SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ye9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U65_A_CP0A1000_1
(ACETYLCHOLINESTERASE)		 1ye9 CATALASE HPII
(Escherichia
coli) 		5 / 11 GLN A 246
LEU E 547
ASP E 545
TYR A 242
HIS A 236
 None
 1.45A 1u65A-1ye9A:
undetectable		 1u65A-1ye9A:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_B_PNXB2434_1
(CHITINASE)		 1ye9 CATALASE HPII
(Escherichia
coli) 		4 / 6 TRP E 512
GLY E 526
PHE E 527
SER E 528
 None
 1.35A 2a3cB-1ye9E:
undetectable		 2a3cB-1ye9E:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_4
(POL POLYPROTEIN)		 1ye9 CATALASE HPII
(Escherichia
coli) 		3 / 3 ARG E 411
VAL A 289
GLY E 399
 HDD  E 760 (-3.8A)
None
None
 0.62A 2avvE-1ye9E:
undetectable		 2avvE-1ye9E:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B9E_A_SAMA1201_0
(NOL1/NOP2/SUN DOMAIN
FAMILY, MEMBER 5
ISOFORM 2)		 1ye9 CATALASE HPII
(Escherichia
coli) 		5 / 12 GLY E 491
ASN E 492
LEU E 354
ASP E 405
SER E 498
 None
 1.46A 2b9eA-1ye9E:
undetectable		 2b9eA-1ye9E:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_G_SVRG506_3
(PHOSPHOLIPASE A2)		 1ye9 CATALASE HPII
(Escherichia
coli) 		3 / 3 PRO A 156
PHE A 152
LYS A 158
 None
 1.28A 3bjwG-1ye9A:
undetectable		 3bjwG-1ye9A:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HKU_A_TORA300_1
(CARBONIC ANHYDRASE 2)		 1ye9 CATALASE HPII
(Escherichia
coli) 		5 / 12 ALA A 220
VAL E 543
PHE E 527
LEU A 250
THR A 249
 None
 1.19A 3hkuA-1ye9A:
undetectable		 3hkuA-1ye9A:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I45_A_NIOA500_1
(TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
PROTEIN)		 1ye9 CATALASE HPII
(Escherichia
coli) 		4 / 8 PHE A 196
LEU A 153
PHE A 291
LEU E 336
 None
 1.01A 3i45A-1ye9A:
undetectable		 3i45A-1ye9A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ONN_A_ACTA271_0
(PROTEIN SSM1)		 1ye9 CATALASE HPII
CATALASE HPII
(Escherichia
coli;
Escherichia
coli) 		4 / 5 GLY E 480
GLU A 193
GLY E 476
PRO E 398
 None
 1.08A 3onnA-1ye9E:
undetectable		 3onnA-1ye9E:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_A_RTZA2_1
(CYTOCHROME P450 2D6)		 1ye9 CATALASE HPII
(Escherichia
coli) 		5 / 11 LEU A 279
THR A 287
VAL A 289
LEU E 336
PHE A 138
 None
 1.22A 3tbgA-1ye9A:
undetectable		 3tbgA-1ye9A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA500_2
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 1ye9 CATALASE HPII
(Escherichia
coli) 		4 / 4 LEU A 153
LEU A 198
GLN A 139
GLU E 335
 None
 1.27A 4i41A-1ye9A:
1.5		 4i41A-1ye9A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JKS_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 1ye9 CATALASE HPII
(Escherichia
coli) 		4 / 4 SER E 414
LEU E 408
TYR E 415
PRO A 215
 HDD  E 760 (-2.7A)
None
HDD  E 760 (-3.8A)
None
 1.49A 4jksB-1ye9E:
undetectable		 4jksB-1ye9E:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LAJ_B_ACAB512_1
(HIV-1 YU2 GP120
ENVELOPE
GLYCOPROTEIN)		 1ye9 CATALASE HPII
(Escherichia
coli) 		4 / 6 GLY A 200
ASP A 197
PRO E 393
ARG E 411
 HDD  E 760 (-3.8A)
None
None
HDD  E 760 (-3.8A)
 1.10A 4lajA-1ye9A:
undetectable
4lajB-1ye9A:
undetectable		 4lajA-1ye9A:
19.84
4lajB-1ye9A:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LAJ_B_ACAB512_1
