SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1yi7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JR1_A_MOAA1332_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)		 1yi7 BETA-XYLOSIDASE,
FAMILY 43 GLYCOSYL
HYDROLASE
(Clostridium
acetobutylicum) 		5 / 11 ASP A  15
ARG A 288
GLY A 504
THR A  95
GLY A  72
 GOL  A3020 (-2.6A)
GOL  A3020 (-2.5A)
None
None
None
 1.41A 1jr1A-1yi7A:
undetectable		 1jr1A-1yi7A:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_B_SAMB200_0
(METHIONINE REPRESSOR)		 1yi7 BETA-XYLOSIDASE,
FAMILY 43 GLYCOSYL
HYDROLASE
(Clostridium
acetobutylicum) 		4 / 4 HIS A 249
ALA A 250
PHE A 201
GLY A 188
 GOL  A3020 ( 4.8A)
None
None
None
 1.42A 1mjoA-1yi7A:
undetectable		 1mjoA-1yi7A:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSI_B_H4BB601_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 1yi7 BETA-XYLOSIDASE,
FAMILY 43 GLYCOSYL
HYDROLASE
(Clostridium
acetobutylicum) 		4 / 6 GLU A  33
ARG A 288
ILE A  73
TRP A  74
 None
GOL  A3020 (-2.5A)
None
GOL  A3020 (-4.3A)
 1.47A 1nsiA-1yi7A:
undetectable
1nsiB-1yi7A:
undetectable		 1nsiA-1yi7A:
20.81
1nsiB-1yi7A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OS6_A_DXCA75_0
(PPCA)		 1yi7 BETA-XYLOSIDASE,
FAMILY 43 GLYCOSYL
HYDROLASE
(Clostridium
acetobutylicum) 		4 / 8 ILE A 516
LEU A 372
PHE A 380
GLY A 512
 None
 0.98A 1os6A-1yi7A:
undetectable		 1os6A-1yi7A:
8.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_B_CHDB1131_0
(FATTY ACID-BINDING
PROTEIN)		 1yi7 BETA-XYLOSIDASE,
FAMILY 43 GLYCOSYL
HYDROLASE
(Clostridium
acetobutylicum) 		5 / 10 LEU A 495
ILE A 421
THR A 410
VAL A 486
PHE A 490
 None
 1.37A 1tw4B-1yi7A:
1.3		 1tw4B-1yi7A:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W0F_A_STRA1499_1
(CYTOCHROME P450 3A4)		 1yi7 BETA-XYLOSIDASE,
FAMILY 43 GLYCOSYL
HYDROLASE
(Clostridium
acetobutylicum) 		4 / 4 PHE A 530
ASP A 391
PHE A 390
VAL A 511
 None
 1.33A 1w0fA-1yi7A:
undetectable		 1w0fA-1yi7A:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AKE_A_TRPA479_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1yi7 BETA-XYLOSIDASE,
FAMILY 43 GLYCOSYL
HYDROLASE
(Clostridium
acetobutylicum) 		5 / 12 GLY A 368
GLY A 520
THR A 519
GLN A 405
PHE A 398
 None
 1.26A 2akeA-1yi7A:
undetectable		 2akeA-1yi7A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZX_A_TRPA601_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1yi7 BETA-XYLOSIDASE,
FAMILY 43 GLYCOSYL
HYDROLASE
(Clostridium
acetobutylicum) 		5 / 12 GLY A 368
GLY A 520
THR A 519
GLN A 405
PHE A 398
 None
 1.27A 2azxA-1yi7A:
undetectable		 2azxA-1yi7A:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X91_A_LPRA1615_2
(ANGIOTENSIN
CONVERTING ENZYME)		 1yi7 BETA-XYLOSIDASE,
