SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1yiq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4001_1
(SERUM ALBUMIN)		 1yiq QUINOHEMOPROTEIN
ALCOHOL
DEHYDROGENASE
(Pseudomonas
putida) 		4 / 5 ARG A 624
ALA A 549
ASP A 622
GLY A 617
 PGR  A 805 (-4.2A)
None
PGR  A 805 (-3.4A)
PGR  A 805 ( 4.9A)
 1.15A 1e7cA-1yiqA:
2.2		 1e7cA-1yiqA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JO3_A_DVAA6_0
(GRAMICIDIN B)		 1yiq QUINOHEMOPROTEIN
ALCOHOL
DEHYDROGENASE
(Pseudomonas
putida) 		3 / 3 ALA A  10
VAL A   7
TRP A 120
 None
 0.93A 1jo3A-1yiqA:
undetectable		 1jo3A-1yiqA:
2.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JO3_B_DVAB6_0
(GRAMICIDIN B)		 1yiq QUINOHEMOPROTEIN
ALCOHOL
DEHYDROGENASE
(Pseudomonas
putida) 		3 / 3 ALA A  10
VAL A   7
TRP A 120
 None
 0.93A 1jo3B-1yiqA:
undetectable		 1jo3B-1yiqA:
2.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KB9_A_PCFA514_0
(CYTOCHROME B
CYTOCHROME C1, HEME
PROTEIN
UBIQUINOL-CYTOCHROME
C REDUCTASE COMPLEX
CORE PROTEIN I
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 1yiq QUINOHEMOPROTEIN
ALCOHOL
DEHYDROGENASE
(Pseudomonas
putida) 		4 / 8 SER A 239
HIS A 389
ILE A 405
SER A 343
 None
 1.08A 1kb9A-1yiqA:
undetectable
1kb9C-1yiqA:
undetectable
1kb9D-1yiqA:
4.6
1kb9E-1yiqA:
undetectable		 1kb9A-1yiqA:
20.40
1kb9C-1yiqA:
19.45
1kb9D-1yiqA:
16.98
1kb9E-1yiqA:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M4I_A_KANA500_1
(AMINOGLYCOSIDE
2'-N-ACETYLTRANSFERA
SE)		 1yiq QUINOHEMOPROTEIN
ALCOHOL
DEHYDROGENASE
(Pseudomonas
putida) 		4 / 8 ASP A 390
ASP A 297
THR A 294
ASP A 300
 PQQ  A 801 (-3.2A)
None
None
CA  A 802 (-3.1A)
 0.89A 1m4iA-1yiqA:
undetectable		 1m4iA-1yiqA:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_E_THAE5_1
(LIVER
CARBOXYLESTERASE I)		 1yiq QUINOHEMOPROTEIN
ALCOHOL
DEHYDROGENASE
(Pseudomonas
putida) 		5 / 12 GLY A 548
VAL A 615
LEU A 446
MET A 449
PHE A 385
 None
None
None
None
PGR  A 803 ( 4.3A)
 1.43A 1mx1E-1yiqA:
undetectable		 1mx1E-1yiqA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OLT_A_SAMA501_0
(OXYGEN-INDEPENDENT
COPROPORPHYRINOGEN
III OXIDASE)		 1yiq QUINOHEMOPROTEIN
ALCOHOL
DEHYDROGENASE
(Pseudomonas
putida) 		5 / 12 THR A 534
GLY A  90
ASP A  86
ILE A  93
ALA A 138
 None
 1.29A 1oltA-1yiqA:
undetectable		 1oltA-1yiqA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TV8_B_SAMB2501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 1yiq QUINOHEMOPROTEIN
ALCOHOL
DEHYDROGENASE
(Pseudomonas
putida) 		4 / 7 THR A 302
THR A 304
SER A 239
MET A 519
 PQQ  A 801 ( 4.5A)
None
None
None
 1.16A 1tv8B-1yiqA:
undetectable		 1tv8B-1yiqA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WG8_B_SAMB3141_0
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 1yiq QUINOHEMOPROTEIN
ALCOHOL
DEHYDROGENASE
(Pseudomonas
putida) 		5 / 12 GLY A 617
GLY A 548
GLY A 611
GLN A 557
ASP A 622
 PGR  A 805 ( 4.9A)
None
None
None
PGR  A 805 (-3.4A)
 0.80A 1wg8B-1yiqA:
undetectable		 1wg8B-1yiqA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_A_TEPA1434_1
(CHITINASE)		 1yiq QUINOHEMOPROTEIN
ALCOHOL
