SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1yem'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_B_SAMB200_0
(METHIONINE REPRESSOR)		 1yem CONSERVED
HYPOTHETICAL PROTEIN
PFU-838710-001
(Pyrococcus
furiosus) 		5 / 11 GLU A   2
GLU A 161
ARG A 157
LEU A 162
GLU A 155
 None
 1.48A 1mjqA-1yemA:
undetectable
1mjqB-1yemA:
undetectable		 1mjqA-1yemA:
20.57
1mjqB-1yemA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOW_A_THAA400_1
(HISTAMINE
N-METHYLTRANSFERASE)		 1yem CONSERVED
HYPOTHETICAL PROTEIN
PFU-838710-001
(Pyrococcus
furiosus) 		4 / 7 GLU A  29
GLN A  31
TYR A 159
GLU A   4
 None
None
UNX  A 202 ( 4.5A)
UNX  A 204 ( 4.9A)
 1.01A 2aowA-1yemA:
undetectable		 2aowA-1yemA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AW1_A_COXA264_1
(CARBONIC ANHYDRASE
II)		 1yem CONSERVED
HYPOTHETICAL PROTEIN
PFU-838710-001
(Pyrococcus
furiosus) 		5 / 12 VAL A 124
LEU A 112
VAL A 114
LEU A  18
THR A  17
 None
 0.97A 2aw1A-1yemA:
undetectable		 2aw1A-1yemA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_C_ACTC608_0
(GBAA_1210 PROTEIN)		 1yem CONSERVED
HYPOTHETICAL PROTEIN
PFU-838710-001
(Pyrococcus
furiosus) 		4 / 5 GLU A  72
ARG A 102
ARG A  47
GLU A  74
 UNX  A 205 ( 4.0A)
UNX  A 204 (-3.6A)
UNX  A 205 ( 3.8A)
UNX  A 205 ( 4.9A)
 0.96A 3tj7C-1yemA:
13.5		 3tj7C-1yemA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UGR_A_IMNA2001_2
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 1yem CONSERVED
HYPOTHETICAL PROTEIN
PFU-838710-001
(Pyrococcus
furiosus) 		4 / 7 ASN A  19
TYR A  28
PRO A  23
TYR A 105
 None
 1.00A 3ugrA-1yemA:
undetectable		 3ugrA-1yemA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 1yem CONSERVED
HYPOTHETICAL PROTEIN
PFU-838710-001
(Pyrococcus
furiosus) 		4 / 7 ASP A 125
ASP A  33
ASN A 115
GLU A   4
 None
None
None
UNX  A 204 ( 4.9A)
 1.19A 4feuB-1yemA:
undetectable		 4feuB-1yemA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K13_A_ETSA304_1
(CARBONIC ANHYDRASE 2)		 1yem CONSERVED
HYPOTHETICAL PROTEIN
PFU-838710-001
(Pyrococcus
furiosus) 		5 / 12 VAL A 124
LEU A 112
VAL A 114
LEU A  18
THR A  17
 None
 0.96A 4k13A-1yemA:
undetectable		 4k13A-1yemA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2W_A_ETSA302_1
(CARBONIC ANHYDRASE 2)		 1yem CONSERVED
HYPOTHETICAL PROTEIN
PFU-838710-001
(Pyrococcus
furiosus) 		5 / 12 VAL A 124
LEU A 112
VAL A 114
LEU A  18
THR A  17
 None
 0.95A 4m2wA-1yemA:
undetectable		 4m2wA-1yemA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XIW_G_AZMG402_1
(CARBONIC ANHYDRASE,
ALPHA TYPE)		 1yem CONSERVED
HYPOTHETICAL PROTEIN
PFU-838710-001
(Pyrococcus
furiosus) 		5 / 12 VAL A 124
LEU A 112
VAL A 114
LEU A  18
THR A  17
 None
 0.86A 4xiwG-1yemA:
undetectable		 4xiwG-1yemA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_A_SVRA205_2
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 1yem CONSERVED
HYPOTHETICAL PROTEIN
PFU-838710-001
(Pyrococcus
furiosus) 		4 / 6 PHE A  14
LEU A 107
ASN A  22
PRO A  23
 None
 1.08A 4yv5B-1yemA:
undetectable		 4yv5B-1yemA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_B_SVRB207_1
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 1yem CONSERVED
HYPOTHETICAL PROTEIN
PFU-838710-001
(Pyrococcus
furiosus) 		4 / 6 PHE A  14
LEU A 107
ASN A  22
PRO A  23
 None
 1.09A 4yv5A-1yemA:
undetectable		 4yv5A-1yemA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_B_SORB1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 1yem CONSERVED
HYPOTHETICAL PROTEIN
PFU-838710-001
(Pyrococcus
furiosus) 		4 / 7 ARG A  47
ASP A  33
ILE A  98
TYR A 159
 UNX  A 205 ( 3.8A)
None
None
UNX  A 202 ( 4.5A)
 1.40A 5a06B-1yemA:
undetectable		 5a06B-1yemA:
18.91