SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1yk9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW5_A_SAMA401_1
(MODIFICATION
METHYLASE RSRI)		 1yk9 ADENYLATE CYCLASE
(Mycobacterium
tuberculosis) 		3 / 3 ASP A 314
HIS A 290
ASP A 321
 None
 0.87A 1nw5A-1yk9A:
undetectable		 1nw5A-1yk9A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DRJ_A_RAPA201_2
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
SERINE/THREONINE-PRO
TEIN KINASE MTOR)		 1yk9 ADENYLATE CYCLASE
(Mycobacterium
tuberculosis) 		4 / 8 LEU A 276
PHE A 283
THR A 327
PHE A 260
 None
 0.92A 4drjB-1yk9A:
undetectable		 4drjB-1yk9A:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D9K_F_ACTF802_0
(UNCHARACTERIZED
PROTEIN)		 1yk9 ADENYLATE CYCLASE
(Mycobacterium
tuberculosis) 		3 / 3 TYR A 280
ALA A 330
LEU A 343
 None
 0.73A 6d9kF-1yk9A:
undetectable		 6d9kF-1yk9A:
14.87