SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1yfj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SKX_A_RFPA1_1
(ORPHAN NUCLEAR
RECEPTOR PXR)		 1yfj DNA ADENINE
METHYLASE
(Escherichia
virus
T4) 		5 / 12 VAL A  70
LEU A 103
PHE A 152
CYH A 147
ILE A 115
 None
 1.46A 1skxA-1yfjA:
0.0		 1skxA-1yfjA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DPM_A_SAMA300_0
(PROTEIN
(ADENINE-SPECIFIC
METHYLTRANSFERASE
DPNII 1))		 1yfj DNA ADENINE
METHYLASE
(Escherichia
virus
T4) 		5 / 12 GLY A   9
PHE A  32
GLY A  34
PHE A 157
PRO A 173
 None
SAH  A 401 (-4.2A)
SAH  A 401 (-3.2A)
SAH  A 401 (-4.8A)
SAH  A 401 (-4.0A)
 1.08A 2dpmA-1yfjA:
22.3		 2dpmA-1yfjA:
28.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DPM_A_SAMA300_0
(PROTEIN
(ADENINE-SPECIFIC
METHYLTRANSFERASE
DPNII 1))		 1yfj DNA ADENINE
METHYLASE
(Escherichia
virus
T4) 		6 / 12 LYS A  11
PHE A  32
GLY A  34
GLY A  35
PHE A 157
PRO A 173
 SAH  A 401 (-4.8A)
SAH  A 401 (-4.2A)
SAH  A 401 (-3.2A)
SAH  A 401 (-3.4A)
SAH  A 401 (-4.8A)
SAH  A 401 (-4.0A)
 0.49A 2dpmA-1yfjA:
22.3		 2dpmA-1yfjA:
28.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M2P_B_DHIB24_0
(INSULIN B CHAIN)		 1yfj DNA ADENINE
METHYLASE
(Escherichia
virus
T4) 		3 / 3 TYR A  25
GLY A 165
PHE A 167
 None
 0.57A 2m2pB-1yfjA:
undetectable		 2m2pB-1yfjA:
10.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PLW_A_SAMA203_1
(RIBOSOMAL RNA
METHYLTRANSFERASE,
PUTATIVE)		 1yfj DNA ADENINE
METHYLASE
(Escherichia
virus
T4) 		3 / 3 SER A  37
ASP A  50
ASP A 171
 SAH  A 401 (-2.4A)
SAH  A 401 (-2.9A)
SAH  A 401 (-3.8A)
 0.41A 2plwA-1yfjA:
9.1		 2plwA-1yfjA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K8M_B_ACRB820_1
(ALPHA-AMYLASE, SUSG)		 1yfj DNA ADENINE
METHYLASE
(Escherichia
virus
T4) 		4 / 7 GLU A 189
LEU A 209
TRP A 226
ASN A 211
 None
 1.15A 3k8mB-1yfjA:
undetectable		 3k8mB-1yfjA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KZ7_A_RAPA225_1
(FK506-BINDING
PROTEIN 3)		 1yfj DNA ADENINE
METHYLASE
(Escherichia
virus
T4) 		5 / 10 TYR A 169
ASP A 171
LEU A  18
LYS A 233
ILE A 257
 None
SAH  A 401 (-3.8A)
None
None
None
 1.16A 3kz7A-1yfjA:
undetectable		 3kz7A-1yfjA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_A_SAMA6735_1
(16S RRNA METHYLASE)		 1yfj DNA ADENINE
METHYLASE
(Escherichia
virus
T4) 		3 / 3 ASP A 171
GLU A 190
SER A  13
 SAH  A 401 (-3.8A)
None
None
 0.53A 3p2kA-1yfjA:
5.0		 3p2kA-1yfjA:
24.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P73_A_ACTA275_0
(MHC RFP-Y CLASS I
ALPHA CHAIN)		 1yfj DNA ADENINE
METHYLASE
(Escherichia
virus
T4) 		3 / 3 ILE A 162
VAL A  29
ARG A  27
 None
 0.76A 3p73A-1yfjA:
undetectable		 3p73A-1yfjA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HAJ_A_DXCA75_0
(PPCA)		 1yfj DNA ADENINE
METHYLASE
(Escherichia
virus
T4) 		4 / 7 ILE A  55
LEU A 103
PHE A 123
GLY A 110
 None
 0.96A 4hajA-1yfjA:
undetectable		 4hajA-1yfjA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTM_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 1yfj DNA ADENINE
METHYLASE
(Escherichia
virus
T4) 		5 / 12 GLY A   9
GLY A  34
ILE A  51
PRO A 173
TYR A 174
 None
SAH  A 401 (-3.2A)
SAH  A 401 (-3.6A)
SAH  A 401 (-4.0A)
None
 1.05A 4rtmA-1yfjA:
26.3		 4rtmA-1yfjA:
