SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1yjk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IGX_A_EPAA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 1yjk PEPTIDYL-GLYCINE
ALPHA-AMIDATING
MONOOXYGENASE
(Rattus
norvegicus) 		4 / 8 VAL A 158
VAL A 189
VAL A 191
ILE A  95
 GOL  A 702 ( 4.2A)
None
None
None
 0.88A 1igxA-1yjkA:
undetectable		 1igxA-1yjkA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YVP_B_ACTB2002_0
(60-KDA SS-A/RO
RIBONUCLEOPROTEIN)		 1yjk PEPTIDYL-GLYCINE
ALPHA-AMIDATING
MONOOXYGENASE
(Rattus
norvegicus) 		4 / 6 SER A 102
ALA A 101
SER A 187
THR A 105
 None
 1.14A 1yvpB-1yjkA:
undetectable		 1yvpB-1yjkA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I91_A_ACTA601_0
(60 KDA SS-A/RO
RIBONUCLEOPROTEIN)		 1yjk PEPTIDYL-GLYCINE
ALPHA-AMIDATING
MONOOXYGENASE
(Rattus
norvegicus) 		4 / 7 SER A 102
ALA A 101
SER A 187
THR A 105
 None
 1.08A 2i91A-1yjkA:
undetectable		 2i91A-1yjkA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OA1_B_ADNB2005_1
(TRYPTOPHAN
HALOGENASE)		 1yjk PEPTIDYL-GLYCINE
ALPHA-AMIDATING
MONOOXYGENASE
(Rattus
norvegicus) 		4 / 7 GLY A 159
GLY A 160
VAL A  94
SER A 164
 None
None
None
GOL  A 702 (-2.6A)
 0.84A 2oa1B-1yjkA:
undetectable		 2oa1B-1yjkA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCM_X_SAMX5452_0
(UNCHARACTERIZED
PROTEIN TM_1570)		 1yjk PEPTIDYL-GLYCINE
ALPHA-AMIDATING
MONOOXYGENASE
(Rattus
norvegicus) 		5 / 11 ALA A 350
GLY A 264
GLY A 252
ILE A 352
ASN A 351
 None
 0.97A 3dcmX-1yjkA:
undetectable		 3dcmX-1yjkA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3003_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 1yjk PEPTIDYL-GLYCINE
ALPHA-AMIDATING
MONOOXYGENASE
(Rattus
norvegicus) 		4 / 6 ILE A  66
VAL A 191
LEU A 193
LEU A  86
 None
 0.73A 3kp6A-1yjkA:
undetectable
3kp6B-1yjkA:
undetectable		 3kp6A-1yjkA:
20.22
3kp6B-1yjkA:
20.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MIH_A_CUA357_0
(PEPTIDYL-GLYCINE
ALPHA-AMIDATING
MONOOXYGENASE)		 1yjk PEPTIDYL-GLYCINE
ALPHA-AMIDATING
MONOOXYGENASE
(Rattus
norvegicus) 		3 / 3 HIS A 107
HIS A 108
HIS A 172
 CU  A 357 (-3.0A)
CU  A 357 (-3.0A)
CU  A 357 (-3.1A)
 0.25A 3mihA-1yjkA:
45.0		 3mihA-1yjkA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MIH_A_CUA358_0
(PEPTIDYL-GLYCINE
ALPHA-AMIDATING
MONOOXYGENASE)		 1yjk PEPTIDYL-GLYCINE
ALPHA-AMIDATING
MONOOXYGENASE
(Rattus
norvegicus) 		3 / 3 HIS A 242
HIS A 244
MET A 314
 CU  A 358 (-3.2A)
CU  A 358 (-3.2A)
CU  A 358 (-2.2A)
 0.14A 3mihA-1yjkA:
45.0		 3mihA-1yjkA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_B_SAMB300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 1yjk PEPTIDYL-GLYCINE
ALPHA-AMIDATING
MONOOXYGENASE
(Rattus
norvegicus) 		5 / 12 LEU A 317
ALA A 290
GLY A 252
SER A 251
ALA A 339
 None
 1.13A 3ou6B-1yjkA:
undetectable		 3ou6B-1yjkA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_C_SAMC300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 1yjk PEPTIDYL-GLYCINE
ALPHA-AMIDATING
MONOOXYGENASE
(Rattus
norvegicus) 		5 / 12 LEU A 317
ALA A 290
GLY A 252
SER A 251
ALA A 339
 None
 1.14A 3ou6C-1yjkA:
undetectable		 3ou6C-1yjkA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_C_SAMC300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 1yjk PEPTIDYL-GLYCINE
ALPHA-AMIDATING
MONOOXYGENASE
(Rattus
norvegicus) 		5 / 12 LEU A 317
GLY A 252
SER A 251
LEU A 289
ALA A 339
 None
 1.27A 3ou6C-1yjkA:
undetectable		 3ou6C-1yjkA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_C_SAMC300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 1yjk PEPTIDYL-GLYCINE
ALPHA-AMIDATING
MONOOXYGENASE
(Rattus
norvegicus) 		5 / 12 LEU A 317
GLY A 252
SER A 251
LEU A 289
ALA A 339
 None
 1.27A 3ou7C-1yjkA:
undetectable		 3ou7C-1yjkA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_R_CLMR221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1yjk PEPTIDYL-GLYCINE
ALPHA-AMIDATING
MONOOXYGENASE
(Rattus
norvegicus) 		5 / 10 SER A 330
PHE A 156
LEU A 193
VAL A 191
PHE A  97
 GOL  A 702 (-3.4A)
GOL  A 702 (-4.9A)
None
None
GOL  A 701 ( 4.7A)
 1.45A 3u9fR-1yjkA:
undetectable		 3u9fR-1yjkA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB2_A_DM5A602_1
(SERUM ALBUMIN)		 1yjk PEPTIDYL-GLYCINE
ALPHA-AMIDATING
MONOOXYGENASE
(Rattus
norvegicus) 		4 / 7 PRO A 151
VAL A 154
ALA A 202
TYR A 139
 None
 1.14A 4lb2A-1yjkA:
undetectable		 4lb2A-1yjkA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_B_ADNB501_2
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 1yjk PEPTIDYL-GLYCINE
ALPHA-AMIDATING
MONOOXYGENASE
(Rattus
norvegicus) 		3 / 3 PRO A 151
LEU A 150
GLN A 198
 None
GOL  A 701 (-4.5A)
GOL  A 704 (-3.6A)
 0.61A 4pevB-1yjkA:
undetectable		 4pevB-1yjkA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UDC_A_DEXA1778_2
(GLUCOCORTICOID
RECEPTOR)		 1yjk PEPTIDYL-GLYCINE
ALPHA-AMIDATING
MONOOXYGENASE
(Rattus
norvegicus) 		3 / 3 MET A 207
GLN A 266
TYR A 275
 None
 0.89A 4udcA-1yjkA:
undetectable		 4udcA-1yjkA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVM_A_DM2A303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1yjk PEPTIDYL-GLYCINE
ALPHA-AMIDATING
MONOOXYGENASE
(Rattus
norvegicus) 		5 / 12 GLY A 159
GLY A 163
THR A 162
ASN A 115
PHE A 167
 None
GOL  A 702 (-3.3A)
None
None
None
 1.27A 4zvmA-1yjkA:
undetectable
4zvmB-1yjkA:
undetectable		 4zvmA-1yjkA:
21.38
4zvmB-1yjkA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA305_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 1yjk PEPTIDYL-GLYCINE
ALPHA-AMIDATING
MONOOXYGENASE
(Rattus
norvegicus) 		3 / 3 THR A 284
MET A 234
HIS A 235
 None
 0.86A 5uunA-1yjkA:
undetectable		 5uunA-1yjkA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA609_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 1yjk PEPTIDYL-GLYCINE
ALPHA-AMIDATING
MONOOXYGENASE
(Rattus
norvegicus) 		3 / 3 HIS A 244
HIS A 245
ARG A 300
 CU  A 358 (-3.2A)
None
None
 1.05A 6b58A-1yjkA:
undetectable		 6b58A-1yjkA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BM5_A_SAMA1301_0
(METHIONINE SYNTHASE)		 1yjk PEPTIDYL-GLYCINE
ALPHA-AMIDATING
MONOOXYGENASE
(Rattus
norvegicus) 		5 / 11 PRO A 355
ALA A 273
TYR A 275
PRO A 276
ALA A 238
 None
None
None
None
GOL  A 701 (-3.7A)
 1.46A 6bm5A-1yjkA:
0.0		 6bm5A-1yjkA:
23.56