DEHYDROGENASE
(Pseudomonas
putida) 		3 / 3 TRP A 352
THR A 293
TYR A 332
 None
 1.27A 2a3aA-1yiqA:
undetectable		 2a3aA-1yiqA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3B_A_CFFA1434_1
(CHITINASE)		 1yiq QUINOHEMOPROTEIN
ALCOHOL
DEHYDROGENASE
(Pseudomonas
putida) 		3 / 3 TRP A 352
THR A 293
TYR A 332
 None
 1.25A 2a3bA-1yiqA:
undetectable		 2a3bA-1yiqA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DPM_A_SAMA300_0
(PROTEIN
(ADENINE-SPECIFIC
METHYLTRANSFERASE
DPNII 1))		 1yiq QUINOHEMOPROTEIN
ALCOHOL
DEHYDROGENASE
(Pseudomonas
putida) 		5 / 12 GLY A 234
GLY A 256
ALA A 177
PHE A 223
PRO A 203
 None
None
PQQ  A 801 (-2.9A)
None
None
 1.10A 2dpmA-1yiqA:
undetectable		 2dpmA-1yiqA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1yiq QUINOHEMOPROTEIN
ALCOHOL
DEHYDROGENASE
(Pseudomonas
putida) 		4 / 7 HIS A 389
THR A 481
TYR A 404
HIS A 408
 None
 1.33A 2eikN-1yiqA:
undetectable
2eikP-1yiqA:
undetectable		 2eikN-1yiqA:
21.21
2eikP-1yiqA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_A_CHDA525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1yiq QUINOHEMOPROTEIN
ALCOHOL
DEHYDROGENASE
(Pseudomonas
putida) 		4 / 6 HIS A 389
THR A 481
TYR A 404
HIS A 408
 None
 1.36A 2eimA-1yiqA:
undetectable
2eimC-1yiqA:
undetectable		 2eimA-1yiqA:
21.21
2eimC-1yiqA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1yiq QUINOHEMOPROTEIN
ALCOHOL
DEHYDROGENASE
(Pseudomonas
putida) 		4 / 6 HIS A 389
THR A 481
TYR A 404
HIS A 408
 None
 1.32A 2einA-1yiqA:
undetectable
2einC-1yiqA:
undetectable		 2einA-1yiqA:
21.21
2einC-1yiqA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I30_A_SALA1100_1
(SERUM ALBUMIN)		 1yiq QUINOHEMOPROTEIN
ALCOHOL
DEHYDROGENASE
(Pseudomonas
putida) 		4 / 6 HIS A 631
PHE A 634
TYR A 665
ARG A 624
 None
HEM  A 901 ( 4.7A)
PGR  A 804 (-4.5A)
PGR  A 805 (-4.2A)
 1.09A 2i30A-1yiqA:
2.2		 2i30A-1yiqA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WQ5_A_MIYA1120_1
(PHOSPHOLIPASE A2,
ACIDIC)		 1yiq QUINOHEMOPROTEIN
ALCOHOL
DEHYDROGENASE
(Pseudomonas
putida) 		4 / 7 LEU A 365
TRP A 299
ALA A 298
GLY A 296
 None
 0.97A 2wq5A-1yiqA:
undetectable		 2wq5A-1yiqA:
10.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_C_X2NC1479_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 1yiq QUINOHEMOPROTEIN
ALCOHOL
DEHYDROGENASE
(Pseudomonas
putida) 		5 / 12 PHE A 634
PHE A 639
ALA A 651
ALA A 653
LEU A 601
 HEM  A 901 ( 4.7A)
None
None
None
None
 1.27A 2x2nC-1yiqA:
undetectable		 2x2nC-1yiqA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_D_X2ND1479_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 1yiq QUINOHEMOPROTEIN
ALCOHOL
DEHYDROGENASE
(Pseudomonas
putida) 		5 / 12 PHE A 634
PHE A 639
ALA A 651
ALA A 653
LEU A 601
 HEM  A 901 ( 4.7A)
None
None
None
None
 1.27A 2x2nD-1yiqA:
undetectable		 2x2nD-1yiqA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X8O_A_OINA1314_1
(CHOLINE-BINDING
PROTEIN F)		 1yiq QUINOHEMOPROTEIN
ALCOHOL
DEHYDROGENASE
(Pseudomonas
putida) 		4 / 5 LYS A 668
ASP A 672
ARG A 624
TYR A 665
 PGR  A 804 (-2.9A)
None
PGR  A 805 (-4.2A)
PGR  A 804 (-4.5A)
