SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ygu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q8J_A_C2FA801_0
(5-METHYLTETRAHYDROFO
LATE S-HOMOCYSTEINE
METHYLTRANSFERASE)		 1ygu LEUKOCYTE COMMON
ANTIGEN
(Homo
sapiens) 		5 / 12 ASN A 735
ASP A 705
GLY A 702
SER A 829
ARG A 834
 None
 1.34A 1q8jA-1yguA:
undetectable		 1q8jA-1yguA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_C_DESC500_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 1ygu LEUKOCYTE COMMON
ANTIGEN
(Homo
sapiens) 		5 / 12 LEU A1157
LEU A1160
ALA A1164
LEU A 897
VAL A 895
 None
 0.86A 1s9pC-1yguA:
undetectable		 1s9pC-1yguA:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_D_DESD600_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 1ygu LEUKOCYTE COMMON
ANTIGEN
(Homo
sapiens) 		5 / 12 LEU A1157
LEU A1160
ALA A1164
LEU A 897
VAL A 895
 None
 0.80A 1s9pD-1yguA:
undetectable		 1s9pD-1yguA:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		 1ygu LEUKOCYTE COMMON
ANTIGEN
(Homo
sapiens) 		5 / 12 VAL A1175
LEU A1157
LEU A1160
LEU A1140
LEU A1179
 None
 1.36A 1ya4B-1yguA:
undetectable		 1ya4B-1yguA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A7Q_A_CFBA328_2
(DEOXYCYTIDINE KINASE)		 1ygu LEUKOCYTE COMMON
ANTIGEN
(Homo
sapiens) 		4 / 4 ILE A 612
ASP A 855
LEU A 848
ARG A 619
 None
 1.39A 2a7qA-1yguA:
undetectable		 2a7qA-1yguA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_A_CHDA702_0
(FERROCHELATASE)		 1ygu LEUKOCYTE COMMON
ANTIGEN
(Homo
sapiens) 		4 / 7 MET A1115
ARG A1077
PRO A1106
TRP A1100
 None
 1.34A 2hrcA-1yguA:
undetectable		 2hrcA-1yguA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LBD_A_REAA500_1
(RETINOIC ACID
RECEPTOR GAMMA)		 1ygu LEUKOCYTE COMMON
ANTIGEN
(Homo
sapiens) 		5 / 12 PHE A 639
ARG A 867
PHE A 642
GLY A 858
LEU A 602
 None
 1.27A 2lbdA-1yguA:
undetectable		 2lbdA-1yguA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_B_CHDB502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1ygu LEUKOCYTE COMMON
ANTIGEN
(Homo
sapiens) 		4 / 7 MET A1115
ARG A1077
PRO A1106
TRP A1100
 None
 1.23A 2pnjB-1yguA:
undetectable		 2pnjB-1yguA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLC_A_GLYA333_0
(CHOLOYLGLYCINE
HYDROLASE)		 1ygu LEUKOCYTE COMMON
ANTIGEN
(Homo
sapiens) 		3 / 3 ASN A 656
ASN A 684
ARG A 867
 None
 0.66A 2rlcA-1yguA:
undetectable		 2rlcA-1yguA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLC_A_GLYA333_0
(CHOLOYLGLYCINE
HYDROLASE)		 1ygu LEUKOCYTE COMMON
ANTIGEN
(Homo
sapiens) 		3 / 3 ASN A 947
ASN A 994
ARG A1183
 None
 0.77A 2rlcA-1yguA:
undetectable		 2rlcA-1yguA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZM_A_SAMA401_1
(UNCHARACTERIZED
PROTEIN MJ0883)		 1ygu LEUKOCYTE COMMON
ANTIGEN
(Homo
sapiens) 		3 / 3 ARG A 959
ASP A1020
ASN A 943
 None
 0.83A 2zzmA-1yguA:
undetectable		 2zzmA-1yguA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_A_CHDA2_0
(FERROCHELATASE)		 1ygu LEUKOCYTE COMMON
ANTIGEN
(Homo
sapiens) 		4 / 6 MET A1115
ARG A1077
PRO A1106
TRP A1100
 None
 1.30A 3aqiA-1yguA:
undetectable		 3aqiA-1yguA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BEX_A_PAUA248_0
