SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1yk3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BRP_A_RTLA183_0
(RETINOL BINDING
PROTEIN)		 1yk3 HYPOTHETICAL PROTEIN
RV1347C/MT1389
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 129
ALA A 131
GLY A 144
LEU A  45
PHE A 167
 None
 1.19A 1brpA-1yk3A:
2.4		 1brpA-1yk3A:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1F86_B_T44B528_1
(TRANSTHYRETIN
THR119MET VARIANT)		 1yk3 HYPOTHETICAL PROTEIN
RV1347C/MT1389
(Mycobacterium
tuberculosis) 		4 / 4 LYS A 186
LEU A 188
ALA A 202
LEU A 200
 None
 1.06A 1f86B-1yk3A:
undetectable		 1f86B-1yk3A:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8D_A_BEZA1002_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 1yk3 HYPOTHETICAL PROTEIN
RV1347C/MT1389
(Mycobacterium
tuberculosis) 		5 / 10 LEU A 106
GLY A  96
ILE A 133
LEU A 148
ILE A 151
 None
 1.06A 2f8dA-1yk3A:
undetectable		 2f8dA-1yk3A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8D_B_BEZB1003_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 1yk3 HYPOTHETICAL PROTEIN
RV1347C/MT1389
(Mycobacterium
tuberculosis) 		5 / 10 LEU A 106
GLY A  96
ILE A 133
LEU A 148
ILE A 151
 None
 1.07A 2f8dB-1yk3A:
undetectable		 2f8dB-1yk3A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_B_SAMB202_0
(UPF0066 PROTEIN
AF_0241)		 1yk3 HYPOTHETICAL PROTEIN
RV1347C/MT1389
(Mycobacterium
tuberculosis) 		5 / 12 TYR A 109
GLY A 128
LEU A 129
ASP A 168
LEU A 115
 None
 1.33A 2nv4B-1yk3A:
undetectable		 2nv4B-1yk3A:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA801_1
(TRANSPORTER)		 1yk3 HYPOTHETICAL PROTEIN
RV1347C/MT1389
(Mycobacterium
tuberculosis) 		5 / 11 LEU A  94
LEU A  45
ARG A  46
LEU A  56
ASP A  52
 None
 1.18A 2q6hA-1yk3A:
undetectable		 2q6hA-1yk3A:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q72_A_IXXA801_1
(TRANSPORTER)		 1yk3 HYPOTHETICAL PROTEIN
RV1347C/MT1389
(Mycobacterium
tuberculosis) 		5 / 11 LEU A  94
LEU A  45
ARG A  46
LEU A  56
ASP A  52
 None
 1.18A 2q72A-1yk3A:
undetectable		 2q72A-1yk3A:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA801_1
(TRANSPORTER)		 1yk3 HYPOTHETICAL PROTEIN
RV1347C/MT1389
(Mycobacterium
tuberculosis) 		5 / 11 LEU A  94
LEU A  45
ARG A  46
LEU A  56
ASP A  52
 None
 1.20A 2qeiA-1yk3A:
undetectable		 2qeiA-1yk3A:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_A_ACRA5044_2
(GLUCOSYLTRANSFERASE-
SI)		 1yk3 HYPOTHETICAL PROTEIN
RV1347C/MT1389
(Mycobacterium
tuberculosis) 		3 / 3 LEU A 203
TRP A 182
TYR A 201
 None
 0.99A 3aicA-1yk3A:
undetectable		 3aicA-1yk3A:
12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_B_ACRB5044_2
(GLUCOSYLTRANSFERASE-
SI)		 1yk3 HYPOTHETICAL PROTEIN
RV1347C/MT1389
(Mycobacterium
tuberculosis) 		3 / 3 LEU A 203
TRP A 182
TYR A 201
 None
 1.00A 3aicB-1yk3A:
undetectable		 3aicB-1yk3A:
12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_E_ACRE5044_2
(GLUCOSYLTRANSFERASE-
SI)		 1yk3 HYPOTHETICAL PROTEIN
RV1347C/MT1389
(Mycobacterium
tuberculosis) 		3 / 3 LEU A 203
TRP A 182
TYR A 201
 None
 1.01A 3aicE-1yk3A:
undetectable		 3aicE-1yk3A:
12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_H_ACRH5044_2
(GLUCOSYLTRANSFERASE-
SI)		 1yk3 HYPOTHETICAL PROTEIN
RV1347C/MT1389
(Mycobacterium
tuberculosis) 		3 / 3 LEU A 203
TRP A 182
TYR A 201
 None
 1.00A 3aicH-1yk3A:
undetectable		 3aicH-1yk3A:
12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QEL_B_QELB1_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE [NMDA]
