SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1yke'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1NP1_A_HSMA303_1 (NITROPHORIN 1)	1yke	RNA POLYMERASE II MEDIATOR COMPLEX PROTEIN MED7 (Saccharomyces cerevisiae)	4 / 5	GLU A 180 LEU A 178 LEU A 177 LEU A 182	None	1.14A	1np1A-1ykeA: undetectable	1np1A-1ykeA: 19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2AB2_A_SNLA502_2 (MINERALOCORTICOID RECEPTOR)	1yke	RNA POLYMERASE II MEDIATOR COMPLEX PROTEIN MED7 (Saccharomyces cerevisiae)	4 / 6	LEU A 155 LEU A 122 LEU A 123 LEU A 162	None	0.96A	2ab2A-1ykeA: undetectable	2ab2A-1ykeA: 17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3H5G_C_LEIC16_0 (COIL SER L16D-PEN)	1yke	RNA POLYMERASE II MEDIATOR COMPLEX PROTEIN MED7 (Saccharomyces cerevisiae)	4 / 6	LEU A 122 GLN A 117 LEU A 119 GLU A 118	None	1.12A	3h5gB-1ykeA: undetectable 3h5gC-1ykeA: undetectable	3h5gB-1ykeA: 12.96 3h5gC-1ykeA: 12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5JS5_A_ASCA202_0 (CYTOCHROME C')	1yke	RNA POLYMERASE II MEDIATOR COMPLEX PROTEIN MED7 (Saccharomyces cerevisiae)	3 / 3	CYH A 196 LYS A 197 HIS A 200	None	1.06A	5js5A-1ykeA: 2.6	5js5A-1ykeA: 20.83

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1NP1_A_HSMA303_1","NITROPHORIN 1","1yke","RNA POLYMERASE II MEDIATOR COMPLEX PROTEIN MED7","Saccharomyces cerevisiae",4,"GLU A 180;LEU A 178;LEU A 177;LEU A 182","None","1.14A","1np1A-1ykeA:undetectable","1np1A-1ykeA:19.05"],["2AB2_A_SNLA502_2","MINERALOCORTICOID RECEPTOR","1yke","RNA POLYMERASE II MEDIATOR COMPLEX PROTEIN MED7","Saccharomyces cerevisiae",4,"LEU A 155;LEU A 122;LEU A 123;LEU A 162","None","0.96A","2ab2A-1ykeA:undetectable","2ab2A-1ykeA:17.36"],["3H5G_C_LEIC16_0","COIL SER L16D-PEN","1yke","RNA POLYMERASE II MEDIATOR COMPLEX PROTEIN MED7","Saccharomyces cerevisiae",4,"LEU A 122;GLN A 117;LEU A 119;GLU A 118","None","1.12A","3h5gB-1ykeA:undetectable;3h5gC-1ykeA:undetectable","3h5gB-1ykeA:12.96;3h5gC-1ykeA:12.96"],["5JS5_A_ASCA202_0","CYTOCHROME C'","1yke","RNA POLYMERASE II MEDIATOR COMPLEX PROTEIN MED7","Saccharomyces cerevisiae",3,"CYH A 196;LYS A 197;HIS A 200","None","1.06A","5js5A-1ykeA:2.6","5js5A-1ykeA:20.83"]]