(TYPE III
PANTOTHENATE KINASE)		 1ygu LEUKOCYTE COMMON
ANTIGEN
(Homo
sapiens) 		5 / 10 ASN A 994
VAL A 952
GLY A1185
ASP A1146
THR A1151
 None
 1.27A 3bexA-1yguA:
undetectable
3bexB-1yguA:
undetectable		 3bexA-1yguA:
17.62
3bexB-1yguA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BEX_B_PAUB248_0
(TYPE III
PANTOTHENATE KINASE)		 1ygu LEUKOCYTE COMMON
ANTIGEN
(Homo
sapiens) 		5 / 9 ASN A 994
VAL A 952
GLY A1185
ASP A1146
THR A1151
 None
 1.28A 3bexA-1yguA:
0.0
3bexB-1yguA:
0.0		 3bexA-1yguA:
17.62
3bexB-1yguA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BEX_C_PAUC248_0
(TYPE III
PANTOTHENATE KINASE)		 1ygu LEUKOCYTE COMMON
ANTIGEN
(Homo
sapiens) 		5 / 11 ASN A 994
VAL A 952
GLY A1185
ASP A1146
THR A1151
 None
 1.28A 3bexC-1yguA:
undetectable
3bexD-1yguA:
undetectable		 3bexC-1yguA:
17.62
3bexD-1yguA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BEX_D_PAUD248_0
(TYPE III
PANTOTHENATE KINASE)		 1ygu LEUKOCYTE COMMON
ANTIGEN
(Homo
sapiens) 		5 / 10 ASN A 994
VAL A 952
GLY A1185
ASP A1146
THR A1151
 None
 1.28A 3bexC-1yguA:
undetectable
3bexD-1yguA:
undetectable		 3bexC-1yguA:
17.62
3bexD-1yguA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BEX_E_PAUE248_0
(TYPE III
PANTOTHENATE KINASE)		 1ygu LEUKOCYTE COMMON
ANTIGEN
(Homo
sapiens) 		5 / 10 ASN A 994
VAL A 952
GLY A1185
ASP A1146
THR A1151
 None
 1.28A 3bexE-1yguA:
undetectable
3bexF-1yguA:
undetectable		 3bexE-1yguA:
17.62
3bexF-1yguA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BEX_F_PAUF248_0
(TYPE III
PANTOTHENATE KINASE)		 1ygu LEUKOCYTE COMMON
ANTIGEN
(Homo
sapiens) 		5 / 11 ASN A 994
VAL A 952
GLY A1185
ASP A1146
THR A1151
 None
 1.28A 3bexE-1yguA:
undetectable
3bexF-1yguA:
undetectable		 3bexE-1yguA:
17.62
3bexF-1yguA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_A_PAUA248_0
(TYPE III
PANTOTHENATE KINASE)		 1ygu LEUKOCYTE COMMON
ANTIGEN
(Homo
sapiens) 		5 / 11 ASN A 994
VAL A 952
GLY A1185
ASP A1146
THR A1151
 None
 1.33A 3bf1A-1yguA:
undetectable
3bf1B-1yguA:
undetectable		 3bf1A-1yguA:
17.62
3bf1B-1yguA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_C_PAUC248_0
(TYPE III
PANTOTHENATE KINASE)		 1ygu LEUKOCYTE COMMON
ANTIGEN
(Homo
sapiens) 		5 / 11 ASN A 994
VAL A 952
GLY A1185
ASP A1146
THR A1151
 None
 1.28A 3bf1C-1yguA:
undetectable
3bf1D-1yguA:
undetectable		 3bf1C-1yguA:
17.62
3bf1D-1yguA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_D_PAUD248_0
(TYPE III
PANTOTHENATE KINASE)		 1ygu LEUKOCYTE COMMON
ANTIGEN
(Homo
sapiens) 		5 / 11 ASN A 994
VAL A 952
GLY A1185
ASP A1146
THR A1151
 None
 1.29A 3bf1C-1yguA:
undetectable
3bf1D-1yguA:
undetectable		 3bf1C-1yguA:
17.62
3bf1D-1yguA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_E_PAUE248_0
(TYPE III
PANTOTHENATE KINASE)		 1ygu LEUKOCYTE COMMON
ANTIGEN
(Homo
sapiens) 		5 / 11 ASN A 994
VAL A 952
GLY A1185
ASP A1146
THR A1151
 None
 1.27A 3bf1E-1yguA:
undetectable
3bf1F-1yguA:
undetectable		 3bf1E-1yguA:
17.62
3bf1F-1yguA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_F_PAUF248_0
(TYPE III
PANTOTHENATE KINASE)		 1ygu LEUKOCYTE COMMON
ANTIGEN
