SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ye8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_D_BRLD503_2
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 1ye8 HYPOTHETICAL UPF0334
KINASE-LIKE PROTEIN
AQ_1292
(Aquifex
aeolicus) 		4 / 4 ILE A   4
LEU A 113
VAL A 122
ILE A 105
 None
 0.88A 1fm6D-1ye8A:
undetectable		 1fm6D-1ye8A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KI7_B_ID2B2_0
(THYMIDINE KINASE)		 1ye8 HYPOTHETICAL UPF0334
KINASE-LIKE PROTEIN
AQ_1292
(Aquifex
aeolicus) 		5 / 12 GLU A 148
ILE A 108
ILE A 105
MET A 126
ARG A 123
 None
 1.38A 1ki7B-1ye8A:
2.4		 1ki7B-1ye8A:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_A_HSMA303_1
(NITROPHORIN 1)		 1ye8 HYPOTHETICAL UPF0334
KINASE-LIKE PROTEIN
AQ_1292
(Aquifex
aeolicus) 		4 / 5 GLU A 170
LEU A 176
LEU A 173
LEU A 175
 None
 1.13A 1np1A-1ye8A:
undetectable		 1np1A-1ye8A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BYO_A_LNLA1217_1
(LIPOPROTEIN LPPX)		 1ye8 HYPOTHETICAL UPF0334
KINASE-LIKE PROTEIN
AQ_1292
(Aquifex
aeolicus) 		4 / 4 VAL A 102
LEU A 160
ILE A 168
LEU A 169
 None
 1.04A 2byoA-1ye8A:
undetectable		 2byoA-1ye8A:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		 1ye8 HYPOTHETICAL UPF0334
KINASE-LIKE PROTEIN
AQ_1292
(Aquifex
aeolicus) 		5 / 12 LEU A  88
ALA A  91
ILE A  29
THR A  52
ILE A   3
 None
 1.14A 2jn3A-1ye8A:
undetectable		 2jn3A-1ye8A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_B_P1BB1475_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1ye8 HYPOTHETICAL UPF0334
KINASE-LIKE PROTEIN
AQ_1292
(Aquifex
aeolicus) 		4 / 6 LEU A 173
ARG A  23
ILE A  20
ILE A  87
 None
 0.93A 2xkwB-1ye8A:
undetectable		 2xkwB-1ye8A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMH_A_SAMA384_1
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 1ye8 HYPOTHETICAL UPF0334
KINASE-LIKE PROTEIN
AQ_1292
(Aquifex
aeolicus) 		3 / 3 SER A  66
GLU A  81
ASP A 120
 None
 0.77A 3dmhA-1ye8A:
undetectable		 3dmhA-1ye8A:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_A_EPAA1_2
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 1ye8 HYPOTHETICAL UPF0334
KINASE-LIKE PROTEIN
AQ_1292
(Aquifex
aeolicus) 		5 / 12 THR A  52
LEU A  24
ILE A   3
MET A 126
LEU A  88
 None
 1.34A 3gwxA-1ye8A:
0.0		 3gwxA-1ye8A:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_B_ACTB4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 1ye8 HYPOTHETICAL UPF0334
KINASE-LIKE PROTEIN
AQ_1292
(Aquifex
aeolicus) 		3 / 3 GLY A  10
GLY A  12
THR A  14
 PO4  A1001 ( 3.3A)
PO4  A1001 (-3.0A)
MG  A1002 ( 3.2A)
 0.44A 3si7B-1ye8A:
5.7		 3si7B-1ye8A:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		 1ye8 HYPOTHETICAL UPF0334
KINASE-LIKE PROTEIN
AQ_1292
(Aquifex
aeolicus) 		4 / 8 ILE A  49
PHE A  59
LEU A  88
VAL A 122
 None
 0.84A 3ua5A-1ye8A:
undetectable		 3ua5A-1ye8A:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESE_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1ye8 HYPOTHETICAL UPF0334
KINASE-LIKE PROTEIN
AQ_1292
(Aquifex
aeolicus) 		5 / 8 LEU A  88
PHE A  80
ILE A  49
PHE A 118
THR A 136
 None
 1.40A 5eseA-1ye8A:
undetectable		 5eseA-1ye8A:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EMU_A_SAMA501_0
(TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE)		 1ye8 HYPOTHETICAL UPF0334
KINASE-LIKE PROTEIN
AQ_1292
(Aquifex
aeolicus) 		5 / 12 LEU A 169
THR A 161
ILE A  20
VAL A 134
ILE A 172
 None
 0.86A 6emuA-1ye8A:
undetectable		 6emuA-1ye8A:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EMU_B_SAMB301_0
(TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE)		 1ye8 HYPOTHETICAL UPF0334
KINASE-LIKE PROTEIN
AQ_1292
(Aquifex
aeolicus) 		5 / 12 LEU A 169
THR A 161
ILE A  20
VAL A 134
ILE A 172
 None
 0.84A 6emuB-1ye8A:
undetectable		 6emuB-1ye8A:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EMU_C_SAMC301_0
(TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE)		 1ye8 HYPOTHETICAL UPF0334
KINASE-LIKE PROTEIN
AQ_1292
(Aquifex
aeolicus) 		5 / 12 LEU A 169
THR A 161
ILE A  20
VAL A 134
ILE A 172
 None
 0.84A 6emuC-1ye8A:
2.2		 6emuC-1ye8A:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_C_ADNC502_1
(ADENOSYLHOMOCYSTEINA
SE)		 1ye8 HYPOTHETICAL UPF0334
KINASE-LIKE PROTEIN
AQ_1292
(Aquifex
aeolicus) 		3 / 3 LEU A 145
GLY A 109
PHE A  31
 None
 0.65A 6exiC-1ye8A:
undetectable		 6exiC-1ye8A:
21.30