SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1yir'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E73_M_ASCM995_0
(MYROSINASE MA1)		 1yir NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE 2
(Pseudomonas
aeruginosa) 		4 / 6 GLN A  61
ILE A  12
ARG A 183
PHE A  97
 None
 1.41A 1e73M-1yirA:
3.5		 1e73M-1yirA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_A_HLTA4002_1
(SERUM ALBUMIN)		 1yir NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE 2
(Pseudomonas
aeruginosa) 		4 / 4 ARG A 151
ALA A 150
ALA A   7
GLU A   5
 None
 0.64A 1e7bA-1yirA:
undetectable		 1e7bA-1yirA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_B_HLTB4002_1
(SERUM ALBUMIN)		 1yir NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE 2
(Pseudomonas
aeruginosa) 		4 / 4 ARG A 151
ALA A 150
ALA A   7
GLU A   5
 None
 0.65A 1e7bB-1yirA:
undetectable		 1e7bB-1yirA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4002_1
(SERUM ALBUMIN)		 1yir NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE 2
(Pseudomonas
aeruginosa) 		4 / 5 ARG A 151
ALA A 150
ALA A   7
GLU A   5
 None
 0.67A 1e7cA-1yirA:
undetectable		 1e7cA-1yirA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_A_CHDA1501_0
(FERROCHELATASE)		 1yir NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE 2
(Pseudomonas
aeruginosa) 		5 / 12 LEU A  92
PHE A  88
LEU A  78
ILE A 123
PRO A 220
 None
 1.10A 1hrkA-1yirA:
undetectable		 1hrkA-1yirA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_B_CHDB2501_0
(FERROCHELATASE)		 1yir NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE 2
(Pseudomonas
aeruginosa) 		5 / 12 LEU A  92
PHE A  88
LEU A  78
ILE A 123
PRO A 220
 None
 1.07A 1hrkB-1yirA:
undetectable		 1hrkB-1yirA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ISM_B_NCAB305_0
(BONE MARROW STROMAL
CELL ANTIGEN 1)		 1yir NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE 2
(Pseudomonas
aeruginosa) 		4 / 7 HIS A 226
SER A 290
ASP A 289
PHE A 271
 SO4  A2001 (-3.7A)
None
SO4  A2001 ( 4.2A)
None
 1.15A 1ismB-1yirA:
undetectable		 1ismB-1yirA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XF1_A_ACTA1107_0
(C5A PEPTIDASE)		 1yir NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE 2
(Pseudomonas
aeruginosa) 		4 / 5 LEU A 324
HIS A 347
ILE A 344
PHE A 342
 None
 0.94A 1xf1A-1yirA:
1.6		 1xf1A-1yirA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXG_A_IBPA2002_1
(SERUM ALBUMIN)		 1yir NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE 2
(Pseudomonas
aeruginosa) 		4 / 8 ARG A 151
ALA A 150
ALA A   7
GLU A   5
 None
 0.65A 2bxgA-1yirA:
undetectable		 2bxgA-1yirA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E5D_A_NCAA1501_0
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 1yir NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE 2
(Pseudomonas
aeruginosa) 		5 / 7 PHE A 178
ARG A 181
ARG A 287
ASP A  20
TYR A  22
 None
SO4  A2001 (-3.5A)
SO4  A2001 (-3.1A)
None
SO4  A2001 (-4.6A)
 0.71A 2e5dA-1yirA:
5.1
2e5dB-1yirA:
6.1		 2e5dA-1yirA:
23.54
2e5dB-1yirA:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E5D_B_NCAB1502_0
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 1yir NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE 2
(Pseudomonas
aeruginosa) 		5 / 7 ASP A  20
TYR A  22
PHE A 178
ARG A 181
ARG A 287
 None
SO4  A2001 (-4.6A)
None
SO4  A2001 (-3.5A)
SO4  A2001 (-3.1A)
 0.64A 2e5dA-1yirA:
5.1
2e5dB-1yirA:
6.1		 2e5dA-1yirA:
23.54
2e5dB-1yirA:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F7F_A_NIOA601_1
(NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE, PUTATIVE)		 1yir NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE 2
(Pseudomonas
aeruginosa) 		6 / 6 PHE A 178
ARG A 181
SER A 208
GLY A 222
THR A 223
ARG A 287
 None
SO4  A2001 (-3.5A)