(Homo
sapiens) 		5 / 11 ASN A 994
VAL A 952
GLY A1185
ASP A1146
THR A1151
 None
 1.28A 3bf1E-1yguA:
undetectable
3bf1F-1yguA:
undetectable		 3bf1E-1yguA:
17.62
3bf1F-1yguA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_A_H3PA552_1
(GLUTAMATE
DEHYDROGENASE)		 1ygu LEUKOCYTE COMMON
ANTIGEN
(Homo
sapiens) 		4 / 6 ILE A 824
TYR A 687
ILE A 715
HIS A 788
 None
 1.17A 3eteA-1yguA:
undetectable
3eteE-1yguA:
undetectable		 3eteA-1yguA:
23.60
3eteE-1yguA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_C_H3PC554_1
(GLUTAMATE
DEHYDROGENASE)		 1ygu LEUKOCYTE COMMON
ANTIGEN
(Homo
sapiens) 		4 / 5 ILE A 824
TYR A 687
ILE A 715
HIS A 788
 None
 1.18A 3eteB-1yguA:
undetectable
3eteC-1yguA:
undetectable		 3eteB-1yguA:
23.60
3eteC-1yguA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_F_H3PF552_1
(GLUTAMATE
DEHYDROGENASE)		 1ygu LEUKOCYTE COMMON
ANTIGEN
(Homo
sapiens) 		4 / 7 ILE A 715
HIS A 788
ILE A 824
TYR A 687
 None
 1.18A 3eteD-1yguA:
undetectable
3eteF-1yguA:
undetectable		 3eteD-1yguA:
23.60
3eteF-1yguA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LB3_A_4CHA191_0
(DEHALOPEROXIDASE A)		 1ygu LEUKOCYTE COMMON
ANTIGEN
(Homo
sapiens) 		4 / 6 PHE A 816
HIS A 788
THR A 787
VAL A 722
 None
 0.88A 3lb3A-1yguA:
undetectable		 3lb3A-1yguA:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LB3_B_4CHB192_0
(DEHALOPEROXIDASE A)		 1ygu LEUKOCYTE COMMON
ANTIGEN
(Homo
sapiens) 		4 / 6 PHE A 816
HIS A 788
THR A 787
VAL A 722
 None
 0.78A 3lb3B-1yguA:
0.0		 3lb3B-1yguA:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MEC_A_65BA561_0
(P66 REVERSE
TRANSCRIPTASE)		 1ygu LEUKOCYTE COMMON
ANTIGEN
(Homo
sapiens) 		5 / 12 LEU A 879
VAL A 871
TYR A 838
GLY A 833
PRO A 795
 None
 1.25A 3mecA-1yguA:
undetectable		 3mecA-1yguA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PFG_A_SAMA264_1
(N-METHYLTRANSFERASE)		 1ygu LEUKOCYTE COMMON
ANTIGEN
(Homo
sapiens) 		3 / 3 TYR A 697
TYR A 859
GLU A 693
 None
 0.85A 3pfgA-1yguA:
undetectable		 3pfgA-1yguA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q5P_A_TACA7101_1
(MULTIDRUG-EFFLUX
TRANSPORTER 1
REGULATOR)		 1ygu LEUKOCYTE COMMON
ANTIGEN
(Homo
sapiens) 		5 / 12 ASN A 947
TYR A 992
ILE A1142
PHE A1021
ILE A 993
 None
 1.40A 3q5pA-1yguA:
undetectable		 3q5pA-1yguA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q5R_A_KANA2002_1
(MULTIDRUG-EFFLUX
TRANSPORTER 1
REGULATOR)		 1ygu LEUKOCYTE COMMON
ANTIGEN
(Homo
sapiens) 		5 / 11 ASN A 947
TYR A 992
ILE A1142
PHE A1021
ILE A 993
 None
 1.40A 3q5rA-1yguA:
0.0		 3q5rA-1yguA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQW_C_ACHC323_0
(ELIC PENTAMERIC
LIGAND GATED ION
CHANNEL FROM ERWINIA
CHRYSANTHEMI)		 1ygu LEUKOCYTE COMMON
ANTIGEN
(Homo
sapiens) 		4 / 8 PHE A 791
TYR A 767
GLU A1167
LEU A 805
 None
 1.06A 3rqwC-1yguA:
undetectable
3rqwD-1yguA:
undetectable		 3rqwC-1yguA:
20.29
3rqwD-1yguA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQW_C_ACHC323_0
(ELIC PENTAMERIC
LIGAND GATED ION
CHANNEL FROM ERWINIA
CHRYSANTHEMI)		 1ygu LEUKOCYTE COMMON
ANTIGEN
(Homo
sapiens) 		4 / 8 TYR A 767
GLU A1167
GLU A 894
LEU A 805
 None
