SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1yg8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LHV_A_NOGA301_1
(SEX HORMONE-BINDING
GLOBULIN)		 1yg8 ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT
(Escherichia
coli) 		4 / 8 ASP A  37
MET A  98
MET A  39
LEU A  31
 None
 1.02A 1lhvA-1yg8A:
undetectable		 1lhvA-1yg8A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_B_STRB2001_2
(MINERALOCORTICOID
RECEPTOR)		 1yg8 ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT
(Escherichia
coli) 		3 / 3 LEU A 174
LEU A 103
MET A 153
 None
 0.60A 1ya3B-1yg8A:
undetectable		 1ya3B-1yg8A:
24.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_A_BEZA11_0
(CES1 PROTEIN)		 1yg8 ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT
(Escherichia
coli) 		4 / 4 LEU A 102
SER A  75
LEU A  61
LEU A  31
 None
 1.03A 1yajA-1yg8A:
undetectable		 1yajA-1yg8A:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		 1yg8 ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT
(Escherichia
coli) 		5 / 12 ARG A 118
ILE A  63
LEU A 103
ALA A  96
ALA A  95
 None
 1.01A 2oc8A-1yg8A:
undetectable		 2oc8A-1yg8A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_A_GJZA506_1
(CHOLESTEROL
24-HYDROXYLASE)		 1yg8 ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT
(Escherichia
coli) 		4 / 6 LEU A 102
ILE A  43
ALA A  40
THR A  79
 None
 0.79A 3mdrA-1yg8A:
undetectable		 3mdrA-1yg8A:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CR1_A_T44A201_1
(TRANSTHYRETIN)		 1yg8 ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT
(Escherichia
coli) 		4 / 5 LEU A 152
ALA A 105
LEU A 155
VAL A  87
 None
 1.17A 5cr1A-1yg8A:
undetectable		 5cr1A-1yg8A:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6APH_A_ADNA501_2
(ADENOSYLHOMOCYSTEINA
SE)		 1yg8 ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT
(Escherichia
coli) 		4 / 5 GLN A  81
THR A  79
THR A  71
LEU A 102
 None
 1.23A 6aphA-1yg8A:
undetectable		 6aphA-1yg8A:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3M_A_ADNA502_2
(-)		 1yg8 ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT
(Escherichia
coli) 		4 / 4 GLN A  81
THR A  79
THR A  71
LEU A 102
 None
 1.21A 6f3mA-1yg8A:
undetectable		 6f3mA-1yg8A:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3M_C_ADNC502_2
(-)		 1yg8 ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT
(Escherichia
coli) 		4 / 4 GLN A  81
THR A  79
THR A  71
LEU A 102
 None
 1.20A 6f3mC-1yg8A:
undetectable		 6f3mC-1yg8A:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_B_ADNB501_2
(-)		 1yg8 ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT
(Escherichia
coli) 		4 / 5 GLN A  81
THR A  79
THR A  71
LEU A 102
 None
 1.26A 6gbnB-1yg8A:
undetectable		 6gbnB-1yg8A:
18.73