SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ykd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DVX_B_DIFB125_1
(TRANSTHYRETIN)		 1ykd ADENYLATE CYCLASE
(Anabaena
sp.) 		4 / 7 LYS A 200
ALA A 101
LEU A 180
THR A 104
 None
 0.87A 1dvxA-1ykdA:
undetectable		 1dvxA-1ykdA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DVX_B_DIFB125_2
(TRANSTHYRETIN)		 1ykd ADENYLATE CYCLASE
(Anabaena
sp.) 		4 / 7 LYS A 200
ALA A 101
LEU A 180
THR A 104
 None
 0.88A 1dvxB-1ykdA:
undetectable		 1dvxB-1ykdA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_2
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1ykd ADENYLATE CYCLASE
(Anabaena
sp.) 		3 / 3 LEU A  65
VAL A  68
LEU A  72
 None
 0.52A 1mz9B-1ykdA:
undetectable		 1mz9B-1ykdA:
8.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)		 1ykd ADENYLATE CYCLASE
(Anabaena
sp.) 		5 / 12 TYR A 344
ALA A 350
SER A 349
GLY A 360
TYR A 396
 None
 1.20A 1nbiC-1ykdA:
undetectable		 1nbiC-1ykdA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 1ykd ADENYLATE CYCLASE
(Anabaena
sp.) 		5 / 12 TYR A 344
ALA A 350
SER A 349
GLY A 360
TYR A 396
 None
 1.22A 1nbiD-1ykdA:
undetectable		 1nbiD-1ykdA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U18_B_HSMB402_1
(NITROPHORIN 1)		 1ykd ADENYLATE CYCLASE
(Anabaena
sp.) 		4 / 5 ASP A 224
THR A  95
LEU A  98
LEU A  99
 None
 1.20A 1u18B-1ykdA:
undetectable		 1u18B-1ykdA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAT_A_FK5A108_1
(FK506 BINDING
PROTEIN)		 1ykd ADENYLATE CYCLASE
(Anabaena
sp.) 		5 / 11 PHE A 228
VAL A 195
ILE A 106
LEU A 237
ILE A 238
 None
 1.29A 1yatA-1ykdA:
undetectable		 1yatA-1ykdA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CFQ_A_DIFA1_1
(TRANSTHYRETIN)		 1ykd ADENYLATE CYCLASE
(Anabaena
sp.) 		4 / 6 LYS A 200
ALA A 101
LEU A 180
THR A 104
 None
 0.86A 3cfqA-1ykdA:
undetectable		 3cfqA-1ykdA:
12.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CFQ_B_DIFB1_1
(TRANSTHYRETIN)		 1ykd ADENYLATE CYCLASE
(Anabaena
sp.) 		4 / 7 LYS A 200
ALA A 101
LEU A 180
THR A 104
 None
 0.98A 3cfqA-1ykdA:
undetectable
3cfqB-1ykdA:
undetectable		 3cfqA-1ykdA:
12.94
3cfqB-1ykdA:
12.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDU_D_ROCD100_3
(PROTEASE)		 1ykd ADENYLATE CYCLASE
(Anabaena
sp.) 		3 / 3 ARG A 236
VAL A 120
THR A  92
 None
 0.81A 3nduD-1ykdA:
undetectable		 3nduD-1ykdA:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OF4_B_ACTB313_0
(NITROREDUCTASE)		 1ykd ADENYLATE CYCLASE
(Anabaena
sp.) 		3 / 3 ALA A 121
VAL A 120
GLN A  89
 CMP  A 501 ( 4.0A)
None
None
 0.58A 3of4B-1ykdA:
undetectable		 3of4B-1ykdA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TL9_A_ROCA401_2
(PROTEASE)		 1ykd ADENYLATE CYCLASE
(Anabaena
sp.) 		3 / 3 ARG A 236
VAL A 120
THR A  92
 None
 0.86A 3tl9A-1ykdA:
undetectable		 3tl9A-1ykdA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_A_ACTA860_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1ykd ADENYLATE CYCLASE
(Anabaena
sp.) 		4 / 5 GLY A 328
ILE A 322
TRP A 295
VAL A 381
 None
 1.08A 4d33A-1ykdA:
undetectable		 4d33A-1ykdA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_A_LNLA701_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1ykd ADENYLATE CYCLASE