FAMILY 43 GLYCOSYL
HYDROLASE
(Clostridium
acetobutylicum) 		3 / 3 SER A 496
THR A 507
PHE A 380
 None
 0.75A 2x91A-1yi7A:
undetectable		 2x91A-1yi7A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZN_B_SAMB402_0
(UNCHARACTERIZED
PROTEIN MJ0883)		 1yi7 BETA-XYLOSIDASE,
FAMILY 43 GLYCOSYL
HYDROLASE
(Clostridium
acetobutylicum) 		5 / 12 TYR A 412
PHE A 510
LEU A 346
GLY A 512
ILE A 421
 None
 1.31A 2zznB-1yi7A:
undetectable		 2zznB-1yi7A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_1
(RENIN)		 1yi7 BETA-XYLOSIDASE,
FAMILY 43 GLYCOSYL
HYDROLASE
(Clostridium
acetobutylicum) 		5 / 12 GLY A 188
THR A 207
ASP A 128
SER A  30
ALA A  75
 None
GOL  A3020 (-4.2A)
GOL  A3020 (-3.4A)
GOL  A3020 ( 4.5A)
GOL  A3020 (-3.3A)
 1.19A 3d91A-1yi7A:
undetectable		 3d91A-1yi7A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MJR_D_AC2D601_1
(DEOXYCYTIDINE KINASE)		 1yi7 BETA-XYLOSIDASE,
FAMILY 43 GLYCOSYL
HYDROLASE
(Clostridium
acetobutylicum) 		4 / 8 GLU A 289
TYR A 532
ARG A 268
PHE A 388
 None
 1.07A 3mjrD-1yi7A:
undetectable		 3mjrD-1yi7A:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SEL_X_DXCX75_0
(CYTOCHROME C7)		 1yi7 BETA-XYLOSIDASE,
FAMILY 43 GLYCOSYL
HYDROLASE
(Clostridium
acetobutylicum) 		4 / 8 ILE A 516
LEU A 372
PHE A 380
GLY A 512
 None
 0.86A 3selX-1yi7A:
undetectable		 3selX-1yi7A:
9.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SJ1_X_DXCX75_0
(CYTOCHROME C7)		 1yi7 BETA-XYLOSIDASE,
FAMILY 43 GLYCOSYL
HYDROLASE
(Clostridium
acetobutylicum) 		4 / 6 ILE A 516
LEU A 372
PHE A 380
GLY A 512
 None
 1.00A 3sj1X-1yi7A:
undetectable		 3sj1X-1yi7A:
9.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_A_AZMA229_2
(CARBONIC ANHYDRASE)		 1yi7 BETA-XYLOSIDASE,
FAMILY 43 GLYCOSYL
HYDROLASE
(Clostridium
acetobutylicum) 		3 / 3 GLN A 378
PHE A 380
TYR A 412
 None
 0.98A 3ucjB-1yi7A:
undetectable		 3ucjB-1yi7A:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_B_AZMB229_1
(CARBONIC ANHYDRASE)		 1yi7 BETA-XYLOSIDASE,
FAMILY 43 GLYCOSYL
HYDROLASE
(Clostridium
acetobutylicum) 		3 / 3 GLN A 378
PHE A 380
TYR A 412
 None
 1.00A 3ucjA-1yi7A:
undetectable		 3ucjA-1yi7A:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_D_H4BD600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 1yi7 BETA-XYLOSIDASE,
FAMILY 43 GLYCOSYL
HYDROLASE
(Clostridium
acetobutylicum) 		4 / 7 GLU A  33
ARG A 288
ILE A  73
TRP A  74
 None
GOL  A3020 (-2.5A)
None
GOL  A3020 (-4.3A)
 1.46A 4cx7C-1yi7A:
0.0
4cx7D-1yi7A:
0.0		 4cx7C-1yi7A:
20.81
4cx7D-1yi7A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HBF_A_DXCA75_0
(PPCA)		 1yi7 BETA-XYLOSIDASE,
FAMILY 43 GLYCOSYL
HYDROLASE
(Clostridium
acetobutylicum) 		4 / 7 ILE A 516
LEU A 372
PHE A 380
