SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1yf8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MRJ_A_ADNA300_1
(ALPHA-TRICHOSANTHIN)		 1yf8 BETA-GALACTOSIDE-SPE
CIFIC LECTIN 4
(Viscum
album) 		4 / 8 GLY A 108
ILE A 154
SER A 158
GLU A 159
 None
None
None
P6C  A1001 ( 4.4A)
 0.56A 1mrjA-1yf8A:
31.4		 1mrjA-1yf8A:
35.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MRJ_A_ADNA300_1
(ALPHA-TRICHOSANTHIN)		 1yf8 BETA-GALACTOSIDE-SPE
CIFIC LECTIN 4
(Viscum
album) 		4 / 8 ILE A 154
SER A 158
GLU A 159
ARG A 162
 None
None
P6C  A1001 ( 4.4A)
P6C  A1001 (-2.6A)
 0.48A 1mrjA-1yf8A:
31.4		 1mrjA-1yf8A:
35.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MRJ_A_ADNA300_1
(ALPHA-TRICHOSANTHIN)		 1yf8 BETA-GALACTOSIDE-SPE
CIFIC LECTIN 4
(Viscum
album) 		4 / 8 TYR A  75
ILE A 154
SER A 158
GLU A 159
 P6C  A1001 (-4.6A)
None
None
P6C  A1001 ( 4.4A)
 0.88A 1mrjA-1yf8A:
31.4		 1mrjA-1yf8A:
35.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_1
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1yf8 BETA-GALACTOSIDE-SPE
CIFIC LECTIN 4
(Viscum
album) 		4 / 4 ILE A 127
LEU A 130
VAL A 134
ALA A  81
 None
 1.01A 1mz9A-1yf8A:
undetectable		 1mz9A-1yf8A:
10.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QEL_B_QELB1_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE [NMDA]
RECEPTOR SUBUNIT
EPSILON-2)		 1yf8 BETA-GALACTOSIDE-SPE
CIFIC LECTIN 4
(Viscum
album) 		5 / 11 LEU A 233
ALA A 161
ILE A  21
PHE A  18
PRO A  38
 None
 1.28A 3qelA-1yf8A:
undetectable
3qelB-1yf8A:
undetectable		 3qelA-1yf8A:
20.36
3qelB-1yf8A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_A_ZPCA1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1yf8 BETA-GALACTOSIDE-SPE
CIFIC LECTIN 4
(Viscum
album) 		4 / 7 PHE A 208
VAL A 200
ILE A  37
ASN A  35
 None
 1.14A 4a97E-1yf8A:
undetectable		 4a97E-1yf8A:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_I_ZPCI1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1yf8 BETA-GALACTOSIDE-SPE
CIFIC LECTIN 4
(Viscum
album) 		4 / 7 PHE A 208
VAL A 200
ILE A  37
ASN A  35
 None
 1.10A 4a97H-1yf8A:
undetectable		 4a97H-1yf8A:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AFT_D_QMRD301_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 1yf8 BETA-GALACTOSIDE-SPE
CIFIC LECTIN 4
(Viscum
album) 		4 / 8 TYR A 185
VAL A 229
VAL A 200
ILE A 212
 None
 1.14A 4aftD-1yf8A:
undetectable
4aftE-1yf8A:
undetectable		 4aftD-1yf8A:
22.87
4aftE-1yf8A:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_A_GAIA407_0
(PROTEIN (ARGINASE))		 1yf8 BETA-GALACTOSIDE-SPE
CIFIC LECTIN 4
(Viscum
album) 		4 / 6 ARG A 169
LEU A 189
MET A 186
ASP A 183
 None
 1.05A 4cevA-1yf8A:
undetectable
4cevB-1yf8A:
undetectable		 4cevA-1yf8A:
24.06
4cevB-1yf8A:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_C_GAIC409_0
(PROTEIN (ARGINASE))		 1yf8 BETA-GALACTOSIDE-SPE
CIFIC LECTIN 4
(Viscum
album) 		4 / 6 MET A 186
ASP A 183
ARG A 169
LEU A 189
 None
 1.05A 4cevA-1yf8A:
undetectable
4cevC-1yf8A:
undetectable		 4cevA-1yf8A:
24.06
4cevC-1yf8A:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_D_GAID410_0
(PROTEIN (ARGINASE))		 1yf8 BETA-GALACTOSIDE-SPE
CIFIC LECTIN 4
(Viscum
album) 		4 / 6 ARG A 169
LEU A 189
MET A 186
ASP A 183
 None
 1.08A 4cevD-1yf8A:
undetectable
4cevE-1yf8A:
undetectable		 4cevD-1yf8A:
24.06
4cevE-1yf8A:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_F_GAIF411_0
(PROTEIN (ARGINASE))		 1yf8 BETA-GALACTOSIDE-SPE
CIFIC LECTIN 4
(Viscum
album) 		4 / 6 ARG A 169
LEU A 189
MET A 186
ASP A 183
 None
 1.07A 4cevE-1yf8A:
undetectable
4cevF-1yf8A:
undetectable		 4cevE-1yf8A:
24.06
