SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ygh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_C_EAAC223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 1ygh PROTEIN
(TRANSCRIPTIONAL
ACTIVATOR GCN5)
(Saccharomyces
cerevisiae) 		4 / 8 GLY A 160
LEU A 120
VAL A 105
PHE A 102
 None
 1.03A 1gsfC-1yghA:
undetectable		 1gsfC-1yghA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_A_SAMA301_1
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 1ygh PROTEIN
(TRANSCRIPTIONAL
ACTIVATOR GCN5)
(Saccharomyces
cerevisiae) 		3 / 3 TYR A 141
THR A 118
GLU A 134
 None
 0.70A 4df3A-1yghA:
undetectable		 4df3A-1yghA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_B_SAMB301_1
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 1ygh PROTEIN
(TRANSCRIPTIONAL
ACTIVATOR GCN5)
(Saccharomyces
cerevisiae) 		3 / 3 TYR A 141
THR A 118
GLU A 134
 None
 0.73A 4df3B-1yghA:
undetectable		 4df3B-1yghA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X20_D_LOCD502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 1ygh PROTEIN
(TRANSCRIPTIONAL
ACTIVATOR GCN5)
(Saccharomyces
cerevisiae) 		3 / 3 SER A 147
ALA A 149
VAL A 150
 None
 0.67A 4x20C-1yghA:
undetectable		 4x20C-1yghA:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_A_JMSA602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1ygh PROTEIN
(TRANSCRIPTIONAL
ACTIVATOR GCN5)
(Saccharomyces
cerevisiae) 		3 / 3 VAL A 157
SER A 147
MET A 193
 None
 0.77A 5ikqA-1yghA:
undetectable		 5ikqA-1yghA:
14.07