27.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTM_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 1yfj DNA ADENINE
METHYLASE
(Escherichia
virus
T4) 		5 / 12 GLY A   9
PHE A  32
GLY A  34
ILE A  51
PRO A 173
 None
SAH  A 401 (-4.2A)
SAH  A 401 (-3.2A)
SAH  A 401 (-3.6A)
SAH  A 401 (-4.0A)
 0.47A 4rtmA-1yfjA:
26.3		 4rtmA-1yfjA:
27.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTP_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 1yfj DNA ADENINE
METHYLASE
(Escherichia
virus
T4) 		6 / 12 PHE A  32
GLY A  34
SER A  37
ILE A  51
ASP A 171
PRO A 173
 SAH  A 401 (-4.2A)
SAH  A 401 (-3.2A)
SAH  A 401 (-2.4A)
SAH  A 401 (-3.6A)
SAH  A 401 (-3.8A)
SAH  A 401 (-4.0A)
 0.34A 4rtpA-1yfjA:
25.8		 4rtpA-1yfjA:
27.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTR_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 1yfj DNA ADENINE
METHYLASE
(Escherichia
virus
T4) 		5 / 11 GLY A   9
ASP A  50
ASP A 171
PRO A 173
TYR A 174
 None
SAH  A 401 (-2.9A)
SAH  A 401 (-3.8A)
SAH  A 401 (-4.0A)
None
 0.79A 4rtrA-1yfjA:
26.2		 4rtrA-1yfjA:
27.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTR_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 1yfj DNA ADENINE
METHYLASE
(Escherichia
virus
T4) 		6 / 11 GLY A   9
PHE A  32
ASP A  50
ILE A  51
ASP A 171
PRO A 173
 None
SAH  A 401 (-4.2A)
SAH  A 401 (-2.9A)
SAH  A 401 (-3.6A)
SAH  A 401 (-3.8A)
SAH  A 401 (-4.0A)
 0.37A 4rtrA-1yfjA:
26.2		 4rtrA-1yfjA:
27.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTS_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 1yfj DNA ADENINE
METHYLASE
(Escherichia
virus
T4) 		5 / 12 GLY A   9
GLY A  34
ASP A  50
PRO A 173
TYR A 174
 None
SAH  A 401 (-3.2A)
SAH  A 401 (-2.9A)
SAH  A 401 (-4.0A)
None
 0.75A 4rtsA-1yfjA:
19.1		 4rtsA-1yfjA:
27.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTS_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 1yfj DNA ADENINE
METHYLASE
(Escherichia
virus
T4) 		7 / 12 GLY A   9
PHE A  32
GLY A  34
ASP A  50
ILE A  51
ASP A 171
PRO A 173
 None
SAH  A 401 (-4.2A)
SAH  A 401 (-3.2A)
SAH  A 401 (-2.9A)
SAH  A 401 (-3.6A)
SAH  A 401 (-3.8A)
SAH  A 401 (-4.0A)
 0.42A 4rtsA-1yfjA:
19.1		 4rtsA-1yfjA:
27.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_H_SAMH301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 1yfj DNA ADENINE
METHYLASE
(Escherichia
virus
T4) 		5 / 12 ASP A 171
PRO A 173
LYS A  11
PHE A  32
GLY A  34
 SAH  A 401 (-3.8A)
SAH  A 401 (-4.0A)
SAH  A 401 (-4.8A)
SAH  A 401 (-4.2A)
SAH  A 401 (-3.2A)
 0.75A 5hfjH-1yfjA:
2.3		 5hfjH-1yfjA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC0_A_RBFA303_2
(RIBOFLAVIN
TRANSPORTER RIBU)		 1yfj DNA ADENINE
METHYLASE
(Escherichia
virus
T4) 		3 / 3 LYS A  11
LEU A  40
ILE A   5
 SAH  A 401 (-4.8A)
None
None
 0.78A 5kc0A-1yfjA:
undetectable		 5kc0A-1yfjA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9M_A_NIOA401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 1yfj DNA ADENINE
METHYLASE
(Escherichia
virus
T4) 		4 / 8 LEU A  31
VAL A 170
VAL A 168
PHE A 207
 None
 0.77A 5y9mA-1yfjA:
undetectable		 5y9mA-1yfjA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 1yfj DNA ADENINE
METHYLASE
(Escherichia
virus
T4) 		3 / 3 LEU A 175
ASN A 195
LEU A 209
 None
 0.70A 6exiA-1yfjA:
3.7		 6exiA-1yfjA:
14.06