SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1yj8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I9G_A_SAMA301_0
(HYPOTHETICAL PROTEIN
RV2118C)		 1yj8 GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
(Plasmodium
falciparum) 		5 / 12 ILE A  36
GLY A  28
GLY A  30
ALA A  35
VAL A 119
 None
 1.21A 1i9gA-1yj8A:
5.8		 1i9gA-1yj8A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_B_RITB301_2
(PROTEASE)		 1yj8 GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
(Plasmodium
falciparum) 		5 / 11 GLY A 143
ALA A 224
VAL A 329
ILE A 228
GLY A 322
 None
 0.94A 1n49B-1yj8A:
undetectable		 1n49B-1yj8A:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_D_RITD401_1
(PROTEASE)		 1yj8 GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
(Plasmodium
falciparum) 		5 / 11 GLY A 143
ALA A 224
VAL A 329
ILE A 228
GLY A 322
 None
 0.94A 1n49C-1yj8A:
undetectable		 1n49C-1yj8A:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_A_NFZA1219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 1yj8 GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
(Plasmodium
falciparum) 		4 / 8 TYR A  81
ASN A  31
GLY A  30
THR A 141
 None
 1.02A 1ykiA-1yj8A:
undetectable
1ykiB-1yj8A:
undetectable		 1ykiA-1yj8A:
19.84
1ykiB-1yj8A:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_B_NFZB2219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 1yj8 GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
(Plasmodium
falciparum) 		4 / 8 THR A 141
TYR A  81
ASN A  31
GLY A  30
 None
 1.00A 1ykiA-1yj8A:
0.0
1ykiB-1yj8A:
0.0		 1ykiA-1yj8A:
19.84
1ykiB-1yj8A:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_C_NFZC3219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 1yj8 GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
(Plasmodium
falciparum) 		4 / 8 TYR A  81
ASN A  31
GLY A  30
THR A 141
 None
 0.96A 1ykiC-1yj8A:
undetectable
1ykiD-1yj8A:
undetectable		 1ykiC-1yj8A:
19.84
1ykiD-1yj8A:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_D_NFZD4219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 1yj8 GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
(Plasmodium
falciparum) 		4 / 8 THR A 141
TYR A  81
ASN A  31
GLY A  30
 None
 0.99A 1ykiC-1yj8A:
undetectable
1ykiD-1yj8A:
undetectable		 1ykiC-1yj8A:
19.84
1ykiD-1yj8A:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVS_B_MK1B902_3
(POL POLYPROTEIN)		 1yj8 GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
(Plasmodium
falciparum) 		5 / 12 GLY A 143
ALA A 224
VAL A 329
ILE A 228
GLY A 322
 None
 1.14A 2avsB-1yj8A:
undetectable		 2avsB-1yj8A:
12.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BJF_A_DXCA330_0
(CHOLOYLGLYCINE
HYDROLASE)		 1yj8 GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
(Plasmodium
falciparum) 		5 / 12 PHE A 203
ALA A 179
ASN A  78
ILE A 108
LEU A  87
 None
 1.12A 2bjfA-1yj8A:
undetectable		 2bjfA-1yj8A:
24.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_D_MIXD3539_2
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 1yj8 GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
(Plasmodium
falciparum) 		3 / 3 VAL A 329
VAL A 324
ASP A 281
 None
 0.66A 2fumD-1yj8A:
undetectable		 2fumD-1yj8A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLC_A_CHDA332_0
(CHOLOYLGLYCINE
HYDROLASE)		 1yj8 GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
(Plasmodium
falciparum) 		5 / 12 PHE A 203
ALA A 179
ASN A  78
ILE A 108
LEU A  87
 None
 1.06A 2rlcA-1yj8A:
undetectable		 2rlcA-1yj8A:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_A_SAMA601_0
(HYPOTHETICAL PROTEIN)		 1yj8 GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
(Plasmodium
falciparum) 		5 / 12 ILE A  36
GLY A  28
GLY A  30
ALA A  35
VAL A 111
 None
 1.01A 2yvlA-1yj8A:
5.8		 2yvlA-1yj8A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_B_SAMB602_0
(HYPOTHETICAL PROTEIN)		 1yj8 GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
(Plasmodium
falciparum) 		5 / 12 ILE A  36
GLY A  28
GLY A  30
ALA A  35
VAL A 111
 None
 1.01A 2yvlB-1yj8A:
5.9		 2yvlB-1yj8A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_A_SAMA220_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 1yj8 GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
(Plasmodium
falciparum) 		5 / 12 LEU A 239
GLY A 234
GLY A 238
ALA A 232
LEU A 320
 None
 1.14A 3dh0A-1yj8A:
6.7		 3dh0A-1yj8A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 1yj8 GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
(Plasmodium
falciparum) 		5 / 12 LEU A 344
SER A 352
ILE A 351
SER A 360
LEU A 361
 None
 1.15A 3k2hB-1yj8A:
undetectable		 3k2hB-1yj8A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_B_TFPB202_2
