SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1yfm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_2
(ADENOSINE DEAMINASE)		 1yfm FUMARASE
(Saccharomyces
cerevisiae) 		4 / 4 HIS A 296
LEU A  70
LEU A 395
LEU A 306
 None
 0.94A 1a4lD-1yfmA:
undetectable		 1a4lD-1yfmA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQE_A_FLPA1650_1
(PROTEIN
(PROSTAGLANDIN H2
SYNTHASE-1))		 1yfm FUMARASE
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 185
ILE A 237
ALA A 241
SER A 243
LEU A 244
 None
 0.99A 1cqeA-1yfmA:
1.5		 1cqeA-1yfmA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQE_B_FLPB2650_1
(PROTEIN
(PROSTAGLANDIN H2
SYNTHASE-1))		 1yfm FUMARASE
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 185
ILE A 237
ALA A 241
SER A 243
LEU A 244
 None
 0.98A 1cqeB-1yfmA:
undetectable		 1cqeB-1yfmA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBY_A_9CRA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1yfm FUMARASE
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 391
ALA A 176
ALA A 177
GLN A 180
LEU A  70
 None
 1.05A 1fbyA-1yfmA:
2.3		 1fbyA-1yfmA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBY_B_9CRB1500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1yfm FUMARASE
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 391
ALA A 176
ALA A 177
GLN A 180
LEU A  70
 None
 1.03A 1fbyB-1yfmA:
undetectable		 1fbyB-1yfmA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G60_A_SAMA500_0
(ADENINE-SPECIFIC
METHYLTRANSFERASE
MBOIIA)		 1yfm FUMARASE
(Saccharomyces
cerevisiae) 		5 / 12 ASN A 393
PHE A 120
GLY A 123
SER A 124
THR A 126
 None
 1.41A 1g60A-1yfmA:
undetectable		 1g60A-1yfmA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_B_RBFB502_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 1yfm FUMARASE
(Saccharomyces
cerevisiae) 		5 / 11 HIS A 174
GLY A 125
SER A 124
LEU A 383
HIS A 296
 None
 1.46A 1kyvA-1yfmA:
undetectable
1kyvB-1yfmA:
undetectable		 1kyvA-1yfmA:
14.81
1kyvB-1yfmA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P93_A_DEXA1999_1
(GLUCOCORTICOID
RECEPTOR)		 1yfm FUMARASE
(Saccharomyces
cerevisiae) 		5 / 12 ASN A 138
GLY A  47
MET A 130
ARG A  52
ILE A 141
 None
 1.47A 1p93A-1yfmA:
undetectable		 1p93A-1yfmA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T9W_A_NFNA6001_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 1yfm FUMARASE
(Saccharomyces
cerevisiae) 		3 / 3 SER A 325
GLY A 324
ARG A 211
 None
 0.66A 1t9wA-1yfmA:
0.0		 1t9wA-1yfmA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XIU_A_9CRA201_1
(RXR-LIKE PROTEIN)		 1yfm FUMARASE
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 391
ALA A 176
ALA A 177
GLN A 180
LEU A  70
 None
 0.98A 1xiuA-1yfmA:
undetectable		 1xiuA-1yfmA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_A_RBFA300_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 1yfm FUMARASE
(Saccharomyces
cerevisiae) 		5 / 11 GLY A 125
SER A 124
LEU A 383
HIS A 296
HIS A 174
 None
 1.46A 2a58A-1yfmA:
undetectable
2a58E-1yfmA:
undetectable		 2a58A-1yfmA:
14.81
2a58E-1yfmA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_D_RBFD303_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 1yfm FUMARASE
(Saccharomyces
cerevisiae) 		5 / 11 HIS A 174
GLY A 125
