SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ydx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KCE_A_D16A566_2
(THYMIDYLATE SYNTHASE)		 1ydx TYPE I RESTRICTION
ENZYME SPECIFICITY
PROTEIN MG438
(Mycoplasma
genitalium) 		3 / 3 HIS A 191
ILE A 340
LEU A 173
 None
 0.73A 2kceA-1ydxA:
undetectable		 2kceA-1ydxA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4N_A_TPVA300_2
(PROTEASE)		 1ydx TYPE I RESTRICTION
ENZYME SPECIFICITY
PROTEIN MG438
(Mycoplasma
genitalium) 		4 / 8 LEU A 317
ILE A 323
GLY A 262
ILE A 255
 None
 0.76A 2o4nB-1ydxA:
undetectable		 2o4nB-1ydxA:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_A_SAMA220_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 1ydx TYPE I RESTRICTION
ENZYME SPECIFICITY
PROTEIN MG438
(Mycoplasma
genitalium) 		4 / 8 LYS A 318
ASP A 310
MET A 307
GLU A 322
 None
 1.41A 3dh0A-1ydxA:
undetectable		 3dh0A-1ydxA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F33_A_PFLA2001_1
(FERRITIN LIGHT CHAIN)		 1ydx TYPE I RESTRICTION
ENZYME SPECIFICITY
PROTEIN MG438
(Mycoplasma
genitalium) 		4 / 6 LEU A 355
TYR A 351
LEU A 348
LEU A 163
 None
 1.02A 3f33A-1ydxA:
1.5		 3f33A-1ydxA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R24_A_SAMA302_1
(2'-O-METHYL
TRANSFERASE)		 1ydx TYPE I RESTRICTION
ENZYME SPECIFICITY
PROTEIN MG438
(Mycoplasma
genitalium) 		3 / 3 TYR A 106
ASP A  79
ASP A 157
 None
 0.68A 3r24A-1ydxA:
undetectable		 3r24A-1ydxA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_D_SAMD601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 1ydx TYPE I RESTRICTION
ENZYME SPECIFICITY
PROTEIN MG438
(Mycoplasma
genitalium) 		5 / 12 ALA A 234
GLY A 235
ASN A 273
GLY A 274
ASN A 257
 None
 1.26A 4obwD-1ydxA:
undetectable		 4obwD-1ydxA:
25.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XTA_B_DIFB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1ydx TYPE I RESTRICTION
ENZYME SPECIFICITY
PROTEIN MG438
(Mycoplasma
genitalium) 		4 / 8 ILE A 129
LEU A  94
LEU A  21
ILE A  18
 None
 0.95A 4xtaB-1ydxA:
undetectable		 4xtaB-1ydxA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR1_B_017B101_1
(PROTEASE PR5-DRV)		 1ydx TYPE I RESTRICTION
ENZYME SPECIFICITY
PROTEIN MG438
(Mycoplasma
genitalium) 		5 / 10 ASN A 284
ILE A 204
GLY A 207
VAL A 289
ILE A 287
 None
 1.03A 5kr1A-1ydxA:
undetectable		 5kr1A-1ydxA:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR2_C_ROCC101_2
(PROTEASE PR5-SQV)		 1ydx TYPE I RESTRICTION
ENZYME SPECIFICITY
PROTEIN MG438
(Mycoplasma
genitalium) 		5 / 9 ASN A 284
ILE A 204
GLY A 207
VAL A 289
ILE A 287
 None
 1.16A 5kr2D-1ydxA:
undetectable		 5kr2D-1ydxA:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G1P_A_ACTA403_0
(ADP-RIBOSYLHYDROLASE
LIKE 2)		 1ydx TYPE I RESTRICTION
ENZYME SPECIFICITY
PROTEIN MG438
(Mycoplasma
genitalium) 		3 / 3 TYR A 351
ASP A 349
GLN A 350
 None
 0.96A 6g1pA-1ydxA:
undetectable		 6g1pA-1ydxA:
21.99