(HIV-1 YU2 GP120
ENVELOPE
GLYCOPROTEIN)		 1ye9 CATALASE HPII
(Escherichia
coli) 		4 / 6 GLY A 273
ASP A 197
PRO E 393
ARG E 411
 None
None
None
HDD  E 760 (-3.8A)
 1.06A 4lajA-1ye9A:
undetectable
4lajB-1ye9A:
undetectable		 4lajA-1ye9A:
19.84
4lajB-1ye9A:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LUF_A_ACTA605_0
(SERUM ALBUMIN)		 1ye9 CATALASE HPII
CATALASE HPII
(Escherichia
coli;
Escherichia
coli) 		4 / 4 ALA A 133
HIS A 135
PHE A 163
LEU E 375
 None
 0.92A 4lufA-1ye9A:
0.0		 4lufA-1ye9A:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LUH_A_ACTA609_0
(SERUM ALBUMIN)		 1ye9 CATALASE HPII
CATALASE HPII
(Escherichia
coli;
Escherichia
coli) 		4 / 4 ALA A 133
HIS A 135
PHE A 163
LEU E 375
 None
 0.91A 4luhA-1ye9A:
0.0		 4luhA-1ye9A:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_H_377H401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1ye9 CATALASE HPII
(Escherichia
coli) 		4 / 6 ASN E 404
GLU E 346
GLU E 343
TYR E 485
 None
 1.44A 4twdG-1ye9E:
undetectable
4twdH-1ye9E:
undetectable		 4twdG-1ye9E:
24.38
4twdH-1ye9E:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UHX_A_RTZA3009_1
(ALDEHYDE OXIDASE)		 1ye9 CATALASE HPII
(Escherichia
coli) 		4 / 8 HIS E 522
GLU E 519
ARG E 521
PRO E 517
 None
 1.18A 4uhxA-1ye9E:
undetectable		 4uhxA-1ye9E:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		 1ye9 CATALASE HPII
(Escherichia
coli) 		4 / 6 LEU E 408
ASP E 405
TYR E 415
LEU E 412
 None
None
HDD  E 760 (-3.8A)
None
 1.04A 4wozA-1ye9E:
undetectable
4wozB-1ye9E:
undetectable		 4wozA-1ye9E:
20.45
4wozB-1ye9E:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_C_STRC603_2
(CYTOCHROME P450
21-HYDROXYLASE)		 1ye9 CATALASE HPII
(Escherichia
coli) 		3 / 3 LEU E 552
VAL E 544
ASP E 545
 None
 0.67A 4y8wC-1ye9E:
undetectable		 4y8wC-1ye9E:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXQ_A_NIZA808_1
(CATALASE-PEROXIDASE)		 1ye9 CATALASE HPII
(Escherichia
coli) 		4 / 8 ARG E 422
GLY E 424
GLN E 419
LEU E 423
 HDD  E 760 ( 4.5A)
None
HDD  E 760 (-3.9A)
None
 0.95A 5sxqA-1ye9E:
undetectable		 5sxqA-1ye9E:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXT_A_NIZA807_1
(CATALASE-PEROXIDASE)		 1ye9 CATALASE HPII
(Escherichia
coli) 		4 / 8 ARG E 422
GLY E 424
GLN E 419
LEU E 423
 HDD  E 760 ( 4.5A)
None
HDD  E 760 (-3.9A)
None
 0.89A 5sxtA-1ye9E:
undetectable		 5sxtA-1ye9E:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXT_B_NIZB808_1
(CATALASE-PEROXIDASE)		 1ye9 CATALASE HPII
(Escherichia
coli) 		4 / 8 ARG E 422
GLY E 424
GLN E 419
LEU E 423
 HDD  E 760 ( 4.5A)
None
HDD  E 760 (-3.9A)
None
 0.89A 5sxtB-1ye9E:
undetectable		 5sxtB-1ye9E:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYJ_B_NIZB809_1
(CATALASE-PEROXIDASE)		 1ye9 CATALASE HPII
(Escherichia
coli) 		4 / 8 ARG E 422
GLY E 424
GLN E 419
LEU E 423
 HDD  E 760 ( 4.5A)
None
HDD  E 760 (-3.9A)
None
 0.85A 5syjB-1ye9E:
undetectable		 5syjB-1ye9E:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6J21_A_GBQA1201_0
(SUBSTANCE-P
RECEPTOR,ENDOLYSIN)		 1ye9 CATALASE HPII
(Escherichia
coli) 		5 / 12 ASN A 252
VAL A 127
HIS A 236
PHE A 217
PHE A 239
 None
HDD  E 760 (-4.3A)
None
None
None
 1.32A 6j21A-1ye9A:
undetectable		 6j21A-1ye9A:
18.29