SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1yf2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CD2_A_FOLA307_0
(DIHYDROFOLATE
REDUCTASE)		 1yf2 TYPE I
RESTRICTION-MODIFICA
TION ENZYME, S
SUBUNIT
(Methanocaldococc
us
jannaschii) 		5 / 12 ALA A 135
LEU A 417
PRO A 166
LEU A 125
TYR A 141
 None
 1.06A 1cd2A-1yf2A:
undetectable		 1cd2A-1yf2A:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRF_A_FOLA187_0
(DIHYDROFOLATE
REDUCTASE)		 1yf2 TYPE I
RESTRICTION-MODIFICA
TION ENZYME, S
SUBUNIT
(Methanocaldococc
us
jannaschii) 		5 / 12 ALA A 135
LEU A 417
PRO A 166
LEU A 125
TYR A 141
 None
 1.07A 1drfA-1yf2A:
undetectable		 1drfA-1yf2A:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSH_C_MK1C402_2
(HIV-II PROTEASE)		 1yf2 TYPE I
RESTRICTION-MODIFICA
TION ENZYME, S
SUBUNIT
(Methanocaldococc
us
jannaschii) 		4 / 8 ALA A  94
GLY A 117
ILE A 118
ILE A  59
 None
 0.67A 1hshD-1yf2A:
undetectable		 1hshD-1yf2A:
12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JKH_A_EFZA999_1
(HIV-1 RT, A-CHAIN
HIV-1 RT, B-CHAIN)		 1yf2 TYPE I
RESTRICTION-MODIFICA
TION ENZYME, S
SUBUNIT
(Methanocaldococc
us
jannaschii) 		5 / 11 LEU A 368
VAL A 311
VAL A 308
GLY A 309
LEU A 327
 None
 1.24A 1jkhA-1yf2A:
undetectable
1jkhB-1yf2A:
undetectable		 1jkhA-1yf2A:
22.88
1jkhB-1yf2A:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MEH_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 1yf2 TYPE I
RESTRICTION-MODIFICA
TION ENZYME, S
SUBUNIT
(Methanocaldococc
us
jannaschii) 		5 / 10 ASP A 265
ASN A 259
ILE A 258
GLY A 256
GLU A 279
 None
 1.00A 1mehA-1yf2A:
undetectable		 1mehA-1yf2A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MEI_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 1yf2 TYPE I
RESTRICTION-MODIFICA
TION ENZYME, S
SUBUNIT
(Methanocaldococc
us
jannaschii) 		4 / 8 ASP A 265
ASN A 259
ILE A 258
GLU A 279
 None
 0.79A 1meiA-1yf2A:
undetectable		 1meiA-1yf2A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CD2_A_FOLA307_0
(DIHYDROFOLATE
REDUCTASE)		 1yf2 TYPE I
RESTRICTION-MODIFICA
TION ENZYME, S
SUBUNIT
(Methanocaldococc
us
jannaschii) 		5 / 12 ALA A 135
LEU A 417
PRO A 166
LEU A 125
TYR A 141
 None
 1.03A 2cd2A-1yf2A:
undetectable		 2cd2A-1yf2A:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2L8M_A_CAMA415_0
(CAMPHOR
5-MONOOXYGENASE)		 1yf2 TYPE I
RESTRICTION-MODIFICA
TION ENZYME, S
SUBUNIT
(Methanocaldococc
us
jannaschii) 		5 / 9 THR A 111
LEU A  92
VAL A  91
VAL A 158
ILE A  32
 None
 1.46A 2l8mA-1yf2A:
undetectable		 2l8mA-1yf2A:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M2O_B_DHIB24_0
(INSULIN B CHAIN)		 1yf2 TYPE I
RESTRICTION-MODIFICA
TION ENZYME, S
SUBUNIT
(Methanocaldococc
us
jannaschii) 		4 / 6 GLY A 242
PHE A 320
PRO A 263
THR A 304
 None
 1.10A 2m2oB-1yf2A:
undetectable		 2m2oB-1yf2A:
5.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWC_B_SAMB501_0
(SPERMIDINE SYNTHASE)		 1yf2 TYPE I
RESTRICTION-MODIFICA
TION ENZYME, S
SUBUNIT
(Methanocaldococc
us
jannaschii) 		5 / 12 LEU A 134
ILE A  56
ILE A  99
VAL A 158
GLY A  97
 None
 1.01A 3bwcB-1yf2A:
undetectable		 3bwcB-1yf2A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKW_B_DR7B100_2
(PROTEASE)		 1yf2 TYPE I
RESTRICTION-MODIFICA
TION ENZYME, S
SUBUNIT
(Methanocaldococc
us
jannaschii) 		5 / 12 GLY A  36
ALA A  83
ILE A  85
VAL A  86
ILE A  73
 None
 0.86A 3ekwB-1yf2A:
undetectable		 3ekwB-1yf2A:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_A_CELA682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1yf2 TYPE I
RESTRICTION-MODIFICA
TION ENZYME, S
SUBUNIT
(Methanocaldococc
us
jannaschii) 		4 / 8 LEU A  25
LEU A 153
TYR A 141
ILE A 118
 None
 0.84A 3ln1A-1yf2A:
undetectable		 3ln1A-1yf2A:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NV6_A_CAMA422_0
(CYTOCHROME P450)		 1yf2 TYPE I
RESTRICTION-MODIFICA
TION ENZYME, S
SUBUNIT
(Methanocaldococc
us
jannaschii) 		3 / 3 GLY A 100
ILE A 157
VAL A 158
 None
 0.41A 3nv6A-1yf2A:
0.1		 3nv6A-1yf2A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_C_DSFC320_1
(GLR4197 PROTEIN)		 1yf2 TYPE I
RESTRICTION-MODIFICA
TION ENZYME, S
SUBUNIT
(Methanocaldococc
us
jannaschii) 		4 / 8 ILE A 236
ILE A 233
VAL A 335
ILE A 300
 None
 0.85A 3p4wC-1yf2A:
1.7		 3p4wC-1yf2A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3O_A_DLUA399_1
(PFV INTEGRASE)		 1yf2 TYPE I
RESTRICTION-MODIFICA
TION ENZYME, S
SUBUNIT
(Methanocaldococc
us
jannaschii) 		4 / 7 ASP A 227
PRO A 376
GLN A 381
GLU A 380
 None
 1.24A 3s3oA-1yf2A:
undetectable		 3s3oA-1yf2A:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LMN_A_EUIA503_2
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 1yf2 TYPE I
RESTRICTION-MODIFICA
TION ENZYME, S
SUBUNIT
(Methanocaldococc
us
jannaschii) 		3 / 3 ASP A 265
VAL A 313
ASN A 321
 None
 0.73A 4lmnA-1yf2A:
undetectable		 4lmnA-1yf2A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DPD_A_SAMA601_0
(PROTEIN LYSINE
METHYLTRANSFERASE 1)		 1yf2 TYPE I
RESTRICTION-MODIFICA
TION ENZYME, S
SUBUNIT
(Methanocaldococc
us
jannaschii) 		5 / 12 GLU A 352
GLY A 309
LEU A 266
SER A 267
ILE A 302
 None
 1.14A 5dpdA-1yf2A:
undetectable		 5dpdA-1yf2A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_G_FK5G201_1
(FK506-BINDING
PROTEIN 1)		 1yf2 TYPE I
RESTRICTION-MODIFICA
TION ENZYME, S
SUBUNIT
(Methanocaldococc
us
jannaschii) 		3 / 3 ILE A  51
PRO A  52
ILE A  73
 None
 0.36A 5hw8F-1yf2A:
undetectable		 5hw8F-1yf2A:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UIG_A_EDTA501_0
(ADENOSINE RECEPTOR
A2A,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A2A)		 1yf2 TYPE I
RESTRICTION-MODIFICA
TION ENZYME, S
SUBUNIT
(Methanocaldococc
us
jannaschii) 		4 / 6 ASN A 112
THR A 111
ILE A  59
GLU A  57
 None
 1.30A 5uigA-1yf2A:
undetectable		 5uigA-1yf2A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AZ3_1_PAR11803_1
(RRNA ALPHA
RIBOSOMAL PROTEIN
EL18)		 1yf2 TYPE I
RESTRICTION-MODIFICA
TION ENZYME, S
SUBUNIT
(Methanocaldococc
us
jannaschii) 		3 / 3 SER A 366
LYS A 365
SER A 364
 None
 0.81A 6az3P-1yf2A:
undetectable		 6az3P-1yf2A:
12.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSG_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 1yf2 TYPE I
