SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1yfy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IA0_B_TXLB502_1
(TUBULIN BETA CHAIN)		 1yfy 3-HYDROXYANTHRANILAT
E-3,4-DIOXYGENASE
(Cupriavidus
metallidurans) 		5 / 12 LEU A 139
ASP A  53
PHE A 150
PRO A  24
GLY A  26
 None
 1.32A 1ia0B-1yfyA:
undetectable		 1ia0B-1yfyA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_4
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1yfy 3-HYDROXYANTHRANILAT
E-3,4-DIOXYGENASE
(Cupriavidus
metallidurans) 		4 / 5 VAL A 132
CYH A 125
ALA A 127
CYH A 128
 None
FE  A 301 (-2.4A)
FE  A 301 ( 4.7A)
FE  A 301 (-2.2A)
 1.12A 1mz9D-1yfyA:
undetectable		 1mz9D-1yfyA:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TUB_B_TXLB501_1
(TUBULIN)		 1yfy 3-HYDROXYANTHRANILAT
E-3,4-DIOXYGENASE
(Cupriavidus
metallidurans) 		5 / 12 LEU A 139
ASP A  53
PHE A 150
PRO A  24
GLY A  26
 None
 1.32A 1tubB-1yfyA:
undetectable		 1tubB-1yfyA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_A_08JA1_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 1yfy 3-HYDROXYANTHRANILAT
E-3,4-DIOXYGENASE
(Cupriavidus
metallidurans) 		4 / 8 TRP A  31
VAL A  40
LEU A 107
LEU A  62
 None
 0.85A 3u5kA-1yfyA:
undetectable		 3u5kA-1yfyA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_B_08JB2_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 1yfy 3-HYDROXYANTHRANILAT
E-3,4-DIOXYGENASE
(Cupriavidus
metallidurans) 		4 / 7 TRP A  31
VAL A  40
LEU A 107
LEU A  62
 None
 0.85A 3u5kB-1yfyA:
undetectable		 3u5kB-1yfyA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_D_08JD4_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 1yfy 3-HYDROXYANTHRANILAT
E-3,4-DIOXYGENASE
(Cupriavidus
metallidurans) 		4 / 8 TRP A  31
VAL A  40
LEU A 107
LEU A  62
 None
 0.90A 3u5kD-1yfyA:
undetectable		 3u5kD-1yfyA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UVV_A_T3A501_2
(THYROID HORMONE
RECEPTOR ALPHA)		 1yfy 3-HYDROXYANTHRANILAT
E-3,4-DIOXYGENASE
(Cupriavidus
metallidurans) 		3 / 3 ARG A 111
MET A 117
ARG A 113
 None
 1.29A 3uvvA-1yfyA:
0.0		 3uvvA-1yfyA:
20.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HVR_A_SALA203_1
(3-HYDROXYANTHRANILAT
E 3,4-DIOXYGENASE)		 1yfy 3-HYDROXYANTHRANILAT
E-3,4-DIOXYGENASE
(Cupriavidus
metallidurans) 		7 / 7 HIS A  51
ASP A  53
GLU A  57
HIS A  95
PRO A  97
VAL A 108
GLU A 110
 FE  A 300 ( 3.1A)
None
FE  A 300 ( 2.2A)
FE  A 300 ( 3.2A)
3HA  A 401 (-3.7A)
None
3HA  A 401 ( 3.6A)
 0.55A 4hvrA-1yfyA:
26.4		 4hvrA-1yfyA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HVR_A_SALA203_1
(3-HYDROXYANTHRANILAT
E 3,4-DIOXYGENASE)		 1yfy 3-HYDROXYANTHRANILAT
E-3,4-DIOXYGENASE
(Cupriavidus
metallidurans) 		5 / 7 HIS A  95
ASP A  53
GLU A  57
VAL A 108
GLU A 110
 FE  A 300 ( 3.2A)
None
FE  A 300 ( 2.2A)
None
3HA  A 401 ( 3.6A)
 1.38A 4hvrA-1yfyA:
26.4		 4hvrA-1yfyA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LZR_A_LOCA201_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 1yfy 3-HYDROXYANTHRANILAT
E-3,4-DIOXYGENASE
(Cupriavidus
metallidurans) 		4 / 8 TRP A  31
VAL A  40
LEU A 107
LEU A  62
 None
 0.85A 4lzrA-1yfyA:
undetectable		 4lzrA-1yfyA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODI_D_ACTD202_0
(METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
D)		 1yfy 3-HYDROXYANTHRANILAT
E-3,4-DIOXYGENASE
(Cupriavidus
metallidurans) 		3 / 3 HIS A  17
GLU A  16
TRP A  13
 None
 0.87A 5odiD-1yfyA:
undetectable		 5odiD-1yfyA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODQ_D_ACTD202_0
(METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
D)		 1yfy 3-HYDROXYANTHRANILAT
E-3,4-DIOXYGENASE
(Cupriavidus
metallidurans) 		3 / 3 HIS A  17
GLU A  16
TRP A  13
 None
 0.86A 5odqD-1yfyA:
undetectable		 5odqD-1yfyA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODR_D_ACTD202_0
(METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
D)		 1yfy 3-HYDROXYANTHRANILAT
E-3,4-DIOXYGENASE
(Cupriavidus
metallidurans) 		3 / 3 HIS A  17
GLU A  16
TRP A  13
 None
 0.81A 5odrD-1yfyA:
undetectable		 5odrD-1yfyA:
18.79