None
None
None
SO4  A2001 (-3.1A)
 0.61A 2f7fA-1yirA:
10.2		 2f7fA-1yirA:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_A_CHDA701_0
(FERROCHELATASE)		 1yir NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE 2
(Pseudomonas
aeruginosa) 		5 / 12 LEU A  92
PHE A  88
LEU A  78
ILE A 123
PRO A 220
 None
 1.12A 2hrcA-1yirA:
undetectable		 2hrcA-1yirA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_B_CHDB1605_0
(FERROCHELATASE)		 1yir NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE 2
(Pseudomonas
aeruginosa) 		5 / 12 LEU A  92
PHE A  88
LEU A  78
ILE A 123
PRO A 220
 None
 1.20A 2hrcB-1yirA:
undetectable		 2hrcB-1yirA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_B_CHDB501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1yir NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE 2
(Pseudomonas
aeruginosa) 		5 / 12 LEU A  92
PHE A  88
LEU A  78
ILE A 123
PRO A 220
 None
 0.96A 2pnjB-1yirA:
undetectable		 2pnjB-1yirA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_A_CHDA501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1yir NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE 2
(Pseudomonas
aeruginosa) 		5 / 12 LEU A  92
PHE A  88
LEU A  78
ILE A 123
PRO A 220
 None
 1.04A 2po5A-1yirA:
undetectable		 2po5A-1yirA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_A_CHDA501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1yir NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE 2
(Pseudomonas
aeruginosa) 		5 / 12 LEU A  92
PHE A  88
LEU A  78
ILE A 123
PRO A 220
 None
 1.01A 2po7A-1yirA:
undetectable		 2po7A-1yirA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_B_CHDB501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1yir NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE 2
(Pseudomonas
aeruginosa) 		5 / 12 LEU A  92
PHE A  88
LEU A  78
ILE A 123
PRO A 220
 None
 1.03A 2po7B-1yirA:
undetectable		 2po7B-1yirA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGO_A_PCFA1213_1
(WNT INHIBITORY
FACTOR 1)		 1yir NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE 2
(Pseudomonas
aeruginosa) 		4 / 6 LEU A  78
ILE A  81
PRO A 220
VAL A  39
 None
 1.16A 2ygoA-1yirA:
undetectable		 2ygoA-1yirA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AMU_A_AG2A422_1
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 1yir NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE 2
(Pseudomonas
aeruginosa) 		4 / 5 GLU A  49
ASN A 138
VAL A 355
ARG A 141
 None
 1.46A 3amuA-1yirA:
0.0		 3amuA-1yirA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_B_CHDB6_0
(FERROCHELATASE)		 1yir NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE 2
(Pseudomonas
aeruginosa) 		5 / 12 LEU A  92
PHE A  88
LEU A  78
ILE A 123
PRO A 220
 None
 1.05A 3aqiB-1yirA:
0.0		 3aqiB-1yirA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_C_SALC404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 1yir NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE 2
(Pseudomonas
aeruginosa) 		4 / 7 ALA A  57
PRO A  56
TYR A  54
ARG A  52
 None
 1.10A 3twpC-1yirA:
undetectable		 3twpC-1yirA:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1yir NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE 2
(Pseudomonas
aeruginosa) 		5 / 12 LEU A  92
PHE A  88
LEU A  78
ILE A 123
PRO A 220
 None
 1.07A 3w1wA-1yirA:
undetectable		 3w1wA-1yirA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1yir NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE 2
(Pseudomonas
aeruginosa) 		5 / 12 LEU A  92
PHE A  88
LEU A  78
ILE A 123
PRO A 220
 None
 1.06A 3w1wB-1yirA:
undetectable		 3w1wB-1yirA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRK_D_CAMD502_0
(CAMPHOR
5-MONOOXYGENASE)		 1yir NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE 2
