SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1yg2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IB4_A_ERMA2001_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 1yg2 GENE ACTIVATOR APHA
(Vibrio
cholerae) 		5 / 12 LEU A   3
VAL A  40
MET A  47
ALA A  78
VAL A  10
 None
 1.19A 4ib4A-1yg2A:
4.8		 4ib4A-1yg2A:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NC3_A_ERMA1202_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 1yg2 GENE ACTIVATOR APHA
(Vibrio
cholerae) 		5 / 12 LEU A   3
VAL A  40
MET A  47
ALA A  78
VAL A  10
 None
 1.21A 4nc3A-1yg2A:
3.2		 4nc3A-1yg2A:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTB_A_SAMA501_1
(HYDG PROTEIN)		 1yg2 GENE ACTIVATOR APHA
(Vibrio
cholerae) 		3 / 3 GLU A 133
ARG A 151
GLN A 162
 None
 0.78A 4rtbA-1yg2A:
undetectable		 4rtbA-1yg2A:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L6E_B_ACTB401_0
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT
N6-ADENOSINE-METHYLT
RANSFERASE SUBUNIT
METTL14)		 1yg2 GENE ACTIVATOR APHA
(Vibrio
cholerae) 		4 / 6 ARG A 151
LEU A 154
ARG A 156
ARG A 155
 None
 1.27A 5l6eA-1yg2A:
undetectable
5l6eB-1yg2A:
undetectable		 5l6eA-1yg2A:
21.65
5l6eB-1yg2A:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MWY_A_YNUA1101_0
(MINERALOCORTICOID
RECEPTOR)		 1yg2 GENE ACTIVATOR APHA
(Vibrio
cholerae) 		5 / 12 LEU A 172
LEU A 175
ASN A 176
ALA A 179
SER A 107
 None
 0.95A 5mwyA-1yg2A:
undetectable		 5mwyA-1yg2A:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 1yg2 GENE ACTIVATOR APHA
(Vibrio
cholerae) 		3 / 3 ARG A 112
PHE A  96
LEU A 172
 None
 0.94A 5x1bC-1yg2A:
3.8		 5x1bC-1yg2A:
22.01