GLY A 512
 None
 1.02A 4hbfA-1yi7A:
undetectable		 4hbfA-1yi7A:
8.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HC3_A_DXCA75_0
(PPCA)		 1yi7 BETA-XYLOSIDASE,
FAMILY 43 GLYCOSYL
HYDROLASE
(Clostridium
acetobutylicum) 		4 / 7 ILE A 516
LEU A 372
PHE A 380
GLY A 512
 None
 0.94A 4hc3A-1yi7A:
undetectable		 4hc3A-1yi7A:
8.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NOS_B_H4BB1011_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 1yi7 BETA-XYLOSIDASE,
FAMILY 43 GLYCOSYL
HYDROLASE
(Clostridium
acetobutylicum) 		4 / 7 GLU A  33
ARG A 288
ILE A  73
TRP A  74
 None
GOL  A3020 (-2.5A)
None
GOL  A3020 (-4.3A)
 1.46A 4nosA-1yi7A:
undetectable
4nosB-1yi7A:
undetectable		 4nosA-1yi7A:
21.12
4nosB-1yi7A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NOS_C_H4BC2011_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 1yi7 BETA-XYLOSIDASE,
FAMILY 43 GLYCOSYL
HYDROLASE
(Clostridium
acetobutylicum) 		4 / 7 ARG A 288
ILE A  73
TRP A  74
GLU A  33
 GOL  A3020 (-2.5A)
None
GOL  A3020 (-4.3A)
None
 1.44A 4nosC-1yi7A:
undetectable
4nosD-1yi7A:
undetectable		 4nosC-1yi7A:
21.12
4nosD-1yi7A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NOS_D_H4BD3011_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 1yi7 BETA-XYLOSIDASE,
FAMILY 43 GLYCOSYL
HYDROLASE
(Clostridium
acetobutylicum) 		4 / 6 GLU A  33
ARG A 288
ILE A  73
TRP A  74
 None
GOL  A3020 (-2.5A)
None
GOL  A3020 (-4.3A)
 1.49A 4nosC-1yi7A:
undetectable
4nosD-1yi7A:
undetectable		 4nosC-1yi7A:
21.12
4nosD-1yi7A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_A_C2FA3000_1
(DIHYDROPTEROATE
SYNTHASE DHPS)		 1yi7 BETA-XYLOSIDASE,
FAMILY 43 GLYCOSYL
HYDROLASE
(Clostridium
acetobutylicum) 		3 / 3 LYS A 168
ASN A 123
ASP A 165
 None
 0.83A 4o1eA-1yi7A:
undetectable		 4o1eA-1yi7A:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_A_DGXA1107_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 1yi7 BETA-XYLOSIDASE,
FAMILY 43 GLYCOSYL
HYDROLASE
(Clostridium
acetobutylicum) 		4 / 4 ASN A 514
VAL A 396
THR A 420
ILE A 421
 None
 1.33A 4retA-1yi7A:
undetectable		 4retA-1yi7A:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_C_DGXC2005_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 1yi7 BETA-XYLOSIDASE,
FAMILY 43 GLYCOSYL
HYDROLASE
(Clostridium
acetobutylicum) 		4 / 4 ASN A 514
VAL A 396
THR A 420
ILE A 421
 None
 1.33A 4retC-1yi7A:
undetectable		 4retC-1yi7A:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZPH_A_PRLA501_0
(ARYL HYDROCARBON
RECEPTOR NUCLEAR
TRANSLOCATOR
ENDOTHELIAL PAS
DOMAIN-CONTAINING
PROTEIN 1)		 1yi7 BETA-XYLOSIDASE,
FAMILY 43 GLYCOSYL
HYDROLASE
(Clostridium
acetobutylicum) 		4 / 7 ARG A 294
VAL A 314
GLN A 293
GLU A 296
 None