RECEPTOR SUBUNIT
EPSILON-2)		 1yk3 HYPOTHETICAL PROTEIN
RV1347C/MT1389
(Mycobacterium
tuberculosis) 		5 / 11 ARG A  33
ALA A  48
GLN A  49
ILE A  95
GLU A  87
 None
 1.24A 3qelA-1yk3A:
undetectable
3qelB-1yk3A:
undetectable		 3qelA-1yk3A:
19.85
3qelB-1yk3A:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WSJ_A_MK1A201_1
(PROTEASE)		 1yk3 HYPOTHETICAL PROTEIN
RV1347C/MT1389
(Mycobacterium
tuberculosis) 		5 / 9 ARG A 163
ALA A 111
ASP A 114
VAL A  28
LEU A  24
 None
 1.22A 3wsjA-1yk3A:
undetectable		 3wsjA-1yk3A:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WSJ_A_MK1A201_1
(PROTEASE)		 1yk3 HYPOTHETICAL PROTEIN
RV1347C/MT1389
(Mycobacterium
tuberculosis) 		5 / 9 ARG A 163
ASP A 126
ALA A 111
VAL A  28
LEU A  24
 None
 1.39A 3wsjA-1yk3A:
undetectable		 3wsjA-1yk3A:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_B_NPSB603_1
(SERUM ALBUMIN)		 1yk3 HYPOTHETICAL PROTEIN
RV1347C/MT1389
(Mycobacterium
tuberculosis) 		5 / 11 LEU A  82
ARG A  33
VAL A  47
LEU A  50
LEU A  56
 None
 1.18A 4or0B-1yk3A:
undetectable		 4or0B-1yk3A:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PE5_C_QELC939_1
(GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 1
GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2B)		 1yk3 HYPOTHETICAL PROTEIN
RV1347C/MT1389
(Mycobacterium
tuberculosis) 		5 / 10 ARG A  33
ALA A  48
GLN A  49
ILE A  95
GLU A  87
 None
 1.25A 4pe5C-1yk3A:
undetectable
4pe5D-1yk3A:
undetectable		 4pe5C-1yk3A:
13.27
4pe5D-1yk3A:
13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XJ7_A_ADNA303_1
(5'/3'-NUCLEOTIDASE
SURE)		 1yk3 HYPOTHETICAL PROTEIN
RV1347C/MT1389
(Mycobacterium
tuberculosis) 		5 / 10 GLY A  44
ALA A 131
ILE A 151
LEU A  45
LEU A  39
 None
 1.16A 4xj7A-1yk3A:
undetectable
4xj7B-1yk3A:
undetectable		 4xj7A-1yk3A:
22.66
4xj7B-1yk3A:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_CZEA613_1
(SERUM ALBUMIN)		 1yk3 HYPOTHETICAL PROTEIN
RV1347C/MT1389
(Mycobacterium
tuberculosis) 		5 / 9 ALA A 131
LEU A 147
GLY A 144
LEU A 148
LEU A 129
 None
 1.20A 5dqfA-1yk3A:
undetectable		 5dqfA-1yk3A:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWJ_B_QELB503_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2B)		 1yk3 HYPOTHETICAL PROTEIN
RV1347C/MT1389
(Mycobacterium
tuberculosis) 		5 / 11 ARG A  33
ALA A  48
GLN A  49
ILE A  95
GLU A  87
 None
 1.26A 5ewjA-1yk3A:
undetectable
5ewjB-1yk3A:
undetectable		 5ewjA-1yk3A:
19.69
5ewjB-1yk3A:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWJ_D_QELD503_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2B)		 1yk3 HYPOTHETICAL PROTEIN
RV1347C/MT1389
(Mycobacterium
tuberculosis) 		5 / 12 ARG A  33
ALA A  48
GLN A  49
ILE A  95
GLU A  87
 None
 1.27A 5ewjC-1yk3A:
undetectable
5ewjD-1yk3A:
undetectable		 5ewjC-1yk3A:
19.69
5ewjD-1yk3A:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF0_A_SAMA505_1
(CARNOSINE
N-METHYLTRANSFERASE)		 1yk3 HYPOTHETICAL PROTEIN
RV1347C/MT1389
(Mycobacterium
tuberculosis) 		4 / 5 GLN A  85
TYR A  71
GLU A  20
ASP A  23
 None
 1.46A 5yf0A-1yk3A:
undetectable		 5yf0A-1yk3A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CK2_C_IPHC101_0
(INSULIN A CHAIN
INSULIN B CHAIN)		 1yk3 HYPOTHETICAL PROTEIN
RV1347C/MT1389
(Mycobacterium
tuberculosis) 		4 / 4 ILE A 165
LEU A 148
HIS A 130
ALA A 131
 None
 1.04A 6ck2C-1yk3A:
undetectable
6ck2D-1yk3A:
undetectable		 6ck2C-1yk3A:
9.09
6ck2D-1yk3A:
11.11