SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1yfo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AKD_A_CAMA420_0
(CYTOCHROME P450CAM)		 1yfo RECEPTOR PROTEIN
TYROSINE PHOSPHATASE
ALPHA
(Mus
musculus) 		5 / 11 THR A 331
GLY A 436
THR A 440
VAL A 328
VAL A 330
 None
 1.28A 1akdA-1yfoA:
undetectable		 1akdA-1yfoA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_A_CHDA1502_0
(FERROCHELATASE)		 1yfo RECEPTOR PROTEIN
TYROSINE PHOSPHATASE
ALPHA
(Mus
musculus) 		4 / 8 ARG A 233
VAL A 404
GLY A 403
TRP A 399
 None
 1.01A 1hrkA-1yfoA:
undetectable		 1hrkA-1yfoA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M4I_A_KANA500_1
(AMINOGLYCOSIDE
2'-N-ACETYLTRANSFERA
SE)		 1yfo RECEPTOR PROTEIN
TYROSINE PHOSPHATASE
ALPHA
(Mus
musculus) 		4 / 8 ASP A 451
GLU A 297
GLY A 294
THR A 326
 None
 0.71A 1m4iA-1yfoA:
undetectable		 1m4iA-1yfoA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P93_D_DEXD4999_2
(GLUCOCORTICOID
RECEPTOR)		 1yfo RECEPTOR PROTEIN
TYROSINE PHOSPHATASE
ALPHA
(Mus
musculus) 		4 / 5 TRP A 399
MET A 411
LEU A 412
GLN A 487
 None
 1.28A 1p93D-1yfoA:
undetectable		 1p93D-1yfoA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TUF_B_AZ1B503_1
(DIAMINOPIMELATE
DECARBOXYLASE)		 1yfo RECEPTOR PROTEIN
TYROSINE PHOSPHATASE
ALPHA
(Mus
musculus) 		4 / 6 GLU A 234
ARG A 223
ARG A 224
TYR A 209
 None
 1.49A 1tufA-1yfoA:
undetectable
1tufB-1yfoA:
undetectable		 1tufA-1yfoA:
21.94
1tufB-1yfoA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z2B_C_VLBC800_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)		 1yfo RECEPTOR PROTEIN
TYROSINE PHOSPHATASE
ALPHA
(Mus
musculus) 		4 / 8 VAL A 461
THR A 442
TYR A 486
LEU A 489
 None
 1.01A 1z2bB-1yfoA:
undetectable		 1z2bB-1yfoA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4N_A_TPVA300_2
(PROTEASE)		 1yfo RECEPTOR PROTEIN
TYROSINE PHOSPHATASE
ALPHA
(Mus
musculus) 		5 / 8 LEU A 415
ASP A 447
ALA A 448
ILE A 485
ILE A 292
 None
 1.48A 2o4nB-1yfoA:
undetectable		 2o4nB-1yfoA:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLC_A_GLYA333_0
(CHOLOYLGLYCINE
HYDROLASE)		 1yfo RECEPTOR PROTEIN
TYROSINE PHOSPHATASE
ALPHA
(Mus
musculus) 		3 / 3 ASN A 260
ASN A 288
ARG A 472
 None
 0.65A 2rlcA-1yfoA:
undetectable		 2rlcA-1yfoA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_B_486B1_2
(GLUCOCORTICOID
RECEPTOR)		 1yfo RECEPTOR PROTEIN
TYROSINE PHOSPHATASE
ALPHA
(Mus
musculus) 		5 / 12 GLY A 438
GLY A 441
GLN A 477
VAL A 476
ILE A 485
 None
 1.10A 3h52B-1yfoA:
undetectable		 3h52B-1yfoA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MNO_A_DEXA784_2
(GLUCOCORTICOID
RECEPTOR)		 1yfo RECEPTOR PROTEIN
TYROSINE PHOSPHATASE
ALPHA
(Mus
musculus) 		4 / 6 MET A 449
LEU A 450
MET A 411
TYR A 486
 None
 1.50A 3mnoA-1yfoA:
undetectable		 3mnoA-1yfoA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MNP_A_DEXA784_2
(GLUCOCORTICOID
RECEPTOR)		 1yfo RECEPTOR PROTEIN
TYROSINE PHOSPHATASE
ALPHA
(Mus
musculus) 		4 / 6 MET A 449
LEU A 450
MET A 411
TYR A 486
 None
 1.49A 3mnpA-1yfoA:
0.0		 3mnpA-1yfoA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1yfo RECEPTOR PROTEIN
TYROSINE PHOSPHATASE
ALPHA
(Mus
musculus) 		4 / 8 ARG A 233
VAL A 404
GLY A 403
TRP A 399
 None
 0.87A 3w1wA-1yfoA:
undetectable		 3w1wA-1yfoA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM6_A_29EA603_1
(TRANSPORTER)		 1yfo RECEPTOR PROTEIN
TYROSINE PHOSPHATASE
ALPHA
(Mus
musculus) 		5 / 12 VAL A 431
ALA A 303
PHE A 414
PHE A 443
GLY A 441
 None
 1.17A 4mm6A-1yfoA:
undetectable		 4mm6A-1yfoA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_D_SAMD301_1
(UNCHARACTERIZED
PROTEIN)		 1yfo RECEPTOR PROTEIN
TYROSINE PHOSPHATASE
ALPHA
(Mus
musculus) 		3 / 3 ARG A 261
GLU A 338
TYR A 262
 None
 1.00A 4r29D-1yfoA:
undetectable		 4r29D-1yfoA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_A_DGXA1107_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 1yfo RECEPTOR PROTEIN
TYROSINE PHOSPHATASE
ALPHA
(Mus
musculus) 		4 / 4 ASN A 422
VAL A 328
THR A 324
ILE A 319
 None
 1.47A 4retA-1yfoA:
undetectable		 4retA-1yfoA:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_C_DGXC2005_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 1yfo RECEPTOR PROTEIN
TYROSINE PHOSPHATASE
ALPHA
(Mus
musculus) 		4 / 4 ASN A 422
VAL A 328
THR A 324
ILE A 319
 None
 1.47A 4retC-1yfoA:
2.0		 4retC-1yfoA:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CP4_A_CAMA422_0
(CYTOCHROME P450CAM)		 1yfo RECEPTOR PROTEIN
TYROSINE PHOSPHATASE
ALPHA
(Mus
musculus) 		5 / 9 THR A 331
GLY A 436
THR A 440
VAL A 328
VAL A 330
 None
 1.27A 5cp4A-1yfoA:
undetectable		 5cp4A-1yfoA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3C_A_AC2A301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 1yfo RECEPTOR PROTEIN
TYROSINE PHOSPHATASE
ALPHA
(Mus
musculus) 		5 / 9 GLY A 441
ALA A 448
VAL A 444
MET A 449
ILE A 292
 None
 1.42A 5i3cA-1yfoA:
undetectable		 5i3cA-1yfoA:
22.04