SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1yis'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NH8_A_HISA289_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 1yis ADENYLOSUCCINATE
LYASE
(Caenorhabditis
elegans) 		4 / 5 ASP A 136
LEU A 467
ALA A 139
LEU A 143
 None
 1.10A 1nh8A-1yisA:
undetectable		 1nh8A-1yisA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VPT_A_SAMA400_1
(VP39)		 1yis ADENYLOSUCCINATE
LYASE
(Caenorhabditis
elegans) 		3 / 3 ASP A 136
ARG A 137
ASP A 468
 None
 0.88A 1vptA-1yisA:
undetectable		 1vptA-1yisA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOW_A_THAA400_1
(HISTAMINE
N-METHYLTRANSFERASE)		 1yis ADENYLOSUCCINATE
LYASE
(Caenorhabditis
elegans) 		4 / 7 PHE A 454
GLU A 458
GLN A 180
GLU A 174
 None
 1.41A 2aowA-1yisA:
undetectable		 2aowA-1yisA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA501_1
(CYTOCHROME P450 2B4)		 1yis ADENYLOSUCCINATE
LYASE
(Caenorhabditis
elegans) 		4 / 7 LEU A 143
GLY A 165
THR A 163
ILE A 441
 None
 1.06A 2bdmA-1yisA:
undetectable		 2bdmA-1yisA:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E23_A_SAMA221_0
(UNCHARACTERIZED
PROTEIN RPA2492)		 1yis ADENYLOSUCCINATE
LYASE
(Caenorhabditis
elegans) 		5 / 12 LEU A 207
GLY A 196
GLY A 105
SER A 203
LEU A 104
 None
SO4  A1001 (-2.8A)
None
None
None
 1.17A 3e23A-1yisA:
undetectable		 3e23A-1yisA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_C_ROFC903_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 1yis ADENYLOSUCCINATE
LYASE
(Caenorhabditis
elegans) 		3 / 3 SER A 245
GLN A 246
PHE A 249
 None
 0.58A 3g4lC-1yisA:
undetectable		 3g4lC-1yisA:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VHU_A_SNLA1001_2
(MINERALOCORTICOID
RECEPTOR)		 1yis ADENYLOSUCCINATE
LYASE
(Caenorhabditis
elegans) 		4 / 5 LEU A 347
LEU A 348
LEU A 251
SER A 252
 None
 0.92A 3vhuA-1yisA:
undetectable		 3vhuA-1yisA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_A_LNLA701_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1yis ADENYLOSUCCINATE
LYASE
(Caenorhabditis
elegans) 		4 / 5 ARG A 153
VAL A 162
LEU A 161
SER A 160
 None
 1.32A 4e1gA-1yisA:
undetectable		 4e1gA-1yisA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_D_SAMD401_1
(METHYLTRANSFERASE
NSUN4)		 1yis ADENYLOSUCCINATE
LYASE
(Caenorhabditis
elegans) 		3 / 3 ASP A 136
ARG A 137
ASP A 468
 None
 0.86A 4fp9D-1yisA:
undetectable		 4fp9D-1yisA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FZV_A_SAMA401_1
(PUTATIVE
METHYLTRANSFERASE
NSUN4)		 1yis ADENYLOSUCCINATE
LYASE
(Caenorhabditis
elegans) 		3 / 3 ASP A 136
ARG A 137
ASP A 468
 None
 0.85A 4fzvA-1yisA:
undetectable		 4fzvA-1yisA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MX0_A_BCZA513_1
(NEURAMINIDASE)		 1yis ADENYLOSUCCINATE
LYASE
(Caenorhabditis
elegans) 		3 / 3 ARG A 241
ASP A 116
ARG A 325
 None
 0.85A 4mx0A-1yisA:
undetectable		 4mx0A-1yisA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECL_A_ILEA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 1yis ADENYLOSUCCINATE
LYASE
(Caenorhabditis
elegans) 		4 / 6 ALA A 106
THR A 107
VAL A  84
HIS A 103
 SO4  A1001 (-2.7A)
SO4  A1001 (-3.4A)
None
None
 1.05A 5eclA-1yisA:
undetectable		 5eclA-1yisA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1yis ADENYLOSUCCINATE
LYASE
(Caenorhabditis
elegans) 		4 / 4 LEU A 351
ARG A 137
ILE A 354
PHE A 355
 None
 1.17A 5kirB-1yisA:
undetectable		 5kirB-1yisA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA307_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 1yis ADENYLOSUCCINATE
LYASE
(Caenorhabditis
elegans) 		4 / 4 LEU A 351
LEU A 348
SER A 304
ALA A 344
 None
 0.99A 5uunA-1yisA:
undetectable		 5uunA-1yisA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F32_B_ACTB602_0
(AMINE OXIDASE LKCE)		 1yis ADENYLOSUCCINATE
LYASE
(Caenorhabditis
elegans) 		4 / 6 ASN A 145
VAL A 148
VAL A 365
THR A 362
 None
 1.27A 6f32B-1yisA:
undetectable		 6f32B-1yisA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G2P_A_TRPA502_0
(FLAVIN-DEPENDENT
L-TRYPTOPHAN OXIDASE
VIOA)		 1yis ADENYLOSUCCINATE
LYASE
(Caenorhabditis
elegans) 		4 / 7 ARG A 333
TYR A 120
LEU A 251
VAL A 248
 None
 1.38A 6g2pA-1yisA:
undetectable		 6g2pA-1yisA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NM4_A_SAMA402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
PRDM9)		 1yis ADENYLOSUCCINATE
LYASE
(Caenorhabditis
elegans) 		4 / 7 ALA A 106
GLY A 105
GLY A 199
CYH A 109
 SO4  A1001 (-2.7A)
None
None
None
 0.86A 6nm4A-1yisA:
undetectable		 6nm4A-1yisA:
17.83