SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1yjg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IVU_A_ZD6A3015_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		 1yjg SURFACE PROTEIN VSPA
(Borrelia
turicatae) 		3 / 3 ALA A 104
GLY A  97
SER A  67
 None
 0.50A 2ivuA-1yjgA:
3.5		 2ivuA-1yjgA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_A_NIMA701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1yjg SURFACE PROTEIN VSPA
(Borrelia
turicatae) 		3 / 3 VAL A 129
SER A 133
LEU A 109
 None
 0.62A 3n8xA-1yjgA:
undetectable		 3n8xA-1yjgA:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUK_A_AERA601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 1yjg SURFACE PROTEIN VSPA
(Borrelia
turicatae) 		5 / 12 ALA A 168
ASN A  91
ILE A  95
LEU A 147
ALA A 155
 None
 1.08A 3rukA-1yjgA:
undetectable		 3rukA-1yjgA:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3P_A_ACTA1223_0
(UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 15)		 1yjg SURFACE PROTEIN VSPA
(Borrelia
turicatae) 		4 / 5 ASP A  60
THR A  63
LEU A  64
LYS A 108
 None
 0.97A 4a3pA-1yjgA:
undetectable		 4a3pA-1yjgA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HP1_C_PPFC601_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 1yjg SURFACE PROTEIN VSPA
(Borrelia
turicatae) 		4 / 6 ASP A 154
GLY A  76
ASP A  89
LYS A 158
 None
 1.43A 5hp1C-1yjgA:
2.6		 5hp1C-1yjgA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MWY_A_YNUA1101_0
(MINERALOCORTICOID
RECEPTOR)		 1yjg SURFACE PROTEIN VSPA
(Borrelia
turicatae) 		5 / 12 LEU A 176
LEU A 179
ASN A 180
LEU A 109
LEU A  64
 None
 1.22A 5mwyA-1yjgA:
undetectable		 5mwyA-1yjgA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_A_AQ4A602_1
(CYTOCHROME P450 1A1)		 1yjg SURFACE PROTEIN VSPA
(Borrelia
turicatae) 		4 / 5 ILE A  68
SER A  67
ALA A 104
LEU A 137
 None
 0.94A 6dwnA-1yjgA:
undetectable		 6dwnA-1yjgA:
18.35