(Pseudomonas
aeruginosa) 		4 / 5 PHE A 204
GLY A 345
THR A 349
VAL A 192
 None
SO4  A2002 (-3.4A)
None
None
 1.00A 3wrkD-1yirA:
undetectable		 3wrkD-1yirA:
25.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WXO_A_NIZA802_1
(CATALASE-PEROXIDASE)		 1yir NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE 2
(Pseudomonas
aeruginosa) 		4 / 8 LEU A  84
ILE A  89
GLY A  93
ILE A  70
 None
 0.84A 3wxoA-1yirA:
0.1		 3wxoA-1yirA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_A_20JA601_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 1yir NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE 2
(Pseudomonas
aeruginosa) 		4 / 8 PHE A 178
ARG A 181
ARG A 287
TYR A  22
 None
SO4  A2001 (-3.5A)
SO4  A2001 (-3.1A)
SO4  A2001 (-4.6A)
 0.43A 4lv9A-1yirA:
6.4
4lv9B-1yirA:
4.5		 4lv9A-1yirA:
24.62
4lv9B-1yirA:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_K_HCYK900_1
(GLUCOCORTICOID
RECEPTOR)		 1yir NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE 2
(Pseudomonas
aeruginosa) 		5 / 12 GLY A 222
TRP A 250
ARG A 181
ILE A  81
PHE A  83
 None
None
SO4  A2001 (-3.5A)
None
None
 1.50A 4p6xK-1yirA:
undetectable		 4p6xK-1yirA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1yir NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE 2
(Pseudomonas
aeruginosa) 		4 / 5 LEU A  75
PHE A  77
LEU A  92
PHE A  88
 None
 1.25A 5iy5P-1yirA:
undetectable
5iy5W-1yirA:
undetectable		 5iy5P-1yirA:
21.34
5iy5W-1yirA:
9.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_B_BO2B305_1
(PROTEASOME SUBUNIT
BETA TYPE-6)		 1yir NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE 2
(Pseudomonas
aeruginosa) 		5 / 12 THR A 346
THR A 349
ARG A 287
GLY A 343
MET A 175
 SO4  A2002 (-3.6A)
None
SO4  A2001 (-3.1A)
None
None
 1.40A 5lf3b-1yirA:
undetectable		 5lf3b-1yirA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_N_BO2N304_1
(PROTEASOME SUBUNIT
BETA TYPE-6)		 1yir NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE 2
(Pseudomonas
aeruginosa) 		5 / 12 THR A 346
THR A 349
ARG A 287
GLY A 343
MET A 175
 SO4  A2002 (-3.6A)
None
SO4  A2001 (-3.1A)
None
None
 1.41A 5lf3N-1yirA:
undetectable		 5lf3N-1yirA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TDM_A_ADNA904_1
(ATP-CITRATE SYNTHASE)		 1yir NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE 2
(Pseudomonas
aeruginosa) 		4 / 4 THR A 268
ASP A 269
ARG A 273
LEU A 272
 None
 1.35A 5tdmA-1yirA:
0.9		 5tdmA-1yirA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1yir NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE 2
(Pseudomonas
aeruginosa) 		4 / 5 LEU A  75
PHE A  77
LEU A  92
PHE A  88
 None
 1.19A 5x1fC-1yirA:
undetectable
5x1fJ-1yirA:
undetectable		 5x1fC-1yirA:
21.09
5x1fJ-1yirA:
10.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_C_CHDC308_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT VIIA-HEART)		 1yir NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE 2
(Pseudomonas
aeruginosa) 		4 / 5 LEU A  75
PHE A  77
LEU A  92
PHE A  88
 None
 1.22A 5xdxC-1yirA:
undetectable
5xdxJ-1yirA:
undetectable		 5xdxC-1yirA:
21.34
5xdxJ-1yirA:
10.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT VIIA-HEART)		 1yir NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE 2
(Pseudomonas
aeruginosa) 		4 / 5 LEU A  75
PHE A  77
LEU A  92
PHE A  88
 None
 1.23A 5xdxP-1yirA:
undetectable
5xdxW-1yirA:
undetectable		 5xdxP-1yirA:
21.34
5xdxW-1yirA:
10.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZHM_B_SAMB301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 1yir NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE 2
(Pseudomonas
aeruginosa) 		4 / 4 ARG A 182
SER A 319
ASP A 289
HIS A 226
 SO4  A2002 ( 4.8A)
None
SO4  A2001 ( 4.2A)
SO4  A2001 (-3.7A)
 1.29A 5zhmA-1yirA:
0.0		 5zhmA-1yirA:
22.22