4cevF-1yf8A:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_A_ACTA303_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 1yf8 BETA-GALACTOSIDE-SPE
CIFIC LECTIN 4
(Viscum
album) 		3 / 3 TYR A 110
HIS A 119
ARG A 120
 None
 1.09A 4htfA-1yf8A:
undetectable		 4htfA-1yf8A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J14_A_X2NA602_1
(CHOLESTEROL
24-HYDROXYLASE)		 1yf8 BETA-GALACTOSIDE-SPE
CIFIC LECTIN 4
(Viscum
album) 		5 / 10 ALA A 161
LEU A  24
PHE A  20
THR A  66
ALA A  68
 None
 1.10A 4j14A-1yf8A:
undetectable		 4j14A-1yf8A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PE5_B_QELB920_1
(GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 1
GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2B)		 1yf8 BETA-GALACTOSIDE-SPE
CIFIC LECTIN 4
(Viscum
album) 		5 / 10 LEU A 233
ALA A 161
ILE A  21
PHE A  18
PRO A  38
 None
 1.20A 4pe5A-1yf8A:
undetectable
4pe5B-1yf8A:
undetectable		 4pe5A-1yf8A:
13.98
4pe5B-1yf8A:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PE5_C_QELC939_1
(GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 1
GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2B)		 1yf8 BETA-GALACTOSIDE-SPE
CIFIC LECTIN 4
(Viscum
album) 		5 / 10 LEU A 233
ALA A 161
ILE A  21
PHE A  18
PRO A  38
 None
 1.20A 4pe5C-1yf8A:
undetectable
4pe5D-1yf8A:
undetectable		 4pe5C-1yf8A:
13.98
4pe5D-1yf8A:
13.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YP2_B_NCAB302_0
(RIBOSOME-INACTIVATIN
G PROTEIN MOMORDIN I)		 1yf8 BETA-GALACTOSIDE-SPE
CIFIC LECTIN 4
(Viscum
album) 		5 / 9 TYR A  75
GLY A 108
ILE A 154
GLU A 159
ARG A 162
 P6C  A1001 (-4.6A)
None
None
P6C  A1001 ( 4.4A)
P6C  A1001 (-2.6A)
 0.95A 4yp2B-1yf8A:
31.7		 4yp2B-1yf8A:
34.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5CF9_B_NCAB302_0
(RIBOSOME-INACTIVATIN
G PROTEIN MOMORDIN I)		 1yf8 BETA-GALACTOSIDE-SPE
CIFIC LECTIN 4
(Viscum
album) 		5 / 9 TYR A  75
GLY A 108
ILE A 154
GLU A 159
ARG A 162
 P6C  A1001 (-4.6A)
None
None
P6C  A1001 ( 4.4A)
P6C  A1001 (-2.6A)
 0.94A 5cf9B-1yf8A:
31.8		 5cf9B-1yf8A:
34.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_2_BEZ2801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 1yf8 BETA-GALACTOSIDE-SPE
CIFIC LECTIN 4
(Viscum
album) 		4 / 4 LEU A 181
ARG A 148
ILE A 123
ILE A 152
 None
 1.37A 5dzk2-1yf8A:
undetectable
5dzkM-1yf8A:
undetectable
5dzkN-1yf8A:
undetectable		 5dzk2-1yf8A:
8.33
5dzkM-1yf8A:
24.02
5dzkN-1yf8A:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWJ_B_QELB503_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2B)		 1yf8 BETA-GALACTOSIDE-SPE
CIFIC LECTIN 4
(Viscum
album) 		5 / 11 LEU A 233
ALA A 161
ILE A  21
PHE A  18
PRO A  38
 None
 1.29A 5ewjA-1yf8A:
undetectable
5ewjB-1yf8A:
undetectable		 5ewjA-1yf8A:
20.56
5ewjB-1yf8A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWJ_D_QELD503_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2B)		 1yf8 BETA-GALACTOSIDE-SPE
CIFIC LECTIN 4
(Viscum
album) 		5 / 12 LEU A 233
ALA A 161
ILE A  21
PHE A  18
PRO A  38
 None
 1.30A 5ewjC-1yf8A:
undetectable
5ewjD-1yf8A:
undetectable		 5ewjC-1yf8A:
20.56
5ewjD-1yf8A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_A_ACRA1481_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 1yf8 BETA-GALACTOSIDE-SPE
CIFIC LECTIN 4
(Viscum
album) 		4 / 6 SER A 109
ARG A 120
GLU A 114
TYR A 110
 P6C  A1001 (-3.5A)
None
None
None
 1.48A 5x7pA-1yf8A:
undetectable		 5x7pA-1yf8A:
11.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Z3J_A_NCAA302_0
(ABRIN A-CHAIN)		 1yf8 BETA-GALACTOSIDE-SPE
CIFIC LECTIN 4
(Viscum
album) 		5 / 6 TYR A  75
VAL A  76
ILE A 154
GLU A 159
ARG A 162
 P6C  A1001 (-4.6A)
None
None
P6C  A1001 ( 4.4A)
P6C  A1001 (-2.6A)
 0.64A 5z3jA-1yf8A:
33.8		 5z3jA-1yf8A:
39.85