SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1yht'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AM6_A_HAEA555_1
(CARBONIC ANHYDRASE)		 1yht DSPB
(Aggregatibacter
actinomycetemcom
itans) 		4 / 7 HIS A 179
HIS A  51
LEU A 270
THR A 235
 None
 1.04A 1am6A-1yhtA:
undetectable		 1am6A-1yhtA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICT_D_T44D129_1
(TRANSTHYRETIN)		 1yht DSPB
(Aggregatibacter
actinomycetemcom
itans) 		4 / 6 LEU A 277
ALA A 325
LEU A 327
THR A  19
 None
 0.86A 1ictB-1yhtA:
undetectable		 1ictB-1yhtA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_5
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1yht DSPB
(Aggregatibacter
actinomycetemcom
itans) 		3 / 3 THR A 346
LEU A 350
VAL A 353
 None
 0.27A 1mz9E-1yhtA:
undetectable		 1mz9E-1yhtA:
8.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJD_A_C2FA315_0
(UNCHARACTERIZED
PROTEIN)		 1yht DSPB
(Aggregatibacter
actinomycetemcom
itans) 		5 / 11 THR A 357
THR A  19
VAL A 298
LYS A 296
ILE A 299
 None
 1.45A 3ijdA-1yhtA:
9.8		 3ijdA-1yhtA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LMY_A_CP6A562_1
(BETA-HEXOSAMINIDASE
SUBUNIT BETA)		 1yht DSPB
(Aggregatibacter
actinomycetemcom
itans) 		10 / 12 ARG A  27
HIS A  53
ASP A  56
ASP A 116
HIS A 120
ASP A 183
TRP A 237
TYR A 278
TRP A 330
GLU A 332
 GOL  A 751 (-3.2A)
None
None
None
None
ACY  A 750 (-3.5A)
ACY  A 750 (-3.4A)
ACY  A 750 (-4.6A)
GOL  A 751 ( 4.0A)
GOL  A 751 (-2.9A)
 0.60A 3lmyA-1yhtA:
29.1		 3lmyA-1yhtA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LMY_B_CP6B563_1
(BETA-HEXOSAMINIDASE
SUBUNIT BETA)		 1yht DSPB
(Aggregatibacter
actinomycetemcom
itans) 		12 / 12 ARG A  27
HIS A  53
ASP A  56
ASP A 116
HIS A 120
ASP A 183
GLU A 184
TRP A 216
TRP A 237
TYR A 278
TRP A 330
GLU A 332
 GOL  A 751 (-3.2A)
None
None
None
None
ACY  A 750 (-3.5A)
ACY  A 750 ( 3.8A)
ACY  A 750 (-3.2A)
ACY  A 750 (-3.4A)
ACY  A 750 (-4.6A)
GOL  A 751 ( 4.0A)
GOL  A 751 (-2.9A)
 0.57A 3lmyB-1yhtA:
29.1		 3lmyB-1yhtA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S79_A_ASDA601_1
(CYTOCHROME P450 19A1)		 1yht DSPB
(Aggregatibacter
actinomycetemcom
itans) 		5 / 12 TRP A 302
ILE A 322
THR A  19
LEU A 349
LEU A 277
 None
 1.24A 3s79A-1yhtA:
undetectable		 3s79A-1yhtA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VET_A_TOYA604_1
(O-CARBAMOYLTRANSFERA
SE TOBZ)		 1yht DSPB
(Aggregatibacter
actinomycetemcom
itans) 		5 / 9 ASP A  24
TYR A 278
GLU A 184
ASP A 242
ASP A  56
 None
ACY  A 750 (-4.6A)
ACY  A 750 ( 3.8A)
None
None
 1.48A 3vetA-1yhtA:
0.0		 3vetA-1yhtA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W6H_A_AZMA303_1
(CARBONIC ANHYDRASE 1)		 1yht DSPB
(Aggregatibacter
actinomycetemcom
itans) 		4 / 8 HIS A 179
HIS A  51
LEU A 270
THR A 235
 None
 1.06A 3w6hA-1yhtA:
undetectable		 3w6hA-1yhtA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		 1yht DSPB
(Aggregatibacter
actinomycetemcom
itans) 		4 / 7 LEU A 277
ALA A 325
LEU A 327
THR A  19
 None
 0.80A 4d7bA-1yhtA:
undetectable		 4d7bA-1yhtA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G24_A_ACAA1004_1
(PENTATRICOPEPTIDE
REPEAT-CONTAINING
PROTEIN AT2G32230,
MITOCHONDRIAL)		 1yht DSPB
(Aggregatibacter
actinomycetemcom
itans) 		4 / 6 ALA A 325
LEU A 270
VAL A 269
GLU A 321
 None
 0.86A 4g24A-1yhtA:
undetectable		 4g24A-1yhtA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JKV_A_ASDA602_1
(AROMATASE)		 1yht DSPB
(Aggregatibacter
actinomycetemcom
itans) 		5 / 12 TRP A 302
ILE A 322
THR A  19
LEU A 349
LEU A 277
 None
 1.24A 5jkvA-1yhtA:
undetectable		 5jkvA-1yhtA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_H_BO2H306_1
(PROTEASOME SUBUNIT
BETA TYPE-7
PROTEASOME SUBUNIT
BETA TYPE-3)		 1yht DSPB
(Aggregatibacter
actinomycetemcom
itans) 		5 / 10 THR A 357
THR A 319
GLU A 321
ALA A 325
ALA A 323
 None
 1.20A 5lf3H-1yhtA:
undetectable
5lf3I-1yhtA:
undetectable		 5lf3H-1yhtA:
21.01
5lf3I-1yhtA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_V_BO2V303_1
(PROTEASOME SUBUNIT
BETA TYPE-7
PROTEASOME SUBUNIT
BETA TYPE-3)		 1yht DSPB
(Aggregatibacter
actinomycetemcom
itans) 		5 / 10 THR A 357
THR A 319
GLU A 321
ALA A 325
ALA A 323
 None
 1.21A 5lf3V-1yhtA:
undetectable
5lf3W-1yhtA:
undetectable		 5lf3V-1yhtA:
21.01
5lf3W-1yhtA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUE_A_VIVA302_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 1yht DSPB
(Aggregatibacter
actinomycetemcom
itans) 		5 / 12 VAL A  34
ILE A 329
LEU A 327
VAL A 353
PHE A 287
 None
 0.96A 5mueA-1yhtA:
1.5		 5mueA-1yhtA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V5Z_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1yht DSPB
(Aggregatibacter
actinomycetemcom
itans) 		3 / 3 GLY A 219
THR A 122
PRO A 118
 None
 0.60A 5v5zA-1yhtA:
undetectable		 5v5zA-1yhtA:
23.09