 0.96A 3rqwC-1yguA:
undetectable
3rqwD-1yguA:
undetectable		 3rqwC-1yguA:
20.29
3rqwD-1yguA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQW_J_ACHJ323_0
(ELIC PENTAMERIC
LIGAND GATED ION
CHANNEL FROM ERWINIA
CHRYSANTHEMI)		 1ygu LEUKOCYTE COMMON
ANTIGEN
(Homo
sapiens) 		5 / 8 GLU A1167
GLU A 894
LEU A 805
PHE A 791
TYR A 767
 None
 1.09A 3rqwF-1yguA:
undetectable
3rqwJ-1yguA:
undetectable		 3rqwF-1yguA:
20.29
3rqwJ-1yguA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3V_A_TOPA193_1
(DIHYDROFOLATE
REDUCTASE)		 1ygu LEUKOCYTE COMMON
ANTIGEN
(Homo
sapiens) 		4 / 5 LEU A1039
ILE A1018
PRO A1013
PHE A1021
 None
 1.24A 3s3vA-1yguA:
undetectable		 3s3vA-1yguA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TNE_A_RITA401_2
(SECRETED ASPARTIC
PROTEASE)		 1ygu LEUKOCYTE COMMON
ANTIGEN
(Homo
sapiens) 		4 / 6 PRO A1106
SER A1071
TYR A1074
THR A1098
 None
 1.03A 3tneA-1yguA:
undetectable		 3tneA-1yguA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_B_AZMB229_1
(CARBONIC ANHYDRASE)		 1ygu LEUKOCYTE COMMON
ANTIGEN
(Homo
sapiens) 		3 / 3 GLN A1094
PHE A1079
TYR A1050
 None
 1.00A 3ucjA-1yguA:
undetectable		 3ucjA-1yguA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_A_ZPCA1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1ygu LEUKOCYTE COMMON
ANTIGEN
(Homo
sapiens) 		4 / 7 GLU A 894
GLU A1167
TYR A 767
VAL A 722
 None
 0.75A 4a97A-1yguA:
undetectable		 4a97A-1yguA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_D_ZPCD1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1ygu LEUKOCYTE COMMON
ANTIGEN
(Homo
sapiens) 		4 / 7 GLU A 894
GLU A1167
TYR A 767
VAL A 722
 None
 0.87A 4a97D-1yguA:
undetectable		 4a97D-1yguA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_H_ZPCH1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1ygu LEUKOCYTE COMMON
ANTIGEN
(Homo
sapiens) 		4 / 7 GLU A 894
GLU A1167
TYR A 767
VAL A 722
 None
 0.80A 4a97H-1yguA:
undetectable		 4a97H-1yguA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZS_A_SAMA1475_1
(METHYLTRANSFERASE
WBDD)		 1ygu LEUKOCYTE COMMON
ANTIGEN
(Homo
sapiens) 		3 / 3 ARG A 930
ASP A1146
GLN A1149
 None
 0.77A 4azsA-1yguA:
undetectable		 4azsA-1yguA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQF_A_QPSA951_1
(ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC)		 1ygu LEUKOCYTE COMMON
ANTIGEN
(Homo
sapiens) 		4 / 6 GLY A 679
ARG A 713
GLU A 670
ARG A 668
 None
 1.26A 4bqfA-1yguA:
2.2		 4bqfA-1yguA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLA_A_CHDA501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1ygu LEUKOCYTE COMMON
ANTIGEN
(Homo
sapiens) 		4 / 7 MET A 714
ARG A 867
VAL A 826
MET A 725
 None
 1.48A 4klaA-1yguA:
0.0		 4klaA-1yguA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O5F_A_PAUA301_0
(TYPE III
PANTOTHENATE KINASE)		 1ygu LEUKOCYTE COMMON
ANTIGEN
(Homo
sapiens) 		5 / 12 ASN A 994
VAL A 952
GLY A1185
ASP A1146
THR A1151
 None
 1.25A 4o5fA-1yguA:
undetectable
4o5fB-1yguA:
undetectable		 4o5fA-1yguA:
16.26
4o5fB-1yguA:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O5F_B_PAUB302_0
(TYPE III
PANTOTHENATE KINASE)		 1ygu LEUKOCYTE COMMON