(Anabaena
sp.) 		4 / 5 ARG A 362
VAL A 385
LEU A 366
SER A 365
 None
 1.03A 4e1gA-1ykdA:
undetectable		 4e1gA-1ykdA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I89_A_1FLA201_1
(TRANSTHYRETIN)		 1ykd ADENYLATE CYCLASE
(Anabaena
sp.) 		4 / 6 LYS A 200
ALA A 101
LEU A 180
THR A 104
 None
 0.91A 4i89A-1ykdA:
undetectable		 4i89A-1ykdA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKJ_A_SUZA201_1
(TRANSTHYRETIN)		 1ykd ADENYLATE CYCLASE
(Anabaena
sp.) 		4 / 7 LYS A 200
ALA A 101
LEU A 180
THR A 104
 None
 1.01A 4ikjA-1ykdA:
undetectable
4ikjB-1ykdA:
undetectable		 4ikjA-1ykdA:
15.98
4ikjB-1ykdA:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKK_B_SUZB201_1
(TRANSTHYRETIN)		 1ykd ADENYLATE CYCLASE
(Anabaena
sp.) 		4 / 7 LYS A 200
ALA A 101
LEU A 180
THR A 104
 None
 1.04A 4ikkA-1ykdA:
undetectable
4ikkB-1ykdA:
undetectable		 4ikkA-1ykdA:
15.98
4ikkB-1ykdA:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKL_B_SUZB201_1
(TRANSTHYRETIN)		 1ykd ADENYLATE CYCLASE
(Anabaena
sp.) 		4 / 8 LYS A 200
ALA A 101
LEU A 180
THR A 104
 None
 0.98A 4iklA-1ykdA:
undetectable
4iklB-1ykdA:
undetectable		 4iklA-1ykdA:
15.98
4iklB-1ykdA:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_C_STRC601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 1ykd ADENYLATE CYCLASE
(Anabaena
sp.) 		4 / 5 ILE A 139
ASP A 136
GLU A 142
VAL A 194
 CMP  A 501 (-4.2A)
None
None
None
 1.16A 4nkxC-1ykdA:
undetectable		 4nkxC-1ykdA:
24.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTB_A_SAMA501_1
(HYDG PROTEIN)		 1ykd ADENYLATE CYCLASE
(Anabaena
sp.) 		3 / 3 GLU A 130
ARG A 132
GLN A  85
 None
 0.94A 4rtbA-1ykdA:
undetectable		 4rtbA-1ykdA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_J_4LEJ401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 1ykd ADENYLATE CYCLASE
(Anabaena
sp.) 		6 / 9 LEU A 272
ALA A 430
LEU A 276
ALA A 427
LEU A 294
LEU A 296
 None
 0.86A 4z91F-1ykdA:
1.6
4z91G-1ykdA:
1.9
4z91H-1ykdA:
1.5
4z91I-1ykdA:
1.6
4z91J-1ykdA:
undetectable		 4z91F-1ykdA:
20.65
4z91G-1ykdA:
20.65
4z91H-1ykdA:
20.65
4z91I-1ykdA:
20.65
4z91J-1ykdA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_J_4LEJ401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 1ykd ADENYLATE CYCLASE
(Anabaena
sp.) 		6 / 9 LEU A 272
ALA A 430
LEU A 276
ALA A 427
LEU A 294
LEU A 296
 None
 1.01A 4z91F-1ykdA:
1.6
4z91G-1ykdA:
1.9
4z91H-1ykdA:
1.5
4z91I-1ykdA:
1.6
4z91J-1ykdA:
undetectable		 4z91F-1ykdA:
20.65
4z91G-1ykdA:
20.65
4z91H-1ykdA:
20.65
4z91I-1ykdA:
20.65
4z91J-1ykdA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_J_4LEJ401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 1ykd ADENYLATE CYCLASE
(Anabaena
sp.) 		6 / 9 LEU A 276
ALA A 427
LEU A 294
LEU A 296
LEU A 272
ALA A 430
 None
 0.84A 4z91F-1ykdA:
1.6
4z91G-1ykdA:
1.9
4z91H-1ykdA:
1.5
4z91I-1ykdA:
1.6
4z91J-1ykdA:
undetectable		 4z91F-1ykdA:
20.65
4z91G-1ykdA:
20.65
4z91H-1ykdA:
20.65
4z91I-1ykdA:
20.65
4z91J-1ykdA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECF_I_DVAI3010_0
(VLM2
DODECADEPSIPEPTIDE)		 1ykd ADENYLATE CYCLASE
(Anabaena
sp.) 		3 / 3 PHE A 156
ARG A 161
ALA A 181
 None
 0.81A 6ecfB-1ykdA:
undetectable		 6ecfB-1ykdA:
21.15