SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ygg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FAP_A_RAPA108_2
(FK506-BINDING
PROTEIN
FRAP)		 1ygg PHOSPHOENOLPYRUVATE
CARBOXYKINASE
(Actinobacillus
succinogenes) 		4 / 8 LEU A 384
PHE A 247
GLY A 248
TYR A 421
 None
 0.94A 1fapB-1yggA:
undetectable		 1fapB-1yggA:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A15_A_NCAA1001_0
(HYPOTHETICAL PROTEIN
RV0760C)		 1ygg PHOSPHOENOLPYRUVATE
CARBOXYKINASE
(Actinobacillus
succinogenes) 		5 / 11 VAL A 120
ILE A  23
LEU A 118
LEU A  15
LEU A  17
 None
 1.25A 2a15A-1yggA:
undetectable		 2a15A-1yggA:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXG_A_IBPA2002_1
(SERUM ALBUMIN)		 1ygg PHOSPHOENOLPYRUVATE
CARBOXYKINASE
(Actinobacillus
succinogenes) 		4 / 8 ALA A 192
GLU A 197
LEU A 108
VAL A 109
 None
 0.75A 2bxgA-1yggA:
undetectable		 2bxgA-1yggA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F9W_A_PAUA6002_0
(PANTOTHENATE KINASE)		 1ygg PHOSPHOENOLPYRUVATE
CARBOXYKINASE
(Actinobacillus
succinogenes) 		4 / 8 ARG A  65
THR A 205
GLY A 209
ILE A 202
 None
 0.75A 2f9wA-1yggA:
undetectable
2f9wB-1yggA:
undetectable		 2f9wA-1yggA:
21.28
2f9wB-1yggA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LH6_A_NIOA155_1
(LEGHEMOGLOBIN A
(NICOTINATE MET))		 1ygg PHOSPHOENOLPYRUVATE
CARBOXYKINASE
(Actinobacillus
succinogenes) 		4 / 5 PHE A 478
PHE A 517
PHE A 405
VAL A 367
 None
 1.22A 2lh6A-1yggA:
undetectable		 2lh6A-1yggA:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_2
(PROTEASE RETROPEPSIN)		 1ygg PHOSPHOENOLPYRUVATE
CARBOXYKINASE
(Actinobacillus
succinogenes) 		3 / 3 ARG A 333
ASN A 296
THR A 255
 None
None
SO4  A4121 (-3.7A)
 0.80A 2q63A-1yggA:
undetectable		 2q63A-1yggA:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RK8_A_PPFA3969_1
(PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP])		 1ygg PHOSPHOENOLPYRUVATE
CARBOXYKINASE
(Actinobacillus
succinogenes) 		6 / 8 ARG A  65
LYS A 212
LYS A 213
HIS A 232
ASP A 269
ARG A 333
 None
 0.96A 2rk8A-1yggA:
27.7		 2rk8A-1yggA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RK8_B_PPFB3969_1
(PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP])		 1ygg PHOSPHOENOLPYRUVATE
CARBOXYKINASE
(Actinobacillus
succinogenes) 		6 / 7 ARG A  65
LYS A 212
LYS A 213
HIS A 232
ASP A 269
ARG A 333
 None
 0.85A 2rk8B-1yggA:
28.3		 2rk8B-1yggA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VQ5_B_LDPB1197_1
(S-NORCOCLAURINE
SYNTHASE)		 1ygg PHOSPHOENOLPYRUVATE
CARBOXYKINASE
(Actinobacillus
succinogenes) 		5 / 7 LEU A 368
LEU A 513
PHE A 478
LEU A 438
TYR A 381
 None
 1.42A 2vq5B-1yggA:
undetectable		 2vq5B-1yggA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CR4_X_PNTX101_0
(PROTEIN S100-B)		 1ygg PHOSPHOENOLPYRUVATE
CARBOXYKINASE
(Actinobacillus
succinogenes) 		3 / 3 CYH A 408
HIS A 232
PHE A 247
 None
 1.18A 3cr4X-1yggA:
0.0		 3cr4X-1yggA:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_A_V2HA602_0