ANTIGEN
(Homo
sapiens) 		5 / 12 ASN A 994
VAL A 952
GLY A1185
ASP A1146
THR A1151
 None
 1.25A 4o5fA-1yguA:
undetectable
4o5fB-1yguA:
undetectable		 4o5fA-1yguA:
16.26
4o5fB-1yguA:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8Z_A_BBIA402_1
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL)		 1ygu LEUKOCYTE COMMON
ANTIGEN
(Homo
sapiens) 		4 / 5 HIS A 788
PHE A 711
LEU A 772
PRO A 742
 None
 1.25A 4o8zA-1yguA:
undetectable		 4o8zA-1yguA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_E_377E401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1ygu LEUKOCYTE COMMON
ANTIGEN
(Homo
sapiens) 		4 / 6 TYR A 903
ASN A 906
GLU A 922
TYR A1197
 None
 1.23A 4twdD-1yguA:
undetectable
4twdE-1yguA:
undetectable		 4twdD-1yguA:
20.03
4twdE-1yguA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_D_ACTD406_0
(PROTON-GATED ION
CHANNEL)		 1ygu LEUKOCYTE COMMON
ANTIGEN
(Homo
sapiens) 		4 / 4 ILE A 644
ILE A 661
ARG A 637
TYR A 664
 None
 1.35A 4zzcD-1yguA:
0.0		 4zzcD-1yguA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8H_A_PAUA302_0
(TYPE III
PANTOTHENATE KINASE)		 1ygu LEUKOCYTE COMMON
ANTIGEN
(Homo
sapiens) 		5 / 12 ASN A 994
VAL A 952
GLY A1185
ASP A1146
THR A1151
 None
 1.24A 5b8hA-1yguA:
undetectable
5b8hB-1yguA:
undetectable		 5b8hA-1yguA:
16.58
5b8hB-1yguA:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8H_B_PAUB302_0
(TYPE III
PANTOTHENATE KINASE)		 1ygu LEUKOCYTE COMMON
ANTIGEN
(Homo
sapiens) 		5 / 12 ASN A 994
VAL A 952
GLY A1185
ASP A1146
THR A1151
 None
 1.23A 5b8hA-1yguA:
undetectable
5b8hB-1yguA:
undetectable		 5b8hA-1yguA:
16.58
5b8hB-1yguA:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HBS_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 1ygu LEUKOCYTE COMMON
ANTIGEN
(Homo
sapiens) 		4 / 8 LEU A 897
LEU A1161
TYR A1197
GLN A1174
 None
 1.16A 5hbsA-1yguA:
undetectable		 5hbsA-1yguA:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M24_A_9CRA501_1
(RETINOIC ACID
RECEPTOR GAMMA)		 1ygu LEUKOCYTE COMMON
ANTIGEN
(Homo
sapiens) 		5 / 12 ALA A1156
LEU A1179
GLY A1147
LEU A1036
ILE A1153
 None
 1.09A 5m24A-1yguA:
undetectable		 5m24A-1yguA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODI_G_ACTG702_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 1ygu LEUKOCYTE COMMON
ANTIGEN
(Homo
sapiens) 		3 / 3 GLY A 822
THR A 721
ASN A 818
 None
 0.67A 5odiG-1yguA:
undetectable		 5odiG-1yguA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_H_CVIH301_1
(REGULATORY PROTEIN
TETR)		 1ygu LEUKOCYTE COMMON
ANTIGEN
(Homo
sapiens) 		4 / 8 GLN A 872
GLY A 836
ILE A 880
TRP A 794
 None
 0.87A 5vlmH-1yguA:
0.3		 5vlmH-1yguA:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC608_1
(ALPHA-AMYLASE)		 1ygu LEUKOCYTE COMMON
ANTIGEN
(Homo
sapiens) 		3 / 3 TYR A 877
ALA A 883
LEU A 884
 None
 0.54A 6ag0C-1yguA:
undetectable		 6ag0C-1yguA:
8.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_B_RFPB502_2
(RIFAMPIN
MONOOXYGENASE)		 1ygu LEUKOCYTE COMMON
ANTIGEN
(Homo
sapiens) 		4 / 6 GLN A1094
VAL A1119
LEU A1039
ARG A1145
 None
 1.27A 6brdB-1yguA:
undetectable		 6brdB-1yguA:
9.57