SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1yle'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_D_DVAD8_0
(GRAMICIDIN A)		 1yle ARGININE
N-SUCCINYLTRANSFERAS
E, ALPHA CHAIN
(Pseudomonas
aeruginosa) 		3 / 3 VAL A 276
VAL A 278
TRP A 309
 None
 0.95A 1av2C-1yleA:
undetectable
1av2D-1yleA:
undetectable		 1av2C-1yleA:
4.18
1av2D-1yleA:
4.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_D_DVAD8_0
(GRAMICIDIN D)		 1yle ARGININE
N-SUCCINYLTRANSFERAS
E, ALPHA CHAIN
(Pseudomonas
aeruginosa) 		3 / 3 VAL A 276
VAL A 278
TRP A 309
 None
 0.92A 1w5uC-1yleA:
undetectable
1w5uD-1yleA:
undetectable		 1w5uC-1yleA:
4.18
1w5uD-1yleA:
4.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WU8_C_ADNC502_1
(HYPOTHETICAL PROTEIN
PH0463)		 1yle ARGININE
N-SUCCINYLTRANSFERAS
E, ALPHA CHAIN
(Pseudomonas
aeruginosa) 		4 / 7 PHE A 254
TYR A 189
ASN A 188
VAL A  24
 None
 1.34A 1wu8A-1yleA:
undetectable
1wu8C-1yleA:
undetectable		 1wu8A-1yleA:
23.38
1wu8C-1yleA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_G_BEZG3385_0
(CES1 PROTEIN)		 1yle ARGININE
N-SUCCINYLTRANSFERAS
E, ALPHA CHAIN
(Pseudomonas
aeruginosa) 		3 / 3 SER A 142
VAL A 162
LEU A 123
 FMT  A 601 ( 4.1A)
None
FMT  A 601 (-4.4A)
 0.72A 1yajG-1yleA:
undetectable		 1yajG-1yleA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_A_SAMA2001_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 1yle ARGININE
N-SUCCINYLTRANSFERAS
E, ALPHA CHAIN
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 132
ASP A  21
ALA A  76
PHE A  61
CYH A  74
 None
 1.36A 2g70A-1yleA:
undetectable		 2g70A-1yleA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_B_SAMB2002_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 1yle ARGININE
N-SUCCINYLTRANSFERAS
E, ALPHA CHAIN
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 132
ASP A  21
ALA A  76
PHE A  61
CYH A  74
 None
 1.35A 2g70B-1yleA:
undetectable		 2g70B-1yleA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_A_SAMA2001_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 1yle ARGININE
N-SUCCINYLTRANSFERAS
E, ALPHA CHAIN
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 132
ASP A  21
ALA A  76
PHE A  61
CYH A  74
 None
 1.38A 2g72A-1yleA:
undetectable		 2g72A-1yleA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_A_DVAA8_0
(GRAMICIDIN D)		 1yle ARGININE
N-SUCCINYLTRANSFERAS
E, ALPHA CHAIN
(Pseudomonas
aeruginosa) 		3 / 3 VAL A 278
TRP A 309
VAL A 276
 None
 0.90A 2izqA-1yleA:
undetectable
2izqB-1yleA:
undetectable		 2izqA-1yleA:
4.18
2izqB-1yleA:
4.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J7X_A_ESTA1454_1
(ESTROGEN RECEPTOR
BETA)		 1yle ARGININE
N-SUCCINYLTRANSFERAS
E, ALPHA CHAIN
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 132
MET A   4
LEU A  63
GLY A 144
LEU A 291
 None
 1.28A 2j7xA-1yleA:
undetectable		 2j7xA-1yleA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_A_ACTA142_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 1yle ARGININE
N-SUCCINYLTRANSFERAS
E, ALPHA CHAIN
(Pseudomonas
aeruginosa) 		4 / 5 GLU A 163
PRO A 258
ILE A 251
GLY A 256
 CA  A 701 (-3.3A)
None
None
None
 1.09A 2qeuA-1yleA:
undetectable
2qeuC-1yleA:
undetectable		 2qeuA-1yleA:
20.47
2qeuC-1yleA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DVAC10_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 1yle ARGININE
N-SUCCINYLTRANSFERAS
E, ALPHA CHAIN
(Pseudomonas
aeruginosa) 		3 / 3 GLY A 166
GLY A 227
GLY A 257
 None
 0.42A 3bogC-1yleA:
undetectable		 3bogC-1yleA:
12.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_D_DVAD10_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 1yle ARGININE
N-SUCCINYLTRANSFERAS
E, ALPHA CHAIN
(Pseudomonas
aeruginosa) 		3 / 3 GLY A 166
GLY A 227
GLY A 257
 None
 0.39A 3bogD-1yleA:
undetectable		 3bogD-1yleA:
12.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_D_DVAD8_0
(GRAMICIDIN D)		 1yle ARGININE
N-SUCCINYLTRANSFERAS
E, ALPHA CHAIN
(Pseudomonas
aeruginosa) 		3 / 3 VAL A 276
VAL A 278
TRP A 309
 None
 0.91A 3l8lC-1yleA:
undetectable
3l8lD-1yleA:
undetectable		 3l8lC-1yleA:
4.18
3l8lD-1yleA:
4.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_A_715A801_1
(DIPEPTIDYL PEPTIDASE
4)		 1yle ARGININE
N-SUCCINYLTRANSFERAS
E, ALPHA CHAIN
(Pseudomonas
aeruginosa) 		5 / 12 ARG A 242
GLU A 139
GLY A 339
ARG A 288
VAL A 133
 None
 1.45A 4ffwA-1yleA:
undetectable		 4ffwA-1yleA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB2_A_DM5A601_1
(SERUM ALBUMIN)		 1yle ARGININE
N-SUCCINYLTRANSFERAS
E, ALPHA CHAIN
(Pseudomonas
aeruginosa) 		4 / 7 LEU A  71
VAL A  15
PRO A  13
GLU A  64
 None
 0.96A 4lb2A-1yleA:
0.0		 4lb2A-1yleA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R82_A_ACTA205_0
(OXIDOREDUCTASE)		 1yle ARGININE
N-SUCCINYLTRANSFERAS
E, ALPHA CHAIN
(Pseudomonas
aeruginosa) 		4 / 5 SER A 196
GLY A 197
GLU A 193
PHE A 254
 None
 1.29A 4r82A-1yleA:
undetectable
4r82B-1yleA:
undetectable		 4r82A-1yleA:
22.03
4r82B-1yleA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBS_A_DIFA503_1
(PENTALENIC ACID
SYNTHASE)		 1yle ARGININE
N-SUCCINYLTRANSFERAS
E, ALPHA CHAIN
(Pseudomonas
aeruginosa) 		4 / 7 THR A 236
LEU A 146
LEU A 147
ILE A 239
 FMT  A 601 (-4.3A)
None
None
None
 0.77A 4ubsA-1yleA:
undetectable		 4ubsA-1yleA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_D_SORD1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 1yle ARGININE
N-SUCCINYLTRANSFERAS
E, ALPHA CHAIN
(Pseudomonas
aeruginosa) 		4 / 6 GLU A 163
GLY A 257
GLY A 256
ASP A 255
 CA  A 701 (-3.3A)
None
None
CA  A 701 ( 4.3A)
 0.89A 5a06D-1yleA:
undetectable		 5a06D-1yleA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FUK_A_SNPA1236_1
(MROUPO)		 1yle ARGININE
N-SUCCINYLTRANSFERAS
E, ALPHA CHAIN
(Pseudomonas
aeruginosa) 		4 / 7 ILE A 267
ILE A 239
PHE A 245
LEU A 291
 None
 0.81A 5fukA-1yleA:
0.3
5fukB-1yleA:
0.1		 5fukA-1yleA:
22.95
5fukB-1yleA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA303_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 1yle ARGININE
N-SUCCINYLTRANSFERAS
E, ALPHA CHAIN
(Pseudomonas
aeruginosa) 		3 / 3 GLU A  56
TYR A  53
ARG A 155
 None
 0.85A 5uunA-1yleA:
undetectable		 5uunA-1yleA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB305_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 1yle ARGININE
N-SUCCINYLTRANSFERAS
E, ALPHA CHAIN
(Pseudomonas
aeruginosa) 		3 / 3 GLU A  56
TYR A  53
ARG A 155
 None
 0.78A 5uunB-1yleA:
undetectable		 5uunB-1yleA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 1yle ARGININE
N-SUCCINYLTRANSFERAS
E, ALPHA CHAIN
(Pseudomonas
aeruginosa) 		4 / 6 LEU A 335
VAL A 333
LEU A 325
VAL A 278
 None
 0.95A 5x7zA-1yleA:
undetectable		 5x7zA-1yleA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_A_ZOTA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 1yle ARGININE
N-SUCCINYLTRANSFERAS
E, ALPHA CHAIN
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 132
VAL A  72
GLY A  73
PHE A 300
VAL A 304
 None
 1.41A 6a94A-1yleA:
undetectable		 6a94A-1yleA:
21.71