SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1yka'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1yka MONOTHIOL
GLUTAREDOXIN YDHD
(Escherichia
coli) 		4 / 7 LEU A  74
GLN A  73
LEU A  40
PHE A  47
 None
 1.09A 2eimC-1ykaA:
undetectable
2eimJ-1ykaA:
undetectable		 2eimC-1ykaA:
16.35
2eimJ-1ykaA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBG_C_ACTC800_0
(FAD-LINKED
SULFHYDRYL OXIDASE
ALR)		 1yka MONOTHIOL
GLUTAREDOXIN YDHD
(Escherichia
coli) 		3 / 3 ASP A 113
ARG A  46
ALA A 104
 None
 0.80A 3mbgC-1ykaA:
undetectable		 3mbgC-1ykaA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_A_X2NA590_1
(CYP51 VARIANT1)		 1yka MONOTHIOL
GLUTAREDOXIN YDHD
(Escherichia
coli) 		5 / 12 TYR A  49
LEU A  19
ILE A  52
PHE A  47
GLY A  31
 None
 1.05A 5fsaA-1ykaA:
undetectable		 5fsaA-1ykaA:
12.45