 1.39A 2x8oA-1yiqA:
0.0		 2x8oA-1yiqA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1yiq QUINOHEMOPROTEIN
ALCOHOL
DEHYDROGENASE
(Pseudomonas
putida) 		4 / 6 HIS A 389
THR A 481
TYR A 404
HIS A 408
 None
 1.34A 2zxwN-1yiqA:
undetectable
2zxwP-1yiqA:
undetectable		 2zxwN-1yiqA:
21.21
2zxwP-1yiqA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1yiq QUINOHEMOPROTEIN
ALCOHOL
DEHYDROGENASE
(Pseudomonas
putida) 		4 / 7 HIS A 389
THR A 481
TYR A 404
HIS A 408
 None
 1.36A 3abmN-1yiqA:
undetectable
3abmP-1yiqA:
undetectable		 3abmN-1yiqA:
21.21
3abmP-1yiqA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1010_1
(SERUM ALBUMIN)		 1yiq QUINOHEMOPROTEIN
ALCOHOL
DEHYDROGENASE
(Pseudomonas
putida) 		4 / 8 ILE A 667
HIS A 631
PHE A 634
ARG A 624
 None
None
HEM  A 901 ( 4.7A)
PGR  A 805 (-4.2A)
 0.93A 3b9lA-1yiqA:
2.1		 3b9lA-1yiqA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3COT_A_STRA1501_1
(3-OXO-5-BETA-STEROID
4-DEHYDROGENASE)		 1yiq QUINOHEMOPROTEIN
ALCOHOL
DEHYDROGENASE
(Pseudomonas
putida) 		4 / 7 TYR A 372
TYR A 414
TRP A 222
TRP A 373
 None
 1.42A 3cotA-1yiqA:
0.0		 3cotA-1yiqA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GV1_B_BEZB301_0
(DISULFIDE
INTERCHANGE PROTEIN)		 1yiq QUINOHEMOPROTEIN
ALCOHOL
DEHYDROGENASE
(Pseudomonas
putida) 		4 / 6 LYS A  17
ALA A  15
PRO A  19
PRO A  36
 None
 1.15A 3gv1A-1yiqA:
undetectable
3gv1B-1yiqA:
undetectable		 3gv1A-1yiqA:
12.59
3gv1B-1yiqA:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M8P_A_65BA562_0
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H
P51 RT)		 1yiq QUINOHEMOPROTEIN
ALCOHOL
DEHYDROGENASE
(Pseudomonas
putida) 		5 / 11 LEU A 573
VAL A 518
TYR A 559
LEU A 563
GLU A 575
 None
 1.11A 3m8pA-1yiqA:
0.0
3m8pB-1yiqA:
0.0		 3m8pA-1yiqA:
22.21
3m8pB-1yiqA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MED_A_65BA561_0
(P51 REVERSE
TRANSCRIPTASE
P66 REVERSE
TRANSCRIPTASE)		 1yiq QUINOHEMOPROTEIN
ALCOHOL
DEHYDROGENASE
(Pseudomonas
putida) 		6 / 12 LEU A 573
VAL A 518
TYR A 559
GLY A 496
LEU A 563
GLU A 575
 None
 1.32A 3medA-1yiqA:
undetectable
3medB-1yiqA:
undetectable		 3medA-1yiqA:
21.48
3medB-1yiqA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_A_1N1A2000_1
(P38A)		 1yiq QUINOHEMOPROTEIN
ALCOHOL
DEHYDROGENASE
(Pseudomonas
putida) 		5 / 12 MET A 307
VAL A 403
ILE A 405
ILE A 277
ALA A 241
 None
 0.95A 3ohtA-1yiqA:
undetectable
3ohtB-1yiqA:
undetectable		 3ohtA-1yiqA:
21.41
3ohtB-1yiqA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHN_A_ACTA108_0
(PROTEIN P-30)		 1yiq QUINOHEMOPROTEIN
ALCOHOL
DEHYDROGENASE
(Pseudomonas
putida) 		3 / 3 THR A  25
SER A  24
ARG A 164
 None
 0.71A 3phnA-1yiqA:
undetectable		 3phnA-1yiqA:
8.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SJ0_X_DXCX75_0
(CYTOCHROME C7)		 1yiq QUINOHEMOPROTEIN
ALCOHOL
DEHYDROGENASE
(Pseudomonas
putida) 		4 / 7 ILE A 277
PHE A 273
MET A 215
GLY A 214
 None
 1.23A 3sj0X-1yiqA:
undetectable		 3sj0X-1yiqA:
7.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_C_SAMC300_0
(PUTATIVE
METHYLTRANSFERASE)		 1yiq QUINOHEMOPROTEIN
ALCOHOL
DEHYDROGENASE