(PROTEIN S100-A4)		 1yj8 GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
(Plasmodium
falciparum) 		4 / 6 LEU A 196
SER A 195
ILE A 188
PHE A 109
 None
 0.96A 3ko0B-1yj8A:
0.0		 3ko0B-1yj8A:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_S_TFPS202_1
(PROTEIN S100-A4)		 1yj8 GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
(Plasmodium
falciparum) 		4 / 6 LEU A 196
SER A 195
ILE A 188
PHE A 109
 None
 1.02A 3ko0S-1yj8A:
0.0		 3ko0S-1yj8A:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NV6_A_CAMA422_0
(CYTOCHROME P450)		 1yj8 GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
(Plasmodium
falciparum) 		3 / 3 GLY A  28
ILE A 101
VAL A 100
 None
 0.48A 3nv6A-1yj8A:
undetectable		 3nv6A-1yj8A:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QJ7_A_SPMA264_1
(THYMIDYLATE SYNTHASE)		 1yj8 GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
(Plasmodium
falciparum) 		4 / 8 ALA A 135
LEU A 107
ASP A 192
SER A 195
 None
 0.88A 3qj7A-1yj8A:
undetectable
3qj7D-1yj8A:
undetectable		 3qj7A-1yj8A:
19.00
3qj7D-1yj8A:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_A_FUNA201_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 1yj8 GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
(Plasmodium
falciparum) 		5 / 11 SER A  25
ILE A  24
VAL A  40
VAL A 202
ILE A  36
 None
 1.17A 3rf4A-1yj8A:
undetectable
3rf4C-1yj8A:
undetectable		 3rf4A-1yj8A:
16.14
3rf4C-1yj8A:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_B_FUNB202_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 1yj8 GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
(Plasmodium
falciparum) 		5 / 11 ILE A  36
SER A  25
ILE A  24
VAL A  40
VAL A 202
 None
 1.13A 3rf4A-1yj8A:
undetectable
3rf4B-1yj8A:
undetectable		 3rf4A-1yj8A:
16.14
3rf4B-1yj8A:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_C_FUNC203_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 1yj8 GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
(Plasmodium
falciparum) 		5 / 11 ILE A  36
SER A  25
ILE A  24
VAL A  40
VAL A 202
 None
 1.15A 3rf4B-1yj8A:
undetectable
3rf4C-1yj8A:
undetectable		 3rf4B-1yj8A:
16.14
3rf4C-1yj8A:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RZE_A_D7VA1201_1
(HISTAMINE H1
RECEPTOR, LYSOZYME
CHIMERA)		 1yj8 GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
(Plasmodium
falciparum) 		5 / 12 ASP A 281
SER A 170
THR A 187
ILE A 188
PHE A 208
 None
 1.37A 3rzeA-1yj8A:
undetectable		 3rzeA-1yj8A:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_C_SUEC1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 1yj8 GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
(Plasmodium
falciparum) 		4 / 5 PHE A 264
TYR A 330
ILE A 145
LYS A 152
 None
 1.18A 3sueC-1yj8A:
undetectable		 3sueC-1yj8A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 1yj8 GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
(Plasmodium
falciparum) 		5 / 12 ALA A  35
SER A  34
ILE A 108
SER A 139
PHE A 203
 None
 1.21A 4c49A-1yj8A:
undetectable		 4c49A-1yj8A:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJV_D_RITD500_2
(PROTEASE)		 1yj8 GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
(Plasmodium
falciparum) 		5 / 12 GLY A 143
ALA A 224
VAL A 329
ILE A 228
GLY A 322
 None
 1.06A 4njvD-1yj8A:
undetectable		 4njvD-1yj8A:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_E_ASCE1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 1yj8 GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
(Plasmodium
falciparum) 		4 / 7 HIS A 331
ILE A 333
VAL A 329
GLN A 150
 None
 1.15A 5kkzC-1yj8A:
undetectable
5kkzE-1yj8A:
undetectable		 5kkzC-1yj8A:
19.95
5kkzE-1yj8A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_K_ASCK1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 1yj8 GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
(Plasmodium
falciparum) 		4 / 7 HIS A 331
ILE A 333
VAL A 329
GLN A 150
 None
 1.13A 5kkzK-1yj8A:
undetectable
5kkzQ-1yj8A:
0.0		 5kkzK-1yj8A:
21.70
5kkzQ-1yj8A:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_O_ASCO1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 1yj8 GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
(Plasmodium
falciparum) 		4 / 7 HIS A 331
ILE A 333
VAL A 329
GLN A 150
 None
 1.18A 5kkzM-1yj8A:
undetectable
5kkzO-1yj8A:
undetectable		 5kkzM-1yj8A:
19.95
5kkzO-1yj8A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5PHH_A_LDPA414_1
(LYSINE-SPECIFIC
DEMETHYLASE 4D)		 1yj8 GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
(Plasmodium
falciparum) 		4 / 6 GLU A 117
ALA A 121
LEU A 120
TYR A 157
 None
 0.99A 5phhA-1yj8A:
undetectable		 5phhA-1yj8A:
23.15