SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1yix'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E9Y_B_HAEB800_1
(UREASE SUBUNIT BETA)		 1yix DEOXYRIBONUCLEASE
YCFH
(Escherichia
coli) 		4 / 5 HIS A   7
HIS A  67
HIS A 130
ASP A 205
 ZN  A 601 (-3.3A)
None
ZN  A 604 (-3.3A)
ZN  A 601 (-2.8A)
 0.79A 1e9yB-1yixA:
15.7		 1e9yB-1yixA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FWE_C_HAEC989_1
(UREASE)		 1yix DEOXYRIBONUCLEASE
YCFH
(Escherichia
coli) 		5 / 6 HIS A   7
HIS A   9
HIS A  67
HIS A 130
ASP A 205
 ZN  A 601 (-3.3A)
ZN  A 601 (-3.2A)
None
ZN  A 604 (-3.3A)
ZN  A 601 (-2.8A)
 0.76A 1fweC-1yixA:
15.8		 1fweC-1yixA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ITU_A_CILA451_1
(RENAL DIPEPTIDASE)		 1yix DEOXYRIBONUCLEASE
YCFH
(Escherichia
coli) 		5 / 12 GLU A  94
HIS A  67
HIS A 130
HIS A 155
ASP A 205
 ZN  A 604 ( 2.5A)
None
ZN  A 604 (-3.3A)
ZN  A 604 ( 3.2A)
ZN  A 601 (-2.8A)
 0.99A 1ituA-1yixA:
10.0		 1ituA-1yixA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ITU_A_CILA451_1
(RENAL DIPEPTIDASE)		 1yix DEOXYRIBONUCLEASE
YCFH
(Escherichia
coli) 		5 / 12 HIS A  67
HIS A 130
HIS A 155
ASP A 205
PRO A 207
 None
ZN  A 604 (-3.3A)
ZN  A 604 ( 3.2A)
ZN  A 601 (-2.8A)
None
 1.43A 1ituA-1yixA:
10.0		 1ituA-1yixA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ITU_B_CILB452_1
(RENAL DIPEPTIDASE)		 1yix DEOXYRIBONUCLEASE
YCFH
(Escherichia
coli) 		5 / 12 GLU A  94
HIS A  67
HIS A 130
HIS A 155
ASP A 205
 ZN  A 604 ( 2.5A)
None
ZN  A 604 (-3.3A)
ZN  A 604 ( 3.2A)
ZN  A 601 (-2.8A)
 1.00A 1ituB-1yixA:
14.7		 1ituB-1yixA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ITU_B_CILB452_1
(RENAL DIPEPTIDASE)		 1yix DEOXYRIBONUCLEASE
YCFH
(Escherichia
coli) 		5 / 12 HIS A  67
HIS A 130
HIS A 155
ASP A 205
PRO A 207
 None
ZN  A 604 (-3.3A)
ZN  A 604 ( 3.2A)
ZN  A 601 (-2.8A)
None
 1.44A 1ituB-1yixA:
14.7		 1ituB-1yixA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_A_RIMA199_1
(MATRIX PROTEIN 2)		 1yix DEOXYRIBONUCLEASE
YCFH
(Escherichia
coli) 		4 / 6 LEU A 200
LEU A 197
ILE A 174
ARG A 199
 None
 0.99A 2rlfA-1yixA:
undetectable
2rlfB-1yixA:
undetectable		 2rlfA-1yixA:
11.49
2rlfB-1yixA:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YQZ_A_SAMA301_0
(HYPOTHETICAL PROTEIN
TTHA0223)		 1yix DEOXYRIBONUCLEASE
YCFH
(Escherichia
coli) 		5 / 12 ALA A  29
VAL A  40
HIS A   9
LEU A  10
LEU A  13
 None
None
ZN  A 601 (-3.2A)
None
None
 0.98A 2yqzA-1yixA:
undetectable		 2yqzA-1yixA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H5G_B_LEIB16_0
(COIL SER L16D-PEN)		 1yix DEOXYRIBONUCLEASE
YCFH
(Escherichia
coli) 		4 / 5 LEU A 197
GLN A 244
LEU A 242
GLU A 241
 None
 1.04A 3h5gA-1yixA:
undetectable
3h5gB-1yixA:
undetectable		 3h5gA-1yixA:
9.76
3h5gB-1yixA:
9.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB1_A_SAMA1101_0
(STRUCTURAL PROTEIN
VP3)		 1yix DEOXYRIBONUCLEASE
YCFH
(Escherichia
coli) 		5 / 12 ILE A 128
GLY A  93
ALA A  84
ALA A  41
PRO A  68
 None
 0.88A 3jb1A-1yixA:
undetectable		 3jb1A-1yixA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1102_0
(STRUCTURAL PROTEIN
VP3)		 1yix DEOXYRIBONUCLEASE
YCFH
(Escherichia
coli) 		5 / 12 ILE A 128
GLY A  93
ALA A  84
ALA A  41
PRO A  68
 None
 0.88A 3jb2A-1yixA:
undetectable		 3jb2A-1yixA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB3_A_SAMA1102_0
(STRUCTURAL PROTEIN
VP3)		 1yix DEOXYRIBONUCLEASE
YCFH
(Escherichia
coli) 		5 / 12 ILE A 128
GLY A  93
ALA A  84
ALA A  41
PRO A  68
 None
 0.80A 3jb3A-1yixA:
undetectable		 3jb3A-1yixA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVR_A_URFA2001_1