(Pseudomonas
putida) 		5 / 12 GLY A 234
GLY A 232
SER A 275
ALA A 177
ASN A 255
 None
None
None
PQQ  A 801 (-2.9A)
CA  A 802 ( 3.0A)
 1.38A 3t7sC-1yiqA:
undetectable		 3t7sC-1yiqA:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U88_A_CHDA611_0
(MENIN)		 1yiq QUINOHEMOPROTEIN
ALCOHOL
DEHYDROGENASE
(Pseudomonas
putida) 		3 / 3 SER A 343
PHE A 331
LYS A 345
 None
 0.98A 3u88A-1yiqA:
undetectable		 3u88A-1yiqA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AGA_A_ACTA1131_0
(LYSOZYME C)		 1yiq QUINOHEMOPROTEIN
ALCOHOL
DEHYDROGENASE
(Pseudomonas
putida) 		3 / 3 ASN A 247
ASP A 283
ASN A 167
 None
 0.42A 4agaA-1yiqA:
undetectable		 4agaA-1yiqA:
11.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CP3_B_RBTB1129_1
(B-CELL LYMPHOMA 6
PROTEIN)		 1yiq QUINOHEMOPROTEIN
ALCOHOL
DEHYDROGENASE
(Pseudomonas
putida) 		5 / 7 LEU A 666
ARG A 669
GLY A 604
TYR A 602
SER A 607
 None
 1.25A 4cp3A-1yiqA:
undetectable
4cp3B-1yiqA:
undetectable		 4cp3A-1yiqA:
10.74
4cp3B-1yiqA:
10.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_A_SAMA301_1
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 1yiq QUINOHEMOPROTEIN
ALCOHOL
DEHYDROGENASE
(Pseudomonas
putida) 		3 / 3 TYR A 525
THR A 534
GLU A 530
 None
 0.73A 4df3A-1yiqA:
undetectable		 4df3A-1yiqA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_B_SAMB301_1
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 1yiq QUINOHEMOPROTEIN
ALCOHOL
DEHYDROGENASE
(Pseudomonas
putida) 		3 / 3 TYR A 525
THR A 534
GLU A 530
 None
 0.73A 4df3B-1yiqA:
undetectable		 4df3B-1yiqA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IB4_A_ERMA2001_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 1yiq QUINOHEMOPROTEIN
ALCOHOL
DEHYDROGENASE
(Pseudomonas
putida) 		4 / 7 ASP A 111
THR A 160
GLN A 561
LEU A  56
 None
PQQ  A 801 (-2.6A)
None
None
 1.09A 4ib4A-1yiqA:
undetectable		 4ib4A-1yiqA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_B_ADNB501_2
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 1yiq QUINOHEMOPROTEIN
ALCOHOL
DEHYDROGENASE
(Pseudomonas
putida) 		3 / 3 PRO A 313
LEU A 312
GLN A 465
 None
 0.62A 4pevB-1yiqA:
undetectable		 4pevB-1yiqA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4POO_A_SAMA301_0
(PUTATIVE RNA
METHYLASE)		 1yiq QUINOHEMOPROTEIN
ALCOHOL
DEHYDROGENASE
(Pseudomonas
putida) 		5 / 12 THR A 545
GLY A 617
ILE A 612
SER A 607
LEU A 552
 None
PGR  A 805 ( 4.9A)
None
None
PGR  A 805 (-4.6A)
 1.27A 4pooA-1yiqA:
undetectable		 4pooA-1yiqA:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5Q_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 1yiq QUINOHEMOPROTEIN
ALCOHOL
DEHYDROGENASE
(Pseudomonas
putida) 		4 / 6 ASP A 297
ALA A 303
THR A 294
TYR A 301
 None
 1.33A 4w5qA-1yiqA:
undetectable		 4w5qA-1yiqA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5R_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 1yiq QUINOHEMOPROTEIN
ALCOHOL
DEHYDROGENASE
(Pseudomonas
putida) 		4 / 6 ASP A 297
ALA A 303
THR A 294
TYR A 301
 None
 1.33A 4w5rA-1yiqA:
undetectable		 4w5rA-1yiqA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5T_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 1yiq QUINOHEMOPROTEIN
ALCOHOL
DEHYDROGENASE
(Pseudomonas
putida) 		4 / 6 ASP A 297
ALA A 303
THR A 294
TYR A 301
 None
 1.30A 4w5tA-1yiqA:
undetectable		 4w5tA-1yiqA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WS1_A_URFA301_1
(URACIL-DNA
GLYCOSYLASE)		 1yiq QUINOHEMOPROTEIN
ALCOHOL
DEHYDROGENASE
(Pseudomonas
putida) 		4 / 8 GLY A 437
TYR A 430
PHE A 546
SER A 607
 None
 1.03A 4ws1A-1yiqA:
undetectable		 4ws1A-1yiqA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA906_0
(PROTEIN ARGONAUTE-2)		 1yiq QUINOHEMOPROTEIN
ALCOHOL
DEHYDROGENASE
(Pseudomonas
putida) 		4 / 6 ASP A 297
ALA A 303
THR A 294
TYR A 301
 None
 1.30A 4z4cA-1yiqA:
undetectable		 4z4cA-1yiqA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4F_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 1yiq QUINOHEMOPROTEIN
ALCOHOL
DEHYDROGENASE
(Pseudomonas
putida) 		4 / 6 ASP A 297
ALA A 303
THR A 294
TYR A 301
 None
 1.30A 4z4fA-1yiqA:
undetectable		 4z4fA-1yiqA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4G_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 1yiq QUINOHEMOPROTEIN
ALCOHOL
DEHYDROGENASE
(Pseudomonas
putida) 		4 / 5 ASP A 297
ALA A 303
THR A 294
TYR A 301
 None
 1.31A 4z4gA-1yiqA:
0.0		 4z4gA-1yiqA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4I_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 1yiq QUINOHEMOPROTEIN
ALCOHOL
DEHYDROGENASE
(Pseudomonas
putida) 		4 / 6 ASP A 297
ALA A 303
THR A 294
TYR A 301
 None
 1.29A 4z4iA-1yiqA:
undetectable		 4z4iA-1yiqA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1yiq QUINOHEMOPROTEIN
ALCOHOL
DEHYDROGENASE
(Pseudomonas
putida) 		4 / 7 HIS A 389
THR A 481
TYR A 404
HIS A 408
 None
 1.35A 5b1aN-1yiqA:
undetectable
5b1aP-1yiqA:
undetectable		 5b1aN-1yiqA:
21.21
5b1aP-1yiqA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1yiq QUINOHEMOPROTEIN
ALCOHOL
DEHYDROGENASE
(Pseudomonas
putida) 		4 / 7 HIS A 389
THR A 481
TYR A 404
HIS A 408
 None
 1.35A 5b3sN-1yiqA:
undetectable
5b3sP-1yiqA:
undetectable		 5b3sN-1yiqA:
21.21
5b3sP-1yiqA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_A_PAUA602_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 1yiq QUINOHEMOPROTEIN
ALCOHOL
DEHYDROGENASE
(Pseudomonas
putida) 		4 / 7 GLY A 517
SER A 493
GLY A 479
ALA A 537
 None
 0.95A 5e26A-1yiqA:
undetectable
5e26B-1yiqA:
undetectable		 5e26A-1yiqA:
20.67
5e26B-1yiqA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESL_A_1YNA701_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1yiq QUINOHEMOPROTEIN
ALCOHOL
DEHYDROGENASE
(Pseudomonas
putida) 		4 / 5 ALA A 218
PRO A 295
GLY A 346
LEU A 341
 None
 0.84A 5eslA-1yiqA:
undetectable		 5eslA-1yiqA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F9Z_A_HFGA702_0
(AMINOACYL-TRNA
SYNTHETASE)		 1yiq QUINOHEMOPROTEIN
ALCOHOL
DEHYDROGENASE
(Pseudomonas
putida) 		5 / 12 GLY A 540
GLU A  63
VAL A  62
PRO A  78
GLY A 106
 None
PQQ  A 801 (-2.5A)
None
None
HEM  A 901 (-3.3A)
 1.02A 5f9zA-1yiqA:
undetectable		 5f9zA-1yiqA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1yiq QUINOHEMOPROTEIN
