SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1yhu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_C_DVAC6_0
(GRAMICIDIN A)		 1yhu HEMOGLOBIN B1A CHAIN
(Riftia
pachyptila) 		3 / 3 ALA C  24
VAL C  19
TRP C  16
 None
 0.73A 1av2C-1yhuC:
undetectable
1av2D-1yhuC:
undetectable		 1av2C-1yhuC:
5.97
1av2D-1yhuC:
5.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EUP_A_ASDA452_1
(CYTOCHROME P450ERYF)		 1yhu HEMOGLOBIN B2 CHAIN
(Riftia
pachyptila) 		4 / 8 PHE D 136
LEU D  94
LEU D  74
LEU D  91
 None
None
HEM  D 160 (-3.7A)
None
 0.85A 1eupA-1yhuD:
undetectable		 1eupA-1yhuD:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FK9_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		 1yhu HEMOGLOBIN A1 CHAIN
(Riftia
pachyptila) 		5 / 10 LEU A  72
VAL A 117
VAL A  12
TYR A 134
LEU A  33
 HEM  A 160 (-4.5A)
None
None
None
None
 1.42A 1fk9A-1yhuA:
undetectable		 1fk9A-1yhuA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKP_A_NVPA999_1
(HIV-1 RT, A-CHAIN)		 1yhu HEMOGLOBIN A1 CHAIN
(Riftia
pachyptila) 		5 / 11 LEU A  72
VAL A 117
VAL A  12
TYR A 134
LEU A  33
 HEM  A 160 (-4.5A)
None
None
None
None
 1.27A 1fkpA-1yhuA:
undetectable		 1fkpA-1yhuA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_C_CCSC47_0
(GLUTATHIONE
S-TRANSFERASE)		 1yhu GIANT HEMOGLOBINS B
CHAIN
(Riftia
pachyptila) 		4 / 6 THR B  66
LEU B  69
GLY B  71
TYR B  20
 None
None
HEM  B 160 ( 4.5A)
None
 1.15A 1gtiC-1yhuB:
undetectable		 1gtiC-1yhuB:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JR1_B_MOAB1333_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)		 1yhu GIANT HEMOGLOBINS B
CHAIN
HEMOGLOBIN B2 CHAIN
(Riftia
pachyptila) 		4 / 8 ASP B  73
ARG D  28
GLY D  17
GLY B  21
 None
 0.75A 1jr1B-1yhuB:
undetectable		 1jr1B-1yhuB:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KF6_N_ACTN803_0
(FUMARATE REDUCTASE
FLAVOPROTEIN
FUMARATE REDUCTASE
IRON-SULFUR PROTEIN)		 1yhu GIANT HEMOGLOBINS B
CHAIN
HEMOGLOBIN B2 CHAIN
(Riftia
pachyptila;
Riftia
pachyptila) 		4 / 6 TRP D  20
ARG D  28
GLY B  70
ASP B  73
 None
 1.02A 1kf6M-1yhuD:
undetectable
1kf6N-1yhuD:
1.4		 1kf6M-1yhuD:
14.34
1kf6N-1yhuD:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 1yhu GIANT HEMOGLOBINS B
CHAIN
HEMOGLOBIN B2 CHAIN
(Riftia
pachyptila;
Riftia
pachyptila) 		5 / 12 TYR B  20
ILE D  68
GLY B  71
GLY D  73
SER D  76
 None
None
HEM  B 160 ( 4.5A)
HEM  D 160 ( 4.1A)
None
 1.07A 1kiaA-1yhuB:
undetectable		 1kiaA-1yhuB:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_A_DVAA6_0
(MINI-GRAMICIDIN A)		 1yhu HEMOGLOBIN A1 CHAIN
(Riftia
pachyptila) 		3 / 3 ALA A 115
VAL A 117
TRP A 130
 None
 0.88A 1kqeA-1yhuA:
undetectable
1kqeE-1yhuA:
undetectable		 1kqeA-1yhuA:
5.43
1kqeE-1yhuA:
5.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_D_DVAD6_0
(MINI-GRAMICIDIN A)		 1yhu HEMOGLOBIN A1 CHAIN
(Riftia
pachyptila) 		3 / 3 TRP A 130
ALA A 115
VAL A 117
 None
 0.89A 1kqeB-1yhuA:
undetectable
1kqeD-1yhuA:
undetectable		 1kqeB-1yhuA:
5.43
1kqeD-1yhuA:
5.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LW0_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 1yhu HEMOGLOBIN A1 CHAIN
(Riftia
pachyptila) 		5 / 10 LEU A  72
VAL A 117
VAL A  12