 0.93A 4zphA-1yi7A:
undetectable
4zphB-1yi7A:
undetectable		 4zphA-1yi7A:
20.89
4zphB-1yi7A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_A_X2NA590_1
(CYP51 VARIANT1)		 1yi7 BETA-XYLOSIDASE,
FAMILY 43 GLYCOSYL
HYDROLASE
(Clostridium
acetobutylicum) 		5 / 12 ALA A 392
TYR A 532
ILE A  73
PHE A 510
LEU A  51
 None
 1.21A 5fsaA-1yi7A:
undetectable		 5fsaA-1yi7A:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_C_SAMC301_1
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 1yi7 BETA-XYLOSIDASE,
FAMILY 43 GLYCOSYL
HYDROLASE
(Clostridium
acetobutylicum) 		4 / 4 ASP A  15
HIS A 190
SER A 251
GLU A 213
 GOL  A3020 (-2.6A)
None
None
None
 1.24A 5hfjC-1yi7A:
0.0		 5hfjC-1yi7A:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5C_B_TA1B502_1
(TUBULIN BETA-2B
CHAIN)		 1yi7 BETA-XYLOSIDASE,
FAMILY 43 GLYCOSYL
HYDROLASE
(Clostridium
acetobutylicum) 		5 / 12 GLU A 289
ALA A 509
THR A 471
ARG A 268
LEU A 270
 None
 1.13A 5m5cB-1yi7A:
undetectable		 5m5cB-1yi7A:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_B_CVIB602_0
(ACETYLCHOLINESTERASE)		 1yi7 BETA-XYLOSIDASE,
FAMILY 43 GLYCOSYL
HYDROLASE
(Clostridium
acetobutylicum) 		4 / 8 TYR A  26
ASP A  24
THR A  23
VAL A 322
 None
 1.14A 5ov9B-1yi7A:
undetectable		 5ov9B-1yi7A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWO_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 1yi7 BETA-XYLOSIDASE,
FAMILY 43 GLYCOSYL
HYDROLASE
(Clostridium
acetobutylicum) 		5 / 9 TYR A  25
ASP A  45
ALA A 263
ILE A 292
SER A  43
 None
 1.32A 6awoA-1yi7A:
undetectable		 6awoA-1yi7A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWQ_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 1yi7 BETA-XYLOSIDASE,
FAMILY 43 GLYCOSYL
HYDROLASE
(Clostridium
acetobutylicum) 		5 / 9 TYR A  25
ASP A  45
ALA A 263
ILE A 292
SER A  43
 None
 1.32A 6awqA-1yi7A:
undetectable		 6awqA-1yi7A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BP4_A_SAMA505_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC)		 1yi7 BETA-XYLOSIDASE,
FAMILY 43 GLYCOSYL
HYDROLASE
(Clostridium
acetobutylicum) 		3 / 3 ILE A  27
ASN A   6
CYH A 247
 None
 0.83A 6bp4A-1yi7A:
undetectable		 6bp4A-1yi7A:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA807_0
(GEPHYRIN)		 1yi7 BETA-XYLOSIDASE,
FAMILY 43 GLYCOSYL
HYDROLASE
(Clostridium
acetobutylicum) 		4 / 4 PRO A 302
LEU A 252
VAL A 304
ARG A 303
 None
 1.43A 6fgdA-1yi7A:
0.0		 6fgdA-1yi7A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HZP_A_FVTA501_0
(PEPTIDE ABC
TRANSPORTER PERMEASE)		 1yi7 BETA-XYLOSIDASE,
FAMILY 43 GLYCOSYL
HYDROLASE
(Clostridium
acetobutylicum) 		4 / 8 GLN A 293
ASN A   6
PRO A   7
ILE A   8
 None
 1.00A 6hzpA-1yi7A:
undetectable		 6hzpA-1yi7A:
20.00