SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1yio'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I89_B_1FLB201_1
(TRANSTHYRETIN)		 1yio RESPONSE REGULATORY
PROTEIN
(Pseudomonas
fluorescens) 		4 / 4 LYS A  96
ALA A  97
SER A  74
THR A  71
 None
 1.47A 4i89B-1yioA:
undetectable		 4i89B-1yioA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_C_29SC601_1
(ESTROGEN RECEPTOR)		 1yio RESPONSE REGULATORY
PROTEIN
(Pseudomonas
fluorescens) 		5 / 12 ALA A  27
LEU A 113
LEU A 112
GLY A 119
LEU A 120
 None
None
None
None
HG  A 211 (-2.6A)
 1.06A 4xi3C-1yioA:
undetectable		 4xi3C-1yioA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWZ_B_BEZB301_0
(14-3-3 PROTEIN
ZETA/DELTA)		 1yio RESPONSE REGULATORY
PROTEIN
(Pseudomonas
fluorescens) 		3 / 3 MET A 182
GLN A 183
ARG A 188
 None
 1.06A 5ewzB-1yioA:
undetectable		 5ewzB-1yioA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M35_B_BEZB302_0
(14-3-3 PROTEIN
ZETA/DELTA)		 1yio RESPONSE REGULATORY
PROTEIN
(Pseudomonas
fluorescens) 		3 / 3 MET A 182
GLN A 183
ARG A 188
 None
 1.10A 5m35B-1yioA:
undetectable		 5m35B-1yioA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M36_A_BEZA303_0
(14-3-3 PROTEIN
ZETA/DELTA)		 1yio RESPONSE REGULATORY
PROTEIN
(Pseudomonas
fluorescens) 		3 / 3 MET A 182
GLN A 183
ARG A 188
 None
 1.09A 5m36A-1yioA:
undetectable		 5m36A-1yioA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_E_C2FE3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 1yio RESPONSE REGULATORY
PROTEIN
(Pseudomonas
fluorescens) 		5 / 12 ARG A  44
GLY A  50
GLY A  98
ARG A 130
ILE A  79
 None
HG  A 211 (-4.1A)
None
None
None
 1.05A 5vooE-1yioA:
2.8		 5vooE-1yioA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FN9_A_BEZA302_0
(14-3-3 PROTEIN
ZETA/DELTA)		 1yio RESPONSE REGULATORY
PROTEIN
(Pseudomonas
fluorescens) 		3 / 3 MET A 182
GLN A 183
ARG A 188
 None
 1.14A 6fn9A-1yioA:
undetectable		 6fn9A-1yioA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FNB_A_BEZA301_0
(14-3-3 PROTEIN
ZETA/DELTA)		 1yio RESPONSE REGULATORY
PROTEIN
(Pseudomonas
fluorescens) 		3 / 3 MET A 182
GLN A 183
ARG A 188
 None
 1.12A 6fnbA-1yioA:
undetectable		 6fnbA-1yioA:
22.83