SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1yks'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DB1_A_VDXA428_1
(VITAMIN D NUCLEAR
RECEPTOR)		 1yks GENOME POLYPROTEIN
[CONTAINS:
FLAVIVIRIN PROTEASE
NS3 CATALYTIC
SUBUNIT]
(Yellow
fever
virus) 		5 / 12 LEU A 540
LEU A 546
CYH A 567
VAL A 536
LEU A 529
 None
 1.35A 1db1A-1yksA:
0.0		 1db1A-1yksA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HZ4_A_BEZA784_0
(MALT REGULATORY
PROTEIN)		 1yks GENOME POLYPROTEIN
[CONTAINS:
FLAVIVIRIN PROTEASE
NS3 CATALYTIC
SUBUNIT]
(Yellow
fever
virus) 		4 / 6 TRP A 304
HIS A 307
LEU A 499
PRO A 524
 None
 1.22A 1hz4A-1yksA:
undetectable		 1hz4A-1yksA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQF_A_SAMA430_1
(SUN PROTEIN)		 1yks GENOME POLYPROTEIN
[CONTAINS:
FLAVIVIRIN PROTEASE
NS3 CATALYTIC
SUBUNIT]
(Yellow
fever
virus) 		3 / 3 PRO A 362
ASP A 359
ASP A 474
 None
 0.79A 1sqfA-1yksA:
2.3		 1sqfA-1yksA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJF_A_ADNA2001_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 1yks GENOME POLYPROTEIN
[CONTAINS:
FLAVIVIRIN PROTEASE
NS3 CATALYTIC
SUBUNIT]
(Yellow
fever
virus) 		4 / 7 ARG A 467
GLU A 425
ALA A 364
PRO A 362
 None
 1.01A 2ejfA-1yksA:
undetectable		 2ejfA-1yksA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HC4_A_VDXA525_1
(VITAMIN D RECEPTOR)		 1yks GENOME POLYPROTEIN
[CONTAINS:
FLAVIVIRIN PROTEASE
NS3 CATALYTIC
SUBUNIT]
(Yellow
fever
virus) 		5 / 12 PHE A 615
LEU A 546
CYH A 567
VAL A 536
LEU A 529
 None
 1.40A 2hc4A-1yksA:
0.0		 2hc4A-1yksA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FBX_A_ACTA608_0
(PUTATIVE
PHOSPHOLIPASE B-LIKE
2)		 1yks GENOME POLYPROTEIN
[CONTAINS:
FLAVIVIRIN PROTEASE
NS3 CATALYTIC
SUBUNIT]
(Yellow
fever
virus) 		3 / 3 GLU A 603
VAL A 445
CYH A 601
 None
 0.93A 3fbxA-1yksA:
undetectable		 3fbxA-1yksA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N5T_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE)		 1yks GENOME POLYPROTEIN
[CONTAINS:
FLAVIVIRIN PROTEASE
NS3 CATALYTIC
SUBUNIT]
(Yellow
fever
virus) 		4 / 7 SER A 234
VAL A 232
PHE A 240
GLU A 235
 None
 1.34A 3n5tA-1yksA:
undetectable
3n5tB-1yksA:
undetectable		 3n5tA-1yksA:
21.83
3n5tB-1yksA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N61_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE)		 1yks GENOME POLYPROTEIN
[CONTAINS:
FLAVIVIRIN PROTEASE
NS3 CATALYTIC
SUBUNIT]
(Yellow
fever
virus) 		4 / 7 PHE A 240
GLU A 235
SER A 234
VAL A 232
 None
 1.29A 3n61A-1yksA:
undetectable
3n61B-1yksA:
undetectable		 3n61A-1yksA:
20.42
3n61B-1yksA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ONN_A_ACTA270_0
(PROTEIN SSM1)		 1yks GENOME POLYPROTEIN
[CONTAINS:
FLAVIVIRIN PROTEASE
NS3 CATALYTIC
SUBUNIT]
(Yellow
fever
virus) 		4 / 5 LEU A 243
ARG A 218
LEU A 213
PRO A 210
 None
 1.35A 3onnA-1yksA:
undetectable		 3onnA-1yksA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JEC_B_478B401_3
(HIV-1 PROTEASE)		 1yks GENOME POLYPROTEIN
[CONTAINS:
FLAVIVIRIN PROTEASE
NS3 CATALYTIC
SUBUNIT]
(Yellow
fever
virus) 		3 / 3 ASP A 500
LEU A 275
VAL A 280
 None
 0.41A 4jecB-1yksA:
undetectable		 4jecB-1yksA:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB2_A_DM5A602_1
(SERUM ALBUMIN)		 1yks GENOME POLYPROTEIN
[CONTAINS:
FLAVIVIRIN PROTEASE
NS3 CATALYTIC
SUBUNIT]
(Yellow
fever
virus) 		4 / 7 PRO A 348
VAL A 375
MET A 376
ALA A 378
 None
 0.90A 4lb2A-1yksA:
1.1		 4lb2A-1yksA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_C_QDNC602_1
(CYTOCHROME P450 2D6)		 1yks GENOME POLYPROTEIN
[CONTAINS:
FLAVIVIRIN PROTEASE
NS3 CATALYTIC
SUBUNIT]
(Yellow
fever
virus) 		5 / 11 GLY A 303
LEU A 512
GLU A 516
ALA A 297
ASP A 295
 None
 1.19A 4wnuC-1yksA:
undetectable		 4wnuC-1yksA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADL_B_H4BB600_1
(ENDOTHELIAL NITRIC
OXIDE SYNTHASE)		 1yks GENOME POLYPROTEIN
[CONTAINS:
FLAVIVIRIN PROTEASE
NS3 CATALYTIC
SUBUNIT]
(Yellow
fever
virus) 		4 / 7 PHE A 240
GLU A 235
SER A 234
VAL A 232
 None
 1.30A 5adlA-1yksA:
undetectable
5adlB-1yksA:
undetectable		 5adlA-1yksA:
21.88
5adlB-1yksA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FJ3_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1yks GENOME POLYPROTEIN
[CONTAINS:
FLAVIVIRIN PROTEASE
NS3 CATALYTIC
SUBUNIT]
(Yellow
fever
virus) 		4 / 7 PHE A 240
GLU A 235
SER A 234
VAL A 232
 None
 1.28A 5fj3A-1yksA:
undetectable
5fj3B-1yksA:
undetectable		 5fj3A-1yksA:
21.88
5fj3B-1yksA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_C_SAMC501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 1yks GENOME POLYPROTEIN
[CONTAINS:
FLAVIVIRIN PROTEASE
NS3 CATALYTIC
SUBUNIT]
(Yellow
fever
virus) 		4 / 7 GLY A 419
LEU A 233
THR A 229
ALA A 227
 None
 0.73A 5o96C-1yksA:
undetectable		 5o96C-1yksA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA307_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 1yks GENOME POLYPROTEIN
[CONTAINS:
FLAVIVIRIN PROTEASE
NS3 CATALYTIC
SUBUNIT]
(Yellow
fever
virus) 		4 / 5 PRO A 450
GLU A 480
ARG A 431
THR A 432
 None
 1.49A 5uxcA-1yksA:
undetectable		 5uxcA-1yksA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VVN_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1yks GENOME POLYPROTEIN
[CONTAINS:
FLAVIVIRIN PROTEASE
NS3 CATALYTIC
SUBUNIT]
(Yellow
fever
virus) 		4 / 7 PHE A 240
GLU A 235
SER A 234
VAL A 232
 None
 1.29A 5vvnA-1yksA:
undetectable
5vvnB-1yksA:
undetectable		 5vvnA-1yksA:
21.88
5vvnB-1yksA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1yks GENOME POLYPROTEIN
[CONTAINS:
FLAVIVIRIN PROTEASE
NS3 CATALYTIC
SUBUNIT]
(Yellow
fever
virus) 		4 / 5 ARG A 538
MET A 274
THR A 271
LEU A 270
 None
 1.28A 5x19J-1yksA:
undetectable		 5x19J-1yksA:
8.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1yks GENOME POLYPROTEIN
[CONTAINS:
FLAVIVIRIN PROTEASE
NS3 CATALYTIC
SUBUNIT]
(Yellow
fever
virus) 		4 / 5 ARG A 538
MET A 274
THR A 271
LEU A 270
 None
 1.23A 5x1bJ-1yksA:
undetectable		 5x1bJ-1yksA:
8.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_D8ZA831_0
(GEPHYRIN)		 1yks GENOME POLYPROTEIN
[CONTAINS:
FLAVIVIRIN PROTEASE
NS3 CATALYTIC
SUBUNIT]
(Yellow
fever
virus) 		5 / 11 MET A 527
ASP A 500
LEU A 493
PRO A 296
ILE A 299
 None
 1.45A 6fgdA-1yksA:
0.7		 6fgdA-1yksA:
11.14