RESTRICTION-MODIFICA
TION ENZYME, S
SUBUNIT
(Methanocaldococc
us
jannaschii) 		5 / 10 LEU A 368
VAL A 311
VAL A 308
GLY A 309
LEU A 327
 None
 1.23A 6bsgA-1yf2A:
undetectable		 6bsgA-1yf2A:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSI_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 1yf2 TYPE I
RESTRICTION-MODIFICA
TION ENZYME, S
SUBUNIT
(Methanocaldococc
us
jannaschii) 		5 / 10 LEU A 368
VAL A 311
VAL A 308
GLY A 309
LEU A 327
 None
 1.22A 6bsiA-1yf2A:
0.0		 6bsiA-1yf2A:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSJ_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 1yf2 TYPE I
RESTRICTION-MODIFICA
TION ENZYME, S
SUBUNIT
(Methanocaldococc
us
jannaschii) 		5 / 10 LEU A 368
VAL A 311
VAL A 308
GLY A 309
LEU A 327
 None
 1.22A 6bsjA-1yf2A:
undetectable		 6bsjA-1yf2A:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_A_DAHA123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 1yf2 TYPE I
RESTRICTION-MODIFICA
TION ENZYME, S
SUBUNIT
(Methanocaldococc
us
jannaschii) 		5 / 9 LEU A 417
THR A 418
GLY A  14
ILE A  13
PHE A 129
 None
 1.00A 6ebpA-1yf2A:
undetectable		 6ebpA-1yf2A:
10.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_B_DAHB123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 1yf2 TYPE I
RESTRICTION-MODIFICA
TION ENZYME, S
SUBUNIT
(Methanocaldococc
us
jannaschii) 		5 / 10 LEU A 417
THR A 418
GLY A  14
ILE A  13
PHE A 129
 None
 1.00A 6ebpB-1yf2A:
undetectable		 6ebpB-1yf2A:
10.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_C_DAHC123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 1yf2 TYPE I
RESTRICTION-MODIFICA
TION ENZYME, S
SUBUNIT
(Methanocaldococc
us
jannaschii) 		5 / 10 LEU A 417
THR A 418
GLY A  14
ILE A  13
PHE A 129
 None
 1.04A 6ebpC-1yf2A:
undetectable		 6ebpC-1yf2A:
10.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_A_DAHA123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 1yf2 TYPE I
RESTRICTION-MODIFICA
TION ENZYME, S
SUBUNIT
(Methanocaldococc
us
jannaschii) 		5 / 11 LEU A 417
THR A 418
GLY A  14
ILE A  13
PHE A 129
 None
 1.02A 6ebzA-1yf2A:
undetectable		 6ebzA-1yf2A:
10.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_B_DAHB123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 1yf2 TYPE I
RESTRICTION-MODIFICA
TION ENZYME, S
SUBUNIT
(Methanocaldococc
us
jannaschii) 		5 / 11 LEU A 417
THR A 418
GLY A  14
ILE A  13
PHE A 129
 None
 1.04A 6ebzB-1yf2A:
undetectable		 6ebzB-1yf2A:
10.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_C_DAHC123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 1yf2 TYPE I
RESTRICTION-MODIFICA
TION ENZYME, S
SUBUNIT
(Methanocaldococc
us
jannaschii) 		5 / 11 LEU A 417
THR A 418
GLY A  14
ILE A  13
PHE A 129
 None
 1.03A 6ebzC-1yf2A:
undetectable		 6ebzC-1yf2A:
10.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_D_DAHD123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 1yf2 TYPE I
RESTRICTION-MODIFICA
TION ENZYME, S
SUBUNIT
(Methanocaldococc
us
jannaschii) 		5 / 11 LEU A 417
THR A 418
GLY A  14
ILE A  13
PHE A 129
 None
 1.02A 6ebzD-1yf2A:
undetectable		 6ebzD-1yf2A:
10.03