SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1yii'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_A_CCSA47_0
(GLUTATHIONE
S-TRANSFERASE)		 1yii ANNEXIN A5
(Gallus
gallus) 		4 / 7 LEU A 296
LEU A 314
GLY A 317
LEU A 281
 None
 0.89A 1gtiA-1yiiA:
undetectable		 1gtiA-1yiiA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_A_CFXA1300_2
(BETA-LACTAMASE)		 1yii ANNEXIN A5
(Gallus
gallus) 		4 / 5 TYR A 250
LEU A 281
THR A 268
ARG A 271
 None
 1.15A 1i2wA-1yiiA:
undetectable		 1i2wA-1yiiA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_B_THAB2_1
(LIVER
CARBOXYLESTERASE I)		 1yii ANNEXIN A5
(Gallus
gallus) 		5 / 11 LEU A 152
GLY A 199
VAL A 209
LEU A 206
LEU A 237
 None
 1.25A 1mx1B-1yiiA:
undetectable		 1mx1B-1yiiA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TZ8_C_DESC129_1
(TRANSTHYRETIN)		 1yii ANNEXIN A5
(Gallus
gallus) 		4 / 6 LEU A 157
ALA A 159
LEU A 114
SER A 116
 None
 1.04A 1tz8C-1yiiA:
undetectable
1tz8D-1yiiA:
undetectable		 1tz8C-1yiiA:
17.14
1tz8D-1yiiA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1291_1
(FICOLIN-2)		 1yii ANNEXIN A5
(Gallus
gallus) 		4 / 6 LEU A  73
SER A  71
ASP A  68
ASP A  67
 None
 1.14A 2j2pE-1yiiA:
undetectable
2j2pF-1yiiA:
undetectable		 2j2pE-1yiiA:
21.14
2j2pF-1yiiA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q7K_A_TESA304_1
(ANDROGEN RECEPTOR)		 1yii ANNEXIN A5
(Gallus
gallus) 		5 / 12 LEU A 312
LEU A 315
VAL A 272
MET A 259
LEU A 255
 None
 1.31A 2q7kA-1yiiA:
undetectable		 2q7kA-1yiiA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V2G_A_BEZA1222_0
(PEROXIREDOXIN 6)		 1yii ANNEXIN A5
(Gallus
gallus) 		4 / 7 THR A  79
VAL A  82
SER A  83
ARG A  86
 None
None
None
SO4  A 502 (-3.6A)
 1.05A 2v2gA-1yiiA:
undetectable
2v2gB-1yiiA:
undetectable		 2v2gA-1yiiA:
23.81
2v2gB-1yiiA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V2G_B_BEZB1220_0
(PEROXIREDOXIN 6)		 1yii ANNEXIN A5
(Gallus
gallus) 		4 / 7 THR A  79
VAL A  82
SER A  83
ARG A  86
 None
None
None
SO4  A 502 (-3.6A)
 1.06A 2v2gA-1yiiA:
undetectable
2v2gB-1yiiA:
undetectable		 2v2gA-1yiiA:
23.81
2v2gB-1yiiA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V2G_C_BEZC1222_0
(PEROXIREDOXIN 6)		 1yii ANNEXIN A5
(Gallus
gallus) 		4 / 7 THR A  79
VAL A  82
SER A  83
ARG A  86
 None
None
None
SO4  A 502 (-3.6A)
 1.06A 2v2gC-1yiiA:
undetectable
2v2gD-1yiiA:
undetectable		 2v2gC-1yiiA:
23.81
2v2gD-1yiiA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V2G_D_BEZD1221_0
(PEROXIREDOXIN 6)		 1yii ANNEXIN A5
(Gallus
gallus) 		4 / 7 THR A  79
VAL A  82
SER A  83
ARG A  86
 None
None
None
SO4  A 502 (-3.6A)
 1.06A 2v2gC-1yiiA:
undetectable
2v2gD-1yiiA:
undetectable		 2v2gC-1yiiA:
23.81
2v2gD-1yiiA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFH_A_CL6A1414_1
(ERYTHROMYCIN B/D
C-12 HYDROXYLASE)		 1yii ANNEXIN A5
(Gallus
gallus) 		4 / 8 LEU A  24
ILE A  38
LEU A  42
LEU A  65
 None
 0.74A 2xfhA-1yiiA:
undetectable		 2xfhA-1yiiA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TAJ_A_NBOA700_1
(LACTOTRANSFERRIN)		 1yii ANNEXIN A5
(Gallus
gallus) 		4 / 7 THR A 264
TYR A 308
GLY A  75
THR A  74
 CA  A 403 ( 4.8A)
None
None
None
 0.82A 3tajA-1yiiA:
undetectable		 3tajA-1yiiA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_A_MXMA606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1yii ANNEXIN A5
(Gallus
gallus) 		5 / 12 MET A  81
LEU A  42
LEU A  73
ALA A  27
LEU A  24
 None
 1.32A 4m11A-1yiiA:
0.5		 4m11A-1yiiA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_A_STRA604_1
(CYTOCHROME P450
21-HYDROXYLASE)		 1yii ANNEXIN A5
(Gallus
gallus) 		5 / 12 VAL A 178
LEU A 179
ILE A 197
VAL A 240
LEU A 152
 None
 0.92A 4y8wA-1yiiA:
undetectable		 4y8wA-1yiiA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_B_STRB603_1
(CYTOCHROME P450
21-HYDROXYLASE)		 1yii ANNEXIN A5
(Gallus
gallus) 		5 / 12 VAL A 178
LEU A 179
ILE A 197
VAL A 240
LEU A 152
 None
 0.94A 4y8wB-1yiiA:
undetectable		 4y8wB-1yiiA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AY6_A_VORA501_1
(CYP51, STEROL
14ALPHA-DEMETHYLASE)		 1yii ANNEXIN A5
(Gallus
gallus) 		5 / 9 ALA A  23
ALA A  27
THR A  33
LEU A  73
LEU A  39
 None
None
CA  A 401 ( 4.8A)
None
None
 1.42A 6ay6A-1yiiA:
undetectable		 6ay6A-1yiiA:
24.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_ACTA813_0
(GEPHYRIN)		 1yii ANNEXIN A5
(Gallus
gallus) 		3 / 3 THR A 111
ALA A 239
LYS A 242
 None
 0.76A 6fgcA-1yiiA:
undetectable		 6fgcA-1yiiA:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA817_0
(GEPHYRIN)		 1yii ANNEXIN A5
(Gallus
gallus) 		3 / 3 THR A 111
ALA A 239
LYS A 242
 None
 0.76A 6fgdA-1yiiA:
undetectable		 6fgdA-1yiiA:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_E_PCFE202_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL
CYTOCHROME C OXIDASE
SUBUNIT 1)		 1yii ANNEXIN A5
(Gallus
gallus) 		4 / 8 GLN A 220
VAL A 240
ARG A 245
ASP A 211
 None
 1.00A 6hu9a-1yiiA:
0.0
6hu9e-1yiiA:
0.8		 6hu9a-1yiiA:
19.22
6hu9e-1yiiA:
18.06