ALCOHOL
DEHYDROGENASE
(Pseudomonas
putida) 		4 / 7 HIS A 389
THR A 481
TYR A 404
HIS A 408
 None
 1.36A 5iy5A-1yiqA:
undetectable
5iy5C-1yiqA:
undetectable		 5iy5A-1yiqA:
21.21
5iy5C-1yiqA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_C_SAMC501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 1yiq QUINOHEMOPROTEIN
ALCOHOL
DEHYDROGENASE
(Pseudomonas
putida) 		4 / 7 LEU A 447
GLY A 445
GLY A 442
ALA A 450
 None
 0.79A 5o96C-1yiqA:
undetectable		 5o96C-1yiqA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA307_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 1yiq QUINOHEMOPROTEIN
ALCOHOL
DEHYDROGENASE
(Pseudomonas
putida) 		4 / 5 ASP A 581
PRO A 628
GLU A 629
THR A 627
 None
 1.35A 5uxcA-1yiqA:
undetectable		 5uxcA-1yiqA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0V_A_8QPA613_1
(SERUM ALBUMIN)		 1yiq QUINOHEMOPROTEIN
ALCOHOL
DEHYDROGENASE
(Pseudomonas
putida) 		4 / 8 ARG A  60
PHE A 179
THR A 160
GLY A 106
 HEM  A 901 (-3.9A)
None
PQQ  A 801 (-2.6A)
HEM  A 901 (-3.3A)
 0.95A 5v0vA-1yiqA:
2.2		 5v0vA-1yiqA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1yiq QUINOHEMOPROTEIN
ALCOHOL
DEHYDROGENASE
(Pseudomonas
putida) 		4 / 6 HIS A 389
THR A 481
TYR A 404
HIS A 408
 None
 1.33A 5x19N-1yiqA:
undetectable
5x19P-1yiqA:
undetectable		 5x19N-1yiqA:
21.21
5x19P-1yiqA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1yiq QUINOHEMOPROTEIN
ALCOHOL
DEHYDROGENASE
(Pseudomonas
putida) 		4 / 7 HIS A 389
THR A 481
TYR A 404
HIS A 408
 None
 1.32A 5x1fN-1yiqA:
undetectable
5x1fP-1yiqA:
undetectable		 5x1fN-1yiqA:
21.21
5x1fP-1yiqA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1yiq QUINOHEMOPROTEIN
ALCOHOL
DEHYDROGENASE
(Pseudomonas
putida) 		4 / 7 HIS A 389
THR A 481
TYR A 404
HIS A 408
 None
 1.33A 5zcqN-1yiqA:
undetectable
5zcqP-1yiqA:
undetectable		 5zcqN-1yiqA:
21.21
5zcqP-1yiqA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRF_D_EVPD101_1
()		 1yiq QUINOHEMOPROTEIN
ALCOHOL
DEHYDROGENASE
(Pseudomonas
putida) 		4 / 5 GLY A 339
ASP A 335
ARG A 336
GLN A 324
 None
 1.47A 5zrfB-1yiqA:
undetectable		 5zrfB-1yiqA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_B_ZOTB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 1yiq QUINOHEMOPROTEIN
ALCOHOL
DEHYDROGENASE
(Pseudomonas
putida) 		6 / 12 VAL A 170
LEU A 133
VAL A 147
GLY A 193
TRP A 197
VAL A 185
 None
 1.31A 6a94B-1yiqA:
undetectable		 6a94B-1yiqA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_C_CHDC303_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1yiq QUINOHEMOPROTEIN
ALCOHOL
DEHYDROGENASE
(Pseudomonas
putida) 		4 / 6 HIS A 389
THR A 481
TYR A 404
HIS A 408
 None
 1.37A 6nmpA-1yiqA:
0.0
6nmpC-1yiqA:
0.0		 6nmpA-1yiqA:
21.21
6nmpC-1yiqA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_P_CHDP302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1yiq QUINOHEMOPROTEIN
ALCOHOL
DEHYDROGENASE
(Pseudomonas
putida) 		4 / 7 HIS A 389
THR A 481
TYR A 404
HIS A 408
 None
 1.37A 6nmpN-1yiqA:
undetectable
6nmpP-1yiqA:
undetectable		 6nmpN-1yiqA:
21.21
6nmpP-1yiqA:
18.12