SER A 124
LEU A 383
HIS A 296
 None
 1.45A 2a58C-1yfmA:
undetectable
2a58D-1yfmA:
undetectable		 2a58C-1yfmA:
14.81
2a58D-1yfmA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AYL_B_FLPB2701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1yfm FUMARASE
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 185
ILE A 237
ALA A 241
SER A 243
LEU A 244
 None
 1.08A 2aylB-1yfmA:
undetectable		 2aylB-1yfmA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_B_9CRB502_1
(CYTOCHROME P450 2C8)		 1yfm FUMARASE
(Saccharomyces
cerevisiae) 		5 / 10 ILE A 398
ILE A 181
LEU A 306
ASN A 369
ILE A 372
 None
 1.19A 2nnhB-1yfmA:
undetectable		 2nnhB-1yfmA:
24.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FAL_C_REAC501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1yfm FUMARASE
(Saccharomyces
cerevisiae) 		5 / 10 ILE A 391
ALA A 176
ALA A 177
GLN A 180
LEU A  70
 None
 1.05A 3falC-1yfmA:
undetectable		 3falC-1yfmA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MTE_B_SAMB220_0
(16S RRNA METHYLASE)		 1yfm FUMARASE
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 254
GLY A 260
ASN A 262
ALA A 286
LEU A 293
 None
 0.86A 3mteB-1yfmA:
undetectable		 3mteB-1yfmA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_A_NIMA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1yfm FUMARASE
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 185
ILE A 237
ALA A 241
SER A 243
LEU A 244
 None
 1.07A 3n8xA-1yfmA:
undetectable		 3n8xA-1yfmA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Z_B_FLPB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1yfm FUMARASE
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 185
ILE A 237
ALA A 241
SER A 243
LEU A 244
 None
 1.00A 3n8zB-1yfmA:
undetectable		 3n8zB-1yfmA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZV_B_ECNB411_1
(FLAVOHEMOGLOBIN)		 1yfm FUMARASE
(Saccharomyces
cerevisiae) 		5 / 9 ILE A 175
ALA A 286
LEU A 250
LEU A  77
ALA A  73
 None
 1.00A 3ozvB-1yfmA:
undetectable		 3ozvB-1yfmA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_C_9PLC1_1
(CYTOCHROME P450 2A13)		 1yfm FUMARASE
(Saccharomyces
cerevisiae) 		4 / 7 PHE A 169
PHE A  74
ALA A  73
LEU A 395
 None
 0.95A 3t3sC-1yfmA:
0.1		 3t3sC-1yfmA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_A_SAMA401_0
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 1yfm FUMARASE
(Saccharomyces
cerevisiae) 		5 / 12 ALA A 256
LEU A 261
GLY A 254
ALA A  81
ASN A 262
 None
 1.30A 3tm4A-1yfmA:
undetectable		 3tm4A-1yfmA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_B_SAMB401_0
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 1yfm FUMARASE
(Saccharomyces
cerevisiae) 		5 / 12 ALA A 256
LEU A 261
GLY A 254
ALA A  81
ASN A 262
 None
 1.32A 3tm4B-1yfmA:
undetectable		 3tm4B-1yfmA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_B_NCTB501_1
(CYTOCHROME P450 2A13)		 1yfm FUMARASE
(Saccharomyces
cerevisiae) 		4 / 8 PHE A 169
PHE A  74
ALA A  73
LEU A 395
 None
 0.88A 4ejgB-1yfmA:
undetectable		 4ejgB-1yfmA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L8F_B_MTXB301_1
(GAMMA-GLUTAMYL
HYDROLASE)		 1yfm FUMARASE
(Saccharomyces
cerevisiae) 		5 / 11 GLY A 258
GLY A 254
GLY A 253
ALA A 256
GLN A 163
 None
 1.10A 4l8fB-1yfmA:
undetectable		 4l8fB-1yfmA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MA8_C_Z80C301_1
(MAJOR PRION PROTEIN)		 1yfm FUMARASE
(Saccharomyces
cerevisiae) 		4 / 5 GLY A  75
ILE A  99
LYS A  97
GLN A 100
 None
 1.06A 4ma8C-1yfmA:
undetectable		 4ma8C-1yfmA:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_A_STRA601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 1yfm FUMARASE
(Saccharomyces
cerevisiae) 		6 / 12 LEU A 394
ILE A 398
ILE A 401
ALA A 305
THR A 308
VAL A 365
 None
 1.25A 4nkxA-1yfmA:
undetectable		 4nkxA-1yfmA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVD_A_SAMA502_0
(D-MYCAROSE
3-C-METHYLTRANSFERAS
E)		 1yfm FUMARASE
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 237
GLY A 236
ALA A 310
HIS A 242
VAL A 240
 None
 1.11A 4rvdA-1yfmA:
undetectable		 4rvdA-1yfmA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_J_CHDJ103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 1yfm FUMARASE
(Saccharomyces
cerevisiae) 		5 / 11 ASN A 355
LEU A 358
LEU A 313
GLU A 414
LEU A 192
 None
 1.15A 4wg0J-1yfmA:
undetectable
4wg0K-1yfmA:
undetectable
4wg0L-1yfmA:
undetectable		 4wg0J-1yfmA:
2.52
4wg0K-1yfmA:
2.52
4wg0L-1yfmA:
2.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNW_A_RTZA602_1
(CYTOCHROME P450 2D6)		 1yfm FUMARASE
(Saccharomyces
cerevisiae) 		5 / 12 PHE A 115
GLY A 125
GLN A 121
VAL A 172
VAL A 135
 None
 1.07A 4wnwA-1yfmA:
0.2		 4wnwA-1yfmA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FEP_A_SAMA407_0
([FEFE] HYDROGENASE
MATURASE SUBUNIT
HYDE)		 1yfm FUMARASE
(Saccharomyces
cerevisiae) 		5 / 12 GLN A 232
SER A 312
GLY A 236
LEU A 309
ILE A 416
 None
 1.48A 5fepA-1yfmA:
undetectable		 5fepA-1yfmA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FES_A_SAMA408_0
([FEFE] HYDROGENASE
MATURASE SUBUNIT
HYDE)		 1yfm FUMARASE
(Saccharomyces
cerevisiae) 		5 / 12 GLN A 232
SER A 312
GLY A 236
LEU A 309
ILE A 416
 None
 1.49A 5fesA-1yfmA:
undetectable		 5fesA-1yfmA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWU_A_ACAA18_1
(WTFP-TAG,GP41)		 1yfm FUMARASE
(Saccharomyces
cerevisiae) 		5 / 12 ALA A 310
SER A 312
ASN A 191
LEU A 196
GLU A 197
 None
 1.27A 5nwuA-1yfmA:
undetectable		 5nwuA-1yfmA:
7.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH8_A_ACTA302_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 1yfm FUMARASE
(Saccharomyces
cerevisiae) 		3 / 3 CYH A 311
MET A 366
ASN A 369
 None
 1.12A 5qh8A-1yfmA:
0.0		 5qh8A-1yfmA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UAN_A_9CRA503_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1yfm FUMARASE
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 391
ALA A 176
ALA A 177
GLN A 180
LEU A  70
 None
 1.00A 5uanA-1yfmA:
undetectable		 5uanA-1yfmA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CI6_A_NBOA607_1
(SERUM ALBUMIN)		 1yfm FUMARASE
(Saccharomyces
cerevisiae) 		4 / 7 ASN A 194
ALA A 195
LYS A 199
GLU A 202
 None
 0.98A 6ci6A-1yfmA:
2.9		 6ci6A-1yfmA:
11.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FI4_B_DVAB8_0
(14-3-3 PROTEIN SIGMA
PRO-SEP-LEU-PRO-DVA)		 1yfm FUMARASE
(Saccharomyces
cerevisiae) 		4 / 5 SER A  87
VAL A  84
ASN A  85
PRO A 265
 None
 1.28A 6fi4A-1yfmA:
1.3
6fi4B-1yfmA:
undetectable		 6fi4A-1yfmA:
20.86
6fi4B-1yfmA:
1.43