.01A 1fduD-1ydoA:
2.3		 1fduD-1ydoA:
25.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		 1ydo HMG-COA LYASE
(Bacillus
subtilis) 		5 / 8 CYH A  99
ASN A 128
LEU A  87
ALA A  90
LEU A  91
 None
 0.85A 1hwiB-1ydoA:
undetectable		 1hwiB-1ydoA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_1
(HMG-COA REDUCTASE)		 1ydo HMG-COA LYASE
(Bacillus
subtilis) 		5 / 9 CYH A  99
ASN A 128
LEU A  87
ALA A  90
LEU A  91
 None
 0.84A 1hwiA-1ydoA:
0.0		 1hwiA-1ydoA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		 1ydo HMG-COA LYASE
(Bacillus
subtilis) 		5 / 8 CYH A  99
ASN A 128
LEU A  87
ALA A  90
LEU A  91
 None
 0.84A 1hwiD-1ydoA:
undetectable		 1hwiD-1ydoA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		 1ydo HMG-COA LYASE
(Bacillus
subtilis) 		5 / 8 CYH A  99
ASN A 128
LEU A  87
ALA A  90
LEU A  91
 None
 0.84A 1hwiC-1ydoA:
undetectable		 1hwiC-1ydoA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_A_117A2_2
(HMG-COA REDUCTASE)		 1ydo HMG-COA LYASE
(Bacillus
subtilis) 		5 / 11 CYH A  99
ASN A 128
LEU A  87
ALA A  90
LEU A  91
 None
 0.90A 1hwkB-1ydoA:
0.0		 1hwkB-1ydoA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_B_117B1_1
(HMG-COA REDUCTASE)		 1ydo HMG-COA LYASE
(Bacillus
subtilis) 		5 / 11 CYH A  99
ASN A 128
LEU A  87
ALA A  90
LEU A  91
 None
 0.91A 1hwkA-1ydoA:
0.0		 1hwkA-1ydoA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_C_117C4_2
(HMG-COA REDUCTASE)		 1ydo HMG-COA LYASE
(Bacillus
subtilis) 		5 / 11 CYH A  99
ASN A 128
LEU A  87
ALA A  90
LEU A  91
 None
 0.88A 1hwkD-1ydoA:
0.0		 1hwkD-1ydoA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_D_117D3_1
(HMG-COA REDUCTASE)		 1ydo HMG-COA LYASE
(Bacillus
subtilis) 		5 / 11 CYH A  99
ASN A 128
LEU A  87
ALA A  90
LEU A  91
 None
 0.88A 1hwkC-1ydoA:
0.0		 1hwkC-1ydoA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J3J_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1ydo HMG-COA LYASE
(Bacillus
subtilis) 		5 / 10 ILE A  31
ASP A  61
ILE A  95
ILE A  69
THR A  27
 None
 1.30A 1j3jA-1ydoA:
undetectable		 1j3jA-1ydoA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WYG_A_SALA4005_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 1ydo HMG-COA LYASE
(Bacillus
subtilis) 		5 / 10 GLU A  11
LEU A  42
ALA A 234
ALA A 277
GLU A 253
 None
 1.47A 1wygA-1ydoA:
0.0		 1wygA-1ydoA:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DCF_A_ACAA502_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 1ydo HMG-COA LYASE
(Bacillus
subtilis) 		5 / 12 ALA A 183
VAL A 154
ASP A 153
GLY A 181
ILE A 180
 None
 1.15A 2dcfA-1ydoA:
undetectable		 2dcfA-1ydoA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKK_A_2FAA501_1
(ADENOSINE KINASE)		 1ydo HMG-COA LYASE
(Bacillus
subtilis) 		5 / 12 GLY A 236
GLY A 235
ALA A 276
GLN A  36
GLY A 232
 None
 1.03A 2pkkA-1ydoA:
2.3		 2pkkA-1ydoA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_B_SVRB512_1
(PHOSPHOLIPASE A2)		 1ydo HMG-COA LYASE
(Bacillus
subtilis) 		4 / 5 VAL A  12
THR A  40
THR A  48
ARG A  15
 None
 1.05A 3bjwA-1ydoA:
undetectable		 3bjwA-1ydoA:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF509_1
(PHOSPHOLIPASE A2)		 1ydo HMG-COA LYASE
(Bacillus
subtilis) 		4 / 5 VAL A  12
THR A  40
THR A  48
ARG A  15
 None
 0.99A 3bjwC-1ydoA:
undetectable		 3bjwC-1ydoA:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QGT_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1ydo HMG-COA LYASE
(Bacillus
subtilis) 		5 / 10 ILE A  31
ASP A  61
ILE A  95
ILE A  69
THR A  27
 None
 1.30A 3qgtA-1ydoA:
undetectable		 3qgtA-1ydoA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UM5_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1ydo HMG-COA LYASE
(Bacillus
subtilis) 		5 / 10 ILE A  31
ASP A  61
ILE A  95
ILE A  69
THR A  27
 None
 1.37A 3um5A-1ydoA:
undetectable		 3um5A-1ydoA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UM5_B_CP6B709_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1ydo HMG-COA LYASE
(Bacillus
subtilis) 		5 / 10 ILE A  31
ASP A  61
ILE A  95
ILE A  69
THR A  27
 None
 1.33A 3um5B-1ydoA:
undetectable		 3um5B-1ydoA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V1N_A_BEZA288_0
(2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE)		 1ydo HMG-COA LYASE
(Bacillus
subtilis) 		5 / 8 GLY A 236
GLY A 235
GLY A 232
LEU A  42
VAL A  12
 None
 1.12A 3v1nA-1ydoA:
undetectable		 3v1nA-1ydoA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V1N_A_BEZA288_0
(2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE)		 1ydo HMG-COA LYASE
(Bacillus
subtilis) 		5 / 8 GLY A 236
GLY A 235
SER A 233
GLY A 232
VAL A  12
 None
 1.30A 3v1nA-1ydoA:
undetectable		 3v1nA-1ydoA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HB6_A_DXCA75_0
(PPCA)		 1ydo HMG-COA LYASE
(Bacillus
subtilis) 		5 / 8 ILE A 264
LEU A 223
LYS A  10
ILE A   9
PHE A 230
 None
 1.37A 4hb6A-1ydoA:
undetectable		 4hb6A-1ydoA:
11.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HB8_A_DXCA75_0
(PPCA)		 1ydo HMG-COA LYASE
(Bacillus
subtilis) 		5 / 8 ILE A 264
LEU A 223
LYS A  10
ILE A   9
PHE A 230
 None
 1.31A 4hb8A-1ydoA:
undetectable		 4hb8A-1ydoA:
11.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NX6_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 1ydo HMG-COA LYASE
(Bacillus
subtilis) 		4 / 4 ILE A  31
ASP A  61
ARG A  71
THR A  27
 None
 1.24A 4nx6A-1ydoA:
undetectable		 4nx6A-1ydoA:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NX7_A_FOLA202_1
(DIHYDROFOLATE
REDUCTASE)		 1ydo HMG-COA LYASE
(Bacillus
subtilis) 		4 / 4 ILE A  31
ASP A  61
ARG A  71
THR A  27
 None
 1.24A 4nx7A-1ydoA:
undetectable		 4nx7A-1ydoA:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P68_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 1ydo HMG-COA LYASE
(Bacillus
subtilis) 		5 / 11 ILE A  31
ASP A  61
ILE A  95
ILE A  69
THR A  27
 None
 1.40A 4p68A-1ydoA:
undetectable		 4p68A-1ydoA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWJ_A_30ZA201_1
(TRANSTHYRETIN)		 1ydo HMG-COA LYASE
(Bacillus
subtilis) 		4 / 6 THR A  76
ALA A  78
LEU A  80
SER A  49
 None
 1.02A 4pwjA-1ydoA:
undetectable		 4pwjA-1ydoA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RFQ_A_SAMA401_1
(HISTIDINE PROTEIN
METHYLTRANSFERASE 1
HOMOLOG)		 1ydo HMG-COA LYASE
(Bacillus
subtilis) 		4 / 4 THR A 211
GLY A 238
ASP A  16
SER A 247
 None
 1.29A 4rfqA-1ydoA:
undetectable		 4rfqA-1ydoA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_B_NOVB2000_1
(DNA GYRASE SUBUNIT B)		 1ydo HMG-COA LYASE
(Bacillus
subtilis) 		5 / 12 GLU A  46
ILE A  47
ASP A  61
ILE A  34
SER A  38
 None
 1.08A 4uroB-1ydoA:
undetectable		 4uroB-1ydoA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_C_NOVC2000_1
(DNA GYRASE SUBUNIT B)		 1ydo HMG-COA LYASE
(Bacillus
subtilis) 		5 / 12 GLU A  46
ILE A  47
ASP A  61
ILE A  34
SER A  38
 None
 1.07A 4uroC-1ydoA:
undetectable		 4uroC-1ydoA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V1F_B_BQ1B1087_0
(F0F1 ATP SYNTHASE
SUBUNIT C)		 1ydo HMG-COA LYASE
(Bacillus
subtilis) 		5 / 8 ALA A 276
ALA A 277
ILE A 280
ALA A 250
LEU A 237
 None
 1.16A 4v1fA-1ydoA:
undetectable
4v1fB-1ydoA:
undetectable		 4v1fA-1ydoA:
15.89
4v1fB-1ydoA:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_C_CVIC301_0
(REGULATORY PROTEIN
TETR)		 1ydo HMG-COA LYASE
(Bacillus
subtilis) 		5 / 12 ALA A  62
GLU A  88
TYR A  44
VAL A  81
CYH A  99
 None
 1.28A 5vlmC-1ydoA:
0.3		 5vlmC-1ydoA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC607_0
(ALPHA-AMYLASE)		 1ydo HMG-COA LYASE
(Bacillus
subtilis) 		4 / 6 GLY A 235
GLY A  13
PRO A  14
GLY A  17
 None
 0.69A 6ag0C-1ydoA:
5.6		 6ag0C-1ydoA:
13.42