TYR A 134
LEU A  33
 HEM  A 160 (-4.5A)
None
None
None
None
 1.28A 1lw0A-1yhuA:
2.1		 1lw0A-1yhuA:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LWC_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 1yhu HEMOGLOBIN A1 CHAIN
(Riftia
pachyptila) 		5 / 11 LEU A  72
VAL A 117
VAL A  12
TYR A 134
LEU A  33
 HEM  A 160 (-4.5A)
None
None
None
None
 1.29A 1lwcA-1yhuA:
undetectable		 1lwcA-1yhuA:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT6_A_DVAA6_0
(GRAMICIDIN C)		 1yhu HEMOGLOBIN B1A CHAIN
(Riftia
pachyptila) 		3 / 3 ALA C  24
VAL C  19
TRP C  16
 None
 0.87A 1nt6A-1yhuC:
undetectable		 1nt6A-1yhuC:
10.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT6_B_DVAB6_0
(GRAMICIDIN C)		 1yhu HEMOGLOBIN B1A CHAIN
(Riftia
pachyptila) 		3 / 3 ALA C  24
VAL C  19
TRP C  16
 None
 0.87A 1nt6B-1yhuC:
undetectable		 1nt6B-1yhuC:
10.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SV5_A_65BA600_0
(REVERSE
TRANSCRIPTASE)		 1yhu HEMOGLOBIN A1 CHAIN
(Riftia
pachyptila) 		5 / 10 LEU A  72
VAL A 117
VAL A  12
TYR A 134
LEU A  33
 HEM  A 160 (-4.5A)
None
None
None
None
 1.18A 1sv5A-1yhuA:
1.6		 1sv5A-1yhuA:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VRT_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 1yhu HEMOGLOBIN A1 CHAIN
(Riftia
pachyptila) 		5 / 9 LEU A  72
VAL A 117
VAL A  12
TYR A 134
LEU A  33
 HEM  A 160 (-4.5A)
None
None
None
None
 1.23A 1vrtA-1yhuA:
undetectable		 1vrtA-1yhuA:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_C_DVAC6_0
(GRAMICIDIN D)		 1yhu HEMOGLOBIN B1A CHAIN
(Riftia
pachyptila) 		3 / 3 ALA C  24
VAL C  19
TRP C  16
 None
 0.75A 1w5uC-1yhuC:
undetectable
1w5uD-1yhuC:
undetectable		 1w5uC-1yhuC:
5.97
1w5uD-1yhuC:
5.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_D_TFPD207_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 1yhu HEMOGLOBIN B2 CHAIN
(Riftia
pachyptila) 		4 / 8 LEU D 147
PHE D 109
PHE D 136
MET D 143
 None
HEM  D 160 (-3.5A)
None
HEM  D 160 (-3.5A)
 1.00A 1wrlC-1yhuD:
undetectable
1wrlD-1yhuD:
undetectable		 1wrlC-1yhuD:
18.67
1wrlD-1yhuD:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HND_A_NVPA999_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 1yhu HEMOGLOBIN A1 CHAIN
(Riftia
pachyptila) 		5 / 10 LEU A  72
VAL A 117
VAL A  12
TYR A 134
LEU A  33
 HEM  A 160 (-4.5A)
None
None
None
None
 1.29A 2hndA-1yhuA:
2.4		 2hndA-1yhuA:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HNY_A_NVPA999_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 1yhu HEMOGLOBIN A1 CHAIN
(Riftia
pachyptila) 		5 / 10 LEU A  72
VAL A 117
VAL A  12
TYR A 134
LEU A  33
 HEM  A 160 (-4.5A)
None
None
None
None
 1.30A 2hnyA-1yhuA:
undetectable		 2hnyA-1yhuA:
14.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IVU_A_ZD6A3015_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		 1yhu HEMOGLOBIN B1A CHAIN
(Riftia
pachyptila) 		3 / 3 ALA C 114
GLY C 139
SER C 145
 None
 0.58A 2ivuA-1yhuC:
undetectable		 2ivuA-1yhuC:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_B_DVAB6_0
(GRAMICIDIN D)		 1yhu HEMOGLOBIN B1A CHAIN
(Riftia
pachyptila) 		3 / 3 TRP C  16
ALA C  24
VAL C  19
 None
 0.69A 2izqA-1yhuC:
undetectable
2izqB-1yhuC:
undetectable		 2izqA-1yhuC:
5.97
2izqB-1yhuC:
5.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q72_A_IXXA801_1
(TRANSPORTER)		 1yhu GIANT HEMOGLOBINS B
CHAIN
(Riftia
pachyptila) 		5 / 11 LEU B  89
LEU B  85
ILE B 138
ALA B  77
LEU B  72
 None
None
None
None
HEM  B 160 (-4.3A)
 1.10A 2q72A-1yhuB:
undetectable		 2q72A-1yhuB:
13.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QJU_A_DSMA801_1
(TRANSPORTER)		 1yhu GIANT HEMOGLOBINS B
CHAIN
(Riftia
pachyptila) 		5 / 11 LEU B  89
LEU B  85
ILE B 138
ALA B  77
LEU B  72
 None
None
None
None
HEM  B 160 (-4.3A)
 1.09A 2qjuA-1yhuB:
undetectable		 2qjuA-1yhuB:
13.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_A_DVAA6_0
(GRAMICIDIN D)		 1yhu HEMOGLOBIN B1A CHAIN
(Riftia
pachyptila) 		3 / 3 ALA C  24
VAL C  19
TRP C  16
 None
 0.70A 3l8lA-1yhuC:
undetectable
3l8lB-1yhuC:
undetectable		 3l8lA-1yhuC:
5.97
3l8lB-1yhuC:
8.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_C_DVAC6_0
(GRAMICIDIN D)		 1yhu HEMOGLOBIN B1A CHAIN
(Riftia
pachyptila) 		3 / 3 ALA C  24
VAL C  19
TRP C  16
 None
 0.82A 3l8lC-1yhuC:
undetectable
3l8lD-1yhuC:
undetectable		 3l8lC-1yhuC:
5.97
3l8lD-1yhuC:
8.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LP1_A_NVPA701_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 1yhu HEMOGLOBIN A1 CHAIN
(Riftia
pachyptila) 		5 / 10 LEU A  72
VAL A 117
VAL A  12
TYR A 134
LEU A  33
 HEM  A 160 (-4.5A)
None
None
None
None
 1.41A 3lp1A-1yhuA:
undetectable		 3lp1A-1yhuA:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MIH_A_CUA358_0
(PEPTIDYL-GLYCINE
ALPHA-AMIDATING
MONOOXYGENASE)		 1yhu GIANT HEMOGLOBINS B
CHAIN
(Riftia
pachyptila) 		3 / 3 HIS B  36
HIS B 111
MET B 115
 ZN  B 191 (-3.3A)
ZN  B 191 (-3.4A)
ZN  B 191 ( 4.8A)
 0.83A 3mihA-1yhuB:
undetectable		 3mihA-1yhuB:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V81_C_NVPC901_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 1yhu HEMOGLOBIN A1 CHAIN
(Riftia
pachyptila) 		4 / 8 LEU A  72
VAL A 117
TYR A 134
LEU A  33
 HEM  A 160 (-4.5A)
None
None
None
 1.04A 3v81C-1yhuA:
2.1		 3v81C-1yhuA:
14.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VT7_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 1yhu HEMOGLOBIN B2 CHAIN
(Riftia
pachyptila) 		5 / 12 LEU D  39
VAL D  35
SER D 115
ARG D 118
VAL D  58
 None
 1.43A 3vt7A-1yhuD:
undetectable		 3vt7A-1yhuD:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEL_A_ACRA1001_2
(ALPHA-GLUCOSIDASE)		 1yhu HEMOGLOBIN A1 CHAIN
(Riftia
pachyptila) 		4 / 6 ILE A 114
ILE A  65
TRP A  34
TRP A  16
 None
 1.41A 3welA-1yhuA:
undetectable		 3welA-1yhuA:
9.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B3Q_A_NVPA999_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 1yhu HEMOGLOBIN A1 CHAIN
(Riftia
pachyptila) 		4 / 7 LEU A  72
VAL A 117
TYR A 134
LEU A  33
 HEM  A 160 (-4.5A)
None
None
None
 0.94A 4b3qA-1yhuA:
undetectable		 4b3qA-1yhuA:
13.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_A_ECNA403_1
(FLAVOHEMOGLOBIN)		 1yhu HEMOGLOBIN A1 CHAIN
(Riftia
pachyptila) 		5 / 12 ALA A 112
LEU A 113
THR A 116
VAL A  68
LEU A  72
 None
None
None
OXY  A 161 (-4.2A)
HEM  A 160 (-4.5A)
 1.13A 4g1bA-1yhuA:
13.5		 4g1bA-1yhuA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_B_ECNB403_1
(FLAVOHEMOGLOBIN)		 1yhu HEMOGLOBIN A1 CHAIN
(Riftia
pachyptila) 		5 / 11 ALA A 112
LEU A 113
THR A 116
VAL A 117
LEU A  72
 None
None
None
None
HEM  A 160 (-4.5A)
 1.08A 4g1bB-1yhuA:
13.1		 4g1bB-1yhuA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_B_ECNB403_1
(FLAVOHEMOGLOBIN)		 1yhu HEMOGLOBIN A1 CHAIN
(Riftia
pachyptila) 		5 / 11 ALA A 112
LEU A 113
THR A 116
VAL A 117
TYR A  20
 None
 0.84A 4g1bB-1yhuA:
13.1		 4g1bB-1yhuA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_B_CHDB502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1yhu GIANT HEMOGLOBINS B
CHAIN
(Riftia
pachyptila) 		4 / 6 PHE B  61
ILE B  56
ARG B  45
VAL B 109
 None
None
None
HEM  B 160 (-4.5A)
 1.29A 4mk4B-1yhuB:
undetectable		 4mk4B-1yhuB:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PUO_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 1yhu HEMOGLOBIN A1 CHAIN
(Riftia
pachyptila) 		5 / 9 LEU A  72
VAL A 117
VAL A  12
TYR A 134
LEU A  33
 HEM  A 160 (-4.5A)
None
None
None
None
 1.18A 4puoA-1yhuA:
undetectable		 4puoA-1yhuA:
14.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PUO_C_NVPC901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 1yhu HEMOGLOBIN A1 CHAIN
(Riftia
pachyptila) 		5 / 8 LEU A  72
VAL A 117
VAL A  12
TYR A 134
LEU A  33
 HEM  A 160 (-4.5A)
None
None
None
None
 1.26A 4puoC-1yhuA:
2.2		 4puoC-1yhuA:
14.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWD_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 1yhu HEMOGLOBIN A1 CHAIN
(Riftia
pachyptila) 		5 / 8 LEU A  72
VAL A 117
VAL A  12
TYR A 134
LEU A  33
 HEM  A 160 (-4.5A)
None
None
None
None
 1.22A 4pwdA-1yhuA:
undetectable		 4pwdA-1yhuA:
14.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWD_C_NVPC901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 1yhu HEMOGLOBIN A1 CHAIN
(Riftia
pachyptila) 		4 / 8 LEU A  72
VAL A 117
TYR A 134
LEU A  33
 HEM  A 160 (-4.5A)
None
None
None
 1.00A 4pwdC-1yhuA:
undetectable		 4pwdC-1yhuA:
14.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0B_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 1yhu HEMOGLOBIN A1 CHAIN
(Riftia
pachyptila) 		4 / 8 LEU A  72
VAL A 117
TYR A 134
LEU A  33
 HEM  A 160 (-4.5A)
None
None
None
 0.95A 4q0bA-1yhuA:
undetectable		 4q0bA-1yhuA:
14.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0B_C_NVPC901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 1yhu HEMOGLOBIN A1 CHAIN
(Riftia
pachyptila) 		5 / 9 LEU A  72
VAL A 117
VAL A  12
TYR A 134
LEU A  33
 HEM  A 160 (-4.5A)
None
None
None
None
 1.27A 4q0bC-1yhuA:
undetectable		 4q0bC-1yhuA:
14.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYQ_A_3CJA607_1
(LACTOPEROXIDASE)		 1yhu GIANT HEMOGLOBINS B
CHAIN
HEMOGLOBIN B2 CHAIN
(Riftia
pachyptila) 		3 / 3 GLN B  95
HIS B  91
ARG D  69
 HEM  B 160 ( 3.7A)
HEM  D 160 (-3.9A)
None
 1.11A 4qyqA-1yhuB:
undetectable		 4qyqA-1yhuB:
12.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYQ_A_3CJA607_1
(LACTOPEROXIDASE)		 1yhu GIANT HEMOGLOBINS B
CHAIN
HEMOGLOBIN B2 CHAIN
(Riftia
pachyptila) 		3 / 3 GLN D  97
HIS D  93
ARG B  67
 HEM  D 160 ( 3.4A)
HEM  B 160 (-4.1A)
None
 1.10A 4qyqA-1yhuD:
undetectable		 4qyqA-1yhuD:
14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYQ_A_3CJA607_1
(LACTOPEROXIDASE)		 1yhu HEMOGLOBIN A1 CHAIN
HEMOGLOBIN B1A CHAIN
(Riftia
pachyptila) 		3 / 3 GLN A  95
HIS A  91
ARG C  70
 HEM  A 160 ( 3.3A)
HEM  C 160 (-4.1A)
None
 1.19A 4qyqA-1yhuA:
undetectable		 4qyqA-1yhuA:
12.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYQ_A_3CJA607_1
(LACTOPEROXIDASE)		 1yhu HEMOGLOBIN A1 CHAIN
HEMOGLOBIN B1A CHAIN
(Riftia
pachyptila) 		3 / 3 GLN C  98
HIS C  94
ARG A  67
 HEM  A 160 ( 3.4A)
HEM  A 160 (-3.8A)
None
 1.11A 4qyqA-1yhuC:
undetectable		 4qyqA-1yhuC:
12.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYQ_B_3CJB607_1
(LACTOPEROXIDASE)		 1yhu GIANT HEMOGLOBINS B
CHAIN
HEMOGLOBIN B2 CHAIN
(Riftia
pachyptila) 		3 / 3 GLN B  95
HIS B  91
ARG D  69
 HEM  B 160 ( 3.7A)
HEM  D 160 (-3.9A)
None
 1.15A 4qyqB-1yhuB:
undetectable		 4qyqB-1yhuB:
12.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYQ_B_3CJB607_1
(LACTOPEROXIDASE)		 1yhu GIANT HEMOGLOBINS B
CHAIN
HEMOGLOBIN B2 CHAIN
(Riftia
pachyptila) 		3 / 3 GLN D  97
HIS D  93
ARG B  67
 HEM  D 160 ( 3.4A)
HEM  B 160 (-4.1A)
None
 1.14A 4qyqB-1yhuD:
undetectable		 4qyqB-1yhuD:
14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYQ_B_3CJB607_1
(LACTOPEROXIDASE)		 1yhu HEMOGLOBIN A1 CHAIN
HEMOGLOBIN B1A CHAIN
(Riftia
pachyptila) 		3 / 3 GLN A  95
HIS A  91
ARG C  70
 HEM  A 160 ( 3.3A)
HEM  C 160 (-4.1A)
None
 1.21A 4qyqB-1yhuA:
undetectable		 4qyqB-1yhuA:
12.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYQ_B_3CJB607_1
(LACTOPEROXIDASE)		 1yhu HEMOGLOBIN A1 CHAIN
HEMOGLOBIN B1A CHAIN
(Riftia
pachyptila) 		3 / 3 GLN C  98
HIS C  94
ARG A  67
 HEM  A 160 ( 3.4A)
HEM  A 160 (-3.8A)
None
 1.15A 4qyqB-1yhuC:
undetectable		 4qyqB-1yhuC:
12.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HBM_A_NVPA601_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 1yhu HEMOGLOBIN A1 CHAIN
(Riftia
pachyptila) 		5 / 11 LEU A  72
VAL A 117
VAL A  12
TYR A 134
LEU A  33
 HEM  A 160 (-4.5A)
None
None
None
None
 1.24A 5hbmA-1yhuA:
undetectable		 5hbmA-1yhuA:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_H_ACTH614_0
(NADH DEHYDROGENASE,
PUTATIVE)		 1yhu HEMOGLOBIN A1 CHAIN
(Riftia
pachyptila) 		4 / 6 ILE A  76
VAL A 117
TYR A  20
TRP A 130
 None
 1.00A 5jwaH-1yhuA:
undetectable		 5jwaH-1yhuA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U4S_B_BEZB301_0
(PUTATIVE SHORT CHAIN
DEHYDROGENASE)		 1yhu HEMOGLOBIN B2 CHAIN
(Riftia
pachyptila) 		4 / 8 SER D  77
ILE D  78
LEU D  74
MET D  12
 HEM  D 160 ( 4.7A)
None
HEM  D 160 (-3.7A)
None
 0.64A 5u4sB-1yhuD:
undetectable		 5u4sB-1yhuD:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_A_AQ4A602_1
(CYTOCHROME P450 1A1)		 1yhu HEMOGLOBIN B1A CHAIN
(Riftia
pachyptila) 		4 / 5 ILE C 144
SER C 145
ALA C 114
LEU C  75
 None
None
None
HEM  C 160 ( 4.7A)
 0.95A 6dwnA-1yhuC:
undetectable		 6dwnA-1yhuC:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FOS_A_PQNA2001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 1yhu HEMOGLOBIN A1 CHAIN
(Riftia
pachyptila) 		4 / 6 TRP A  34
GLY A 119
ALA A  32
LEU A  33
 None
 0.96A 6fosA-1yhuA:
undetectable		 6fosA-1yhuA:
22.76