(CYTOCHROME P450 2R1)		 1ygg PHOSPHOENOLPYRUVATE
CARBOXYKINASE
(Actinobacillus
succinogenes) 		5 / 12 PHE A 193
VAL A 169
TYR A  71
GLU A 210
MET A 137
 None
 1.19A 3dl9A-1yggA:
undetectable		 3dl9A-1yggA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E9R_A_ACTA700_0
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 1ygg PHOSPHOENOLPYRUVATE
CARBOXYKINASE
(Actinobacillus
succinogenes) 		4 / 6 GLY A  64
GLU A 311
GLY A 209
ASN A 331
 None
 1.06A 3e9rA-1yggA:
undetectable		 3e9rA-1yggA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E9R_C_ACTC700_0
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 1ygg PHOSPHOENOLPYRUVATE
CARBOXYKINASE
(Actinobacillus
succinogenes) 		4 / 6 GLY A  64
GLU A 311
GLY A 209
ASN A 331
 None
 1.08A 3e9rC-1yggA:
undetectable		 3e9rC-1yggA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9F_F_LFXF0_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 1ygg PHOSPHOENOLPYRUVATE
CARBOXYKINASE
(Actinobacillus
succinogenes) 		4 / 5 SER A 230
ARG A  65
GLY A 214
GLU A 210
 None
 1.30A 3k9fA-1yggA:
undetectable
3k9fB-1yggA:
undetectable
3k9fC-1yggA:
undetectable		 3k9fA-1yggA:
22.90
3k9fB-1yggA:
22.90
3k9fC-1yggA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_T_TFPT202_1
(PROTEIN S100-A4)		 1ygg PHOSPHOENOLPYRUVATE
CARBOXYKINASE
(Actinobacillus
succinogenes) 		5 / 11 ASP A  93
PHE A 193
GLU A 210
ASP A  69
ILE A 202
 None
 1.33A 3ko0Q-1yggA:
0.0
3ko0R-1yggA:
0.0
3ko0S-1yggA:
0.0
3ko0T-1yggA:
undetectable		 3ko0Q-1yggA:
10.18
3ko0R-1yggA:
10.18
3ko0S-1yggA:
10.18
3ko0T-1yggA:
10.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MEG_A_T27A561_1
(P66 REVERSE
TRANSCRIPTASE)		 1ygg PHOSPHOENOLPYRUVATE
CARBOXYKINASE
(Actinobacillus
succinogenes) 		5 / 12 PRO A 538
LEU A 480
TYR A 381
PHE A 359
LEU A 438
 None
 1.35A 3megA-1yggA:
0.0		 3megA-1yggA:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX5_B_MIYB1103_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 1ygg PHOSPHOENOLPYRUVATE
CARBOXYKINASE
(Actinobacillus
succinogenes) 		5 / 12 SER A 217
GLN A 144
PHE A  62
ILE A 202
ALA A 173
 None
 1.06A 4dx5B-1yggA:
undetectable		 4dx5B-1yggA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JEC_B_478B401_3
(HIV-1 PROTEASE)		 1ygg PHOSPHOENOLPYRUVATE
CARBOXYKINASE
(Actinobacillus
succinogenes) 		3 / 3 ASP A  69
LEU A 105
VAL A 169
 None
 0.69A 4jecB-1yggA:
undetectable		 4jecB-1yggA:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMC_A_29JA604_1
(TRANSPORTER)		 1ygg PHOSPHOENOLPYRUVATE
CARBOXYKINASE
(Actinobacillus
succinogenes) 		4 / 7 PHE A 517
LEU A 368
ASP A 363
THR A 252
 None
None
None
SO4  A4121 (-4.1A)
 1.07A 4mmcA-1yggA:
0.0		 4mmcA-1yggA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_A_AERA601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 1ygg PHOSPHOENOLPYRUVATE
CARBOXYKINASE
(Actinobacillus
succinogenes) 		5 / 12 LEU A 257
ARG A 456
GLY A 457
VAL A 439
VAL A 371
 None
 0.93A 4nkvA-1yggA:
undetectable		 4nkvA-1yggA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_C_AERC601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 1ygg PHOSPHOENOLPYRUVATE
CARBOXYKINASE
(Actinobacillus
succinogenes) 		5 / 12 LEU A 257
ARG A 456
GLY A 457
VAL A 439
VAL A 371
 None
 1.01A 4nkvC-1yggA:
undetectable		 4nkvC-1yggA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_A_SAMA602_1
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 1ygg PHOSPHOENOLPYRUVATE
CARBOXYKINASE
(Actinobacillus
succinogenes) 		3 / 3 ASP A  93
ASN A 186
SER A  86
 None
 0.81A 4obwA-1yggA:
undetectable		 4obwA-1yggA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R87_E_SPME202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 1ygg PHOSPHOENOLPYRUVATE
CARBOXYKINASE
(Actinobacillus
succinogenes) 		4 / 5 GLU A  35
GLU A  36
GLU A  34
GLU A  30
 None
 1.45A 4r87E-1yggA:
0.0		 4r87E-1yggA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0Y_A_FOLA201_1
(CONSERVED
HYPOTHETICAL
MEMBRANE PROTEIN)		 1ygg PHOSPHOENOLPYRUVATE
CARBOXYKINASE
(Actinobacillus
succinogenes) 		3 / 3 ARG A 136
LYS A   7
GLU A  11
 None
 0.82A 5d0yA-1yggA:
undetectable		 5d0yA-1yggA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZF_E_AZ1E2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
6J9-ZEU-DAR-ACA-DAR-
NH2)		 1ygg PHOSPHOENOLPYRUVATE
CARBOXYKINASE
(Actinobacillus
succinogenes) 		4 / 7 GLY A 248
GLY A 386
SER A 385
PHE A 405
 None
 0.88A 5izfA-1yggA:
undetectable		 5izfA-1yggA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_A_ACTA612_0
(NADH DEHYDROGENASE,
PUTATIVE)		 1ygg PHOSPHOENOLPYRUVATE
CARBOXYKINASE
(Actinobacillus
succinogenes) 		3 / 3 LYS A 239
ASP A 240
ARG A 263
 None
 1.00A 5jwaA-1yggA:
undetectable
5jwaH-1yggA:
undetectable		 5jwaA-1yggA:
24.80
5jwaH-1yggA:
24.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUR_B_PFLB407_1
(PROTON-GATED ION
CHANNEL)		 1ygg PHOSPHOENOLPYRUVATE
CARBOXYKINASE
(Actinobacillus
succinogenes) 		4 / 7 ILE A 459
ILE A 458
THR A 441
ILE A 450
 None
 0.91A 5murB-1yggA:
undetectable		 5murB-1yggA:
10.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_A_PFLA511_1
(PROTON-GATED ION
CHANNEL)		 1ygg PHOSPHOENOLPYRUVATE
CARBOXYKINASE
(Actinobacillus
succinogenes) 		4 / 8 PRO A 483
ILE A 458
ALA A 461
ILE A 462
 None
 0.71A 5mvmA-1yggA:
undetectable
5mvmB-1yggA:
undetectable		 5mvmA-1yggA:
10.69
5mvmB-1yggA:
10.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_A_SAMA902_1
(MRNA CAPPING ENZYME
P5)		 1ygg PHOSPHOENOLPYRUVATE
CARBOXYKINASE
(Actinobacillus
succinogenes) 		3 / 3 TYR A  71
ASP A  93
ASP A  69
 None
 0.57A 5x6yA-1yggA:
undetectable		 5x6yA-1yggA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BP4_A_SAMA505_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC)		 1ygg PHOSPHOENOLPYRUVATE
CARBOXYKINASE
(Actinobacillus
succinogenes) 		3 / 3 ILE A 341
ASN A 280
CYH A 233
 None
 0.90A 6bp4A-1yggA:
undetectable		 6bp4A-1yggA:
19.50