(URIDINE
PHOSPHORYLASE)		 1yix DEOXYRIBONUCLEASE
YCFH
(Escherichia
coli) 		5 / 10 GLY A 165
GLU A 162
LEU A 167
LEU A 168
ILE A 174
 None
 0.83A 3kvrA-1yixA:
undetectable		 3kvrA-1yixA:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVR_A_URFA2001_1
(URIDINE
PHOSPHORYLASE)		 1yix DEOXYRIBONUCLEASE
YCFH
(Escherichia
coli) 		5 / 10 THR A 163
GLY A 165
LEU A 167
LEU A 168
ILE A 174
 None
 1.17A 3kvrA-1yixA:
undetectable		 3kvrA-1yixA:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVR_B_URFB2011_1
(URIDINE
PHOSPHORYLASE)		 1yix DEOXYRIBONUCLEASE
YCFH
(Escherichia
coli) 		5 / 10 GLY A 165
GLU A 162
LEU A 167
LEU A 168
ILE A 174
 None
 0.92A 3kvrB-1yixA:
undetectable		 3kvrB-1yixA:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVR_B_URFB2011_1
(URIDINE
PHOSPHORYLASE)		 1yix DEOXYRIBONUCLEASE
YCFH
(Escherichia
coli) 		5 / 10 THR A 163
GLY A 165
LEU A 167
LEU A 168
ILE A 174
 None
 1.26A 3kvrB-1yixA:
undetectable		 3kvrB-1yixA:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_A_URFA400_1
(URIDINE
PHOSPHORYLASE 1)		 1yix DEOXYRIBONUCLEASE
YCFH
(Escherichia
coli) 		5 / 9 THR A 163
GLY A 165
LEU A 167
LEU A 168
ILE A 174
 None
 1.17A 3nbqA-1yixA:
undetectable		 3nbqA-1yixA:
25.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9T_B_BEZB264_0
(ECHA1_1)		 1yix DEOXYRIBONUCLEASE
YCFH
(Escherichia
coli) 		4 / 7 ILE A 179
ALA A 192
ALA A 191
MET A 231
 None
 0.80A 3r9tB-1yixA:
undetectable		 3r9tB-1yixA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_A_NCTA501_1
(CYTOCHROME P450 2A13)		 1yix DEOXYRIBONUCLEASE
YCFH
(Escherichia
coli) 		4 / 7 PHE A  36
PHE A   2
PHE A 250
ALA A 251
 None
 0.91A 4ejgA-1yixA:
undetectable		 4ejgA-1yixA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H9M_A_HAEA929_1
(UREASE)		 1yix DEOXYRIBONUCLEASE
YCFH
(Escherichia
coli) 		4 / 5 HIS A   7
HIS A  67
HIS A 130
ASP A 205
 ZN  A 601 (-3.3A)
None
ZN  A 604 (-3.3A)
ZN  A 601 (-2.8A)
 0.70A 4h9mA-1yixA:
14.6		 4h9mA-1yixA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K0B_B_SAMB504_1
(S-ADENOSYLMETHIONINE
SYNTHASE)		 1yix DEOXYRIBONUCLEASE
YCFH
(Escherichia
coli) 		4 / 8 HIS A 214
PRO A 213
ASP A 226
ALA A 222
 None
 0.93A 4k0bB-1yixA:
undetectable		 4k0bB-1yixA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L7I_B_SAMB501_1
(S-ADENOSYLMETHIONINE
SYNTHASE)		 1yix DEOXYRIBONUCLEASE
YCFH
(Escherichia
coli) 		4 / 8 HIS A 214
PRO A 213
ASP A 226
ALA A 222
 None
 0.96A 4l7iB-1yixA:
undetectable		 4l7iB-1yixA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBP_C_HAEC800_1
(PROTEIN (UREASE
(CHAIN C)))		 1yix DEOXYRIBONUCLEASE
YCFH
(Escherichia
coli) 		5 / 6 HIS A   7
HIS A   9
HIS A  67
HIS A 130
ASP A 205
 ZN  A 601 (-3.3A)
ZN  A 601 (-3.2A)
None
ZN  A 604 (-3.3A)
ZN  A 601 (-2.8A)
 0.68A 4ubpC-1yixA:
15.6		 4ubpC-1yixA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZGF_A_BEZA210_0
(UNCHARACTERIZED
PROTEIN)		 1yix DEOXYRIBONUCLEASE
YCFH
(Escherichia
coli) 		4 / 4 VAL A 180
ALA A 185
ASN A 184
GLN A 187
 None
 1.40A 4zgfA-1yixA:
undetectable		 4zgfA-1yixA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_LCRA612_1
(SERUM ALBUMIN)		 1yix DEOXYRIBONUCLEASE
YCFH
(Escherichia
coli) 		5 / 9 LEU A 123
GLY A 120
LEU A  92
LEU A  80
ALA A  84
 None
 1.01A 5dqfA-1yixA:
undetectable		 5dqfA-1yixA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DCH_A_ACTA401_0
(SCOE PROTEIN)		 1yix DEOXYRIBONUCLEASE
YCFH
(Escherichia
coli) 		4 / 5 THR A  42
HIS A   7
ASP A 205
HIS A 155
 None
ZN  A 601 (-3.3A)
ZN  A 601 (-2.8A)
ZN  A 604 ( 3.2A)
 0.79A 6dchA-1yixA:
undetectable		 6dchA-1yixA:
20.77