SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1yln'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRF_A_FOLA187_0
(DIHYDROFOLATE
REDUCTASE)		 1yln HYPOTHETICAL PROTEIN
VCA0042
(Vibrio
cholerae) 		5 / 12 ILE A  61
ALA A 122
ILE A 126
PRO A 127
LEU A  33
 OSE  A  39 ( 4.5A)
None
None
None
None
 1.10A 1drfA-1ylnA:
undetectable		 1drfA-1ylnA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FXH_B_PACB1001_0
(PENICILLIN ACYLASE)		 1yln HYPOTHETICAL PROTEIN
VCA0042
(Vibrio
cholerae) 		4 / 7 SER A  40
SER A  97
ALA A  95
ILE A 105
 OSE  A  39 ( 4.2A)
None
None
None
 1.03A 1fxhA-1ylnA:
undetectable
1fxhB-1ylnA:
undetectable		 1fxhA-1ylnA:
23.66
1fxhB-1ylnA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J1G_F_SC2F1290_1
(FICOLIN-2)		 1yln HYPOTHETICAL PROTEIN
VCA0042
(Vibrio
cholerae) 		5 / 10 LEU A 145
SER A 191
LEU A 246
ASP A 192
THR A 196
 None
 1.26A 2j1gE-1ylnA:
undetectable
2j1gF-1ylnA:
0.0		 2j1gE-1ylnA:
22.76
2j1gF-1ylnA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NPN_A_SAMA4633_0
(PUTATIVE COBALAMIN
SYNTHESIS RELATED
PROTEIN)		 1yln HYPOTHETICAL PROTEIN
VCA0042
(Vibrio
cholerae) 		5 / 9 GLY A 204
THR A 203
ALA A 186
LEU A 160
LEU A 150
 None
 1.29A 2npnA-1ylnA:
undetectable		 2npnA-1ylnA:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYN_A_1UNA1001_3
(PROTEASE RETROPEPSIN)		 1yln HYPOTHETICAL PROTEIN
VCA0042
(Vibrio
cholerae) 		3 / 3 ASP A  79
THR A  48
PRO A  49
 None
 0.66A 2pynB-1ylnA:
undetectable		 2pynB-1ylnA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q64_B_1UNB1001_4
(PROTEASE RETROPEPSIN)		 1yln HYPOTHETICAL PROTEIN
VCA0042
(Vibrio
cholerae) 		3 / 3 ASP A  79
THR A  48
PRO A  49
 None
 0.66A 2q64B-1ylnA:
undetectable		 2q64B-1ylnA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QAK_A_1UNA1001_4
(PROTEASE RETROPEPSIN)		 1yln HYPOTHETICAL PROTEIN
VCA0042
(Vibrio
cholerae) 		3 / 3 ASP A  79
THR A  48
PRO A  49
 None
 0.66A 2qakB-1ylnA:
undetectable		 2qakB-1ylnA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKG_C_ROCC901_3
(PROTEASE)		 1yln HYPOTHETICAL PROTEIN
VCA0042
(Vibrio
cholerae) 		3 / 3 ASP A  79
THR A  48
PRO A  49
 None
 0.60A 3tkgD-1ylnA:
undetectable		 3tkgD-1ylnA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VHU_A_SNLA1001_2
(MINERALOCORTICOID
RECEPTOR)		 1yln HYPOTHETICAL PROTEIN
VCA0042
(Vibrio
cholerae) 		4 / 5 LEU A  44
LEU A  42
SER A 125
MET A 112
 None
 0.93A 3vhuA-1ylnA:
undetectable		 3vhuA-1ylnA:
25.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_C_ADNC301_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 1yln HYPOTHETICAL PROTEIN
VCA0042
(Vibrio
cholerae) 		5 / 9 LEU A 160
LEU A 233
LEU A 246
ASN A 247
ILE A 189
 None
 1.17A 3wdmC-1ylnA:
undetectable		 3wdmC-1ylnA:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTH_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 1yln HYPOTHETICAL PROTEIN
VCA0042
(Vibrio
cholerae) 		3 / 3 ASP A 162
LEU A 163
PHE A 141
 None
 0.74A 4pthA-1ylnA:
undetectable		 4pthA-1ylnA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTP_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 1yln HYPOTHETICAL PROTEIN
VCA0042
(Vibrio
cholerae) 		5 / 12 SER A 109
ILE A  27
ASN A  28
SER A  25
GLN A 134
 None
 1.19A 4rtpA-1ylnA:
undetectable		 4rtpA-1ylnA:
24.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_B_SORB1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 1yln HYPOTHETICAL PROTEIN
VCA0042
(Vibrio
cholerae) 		4 / 7 ARG A 211
ASP A 183
ILE A 206
TYR A 218
 None
 1.38A 5a06B-1ylnA:
undetectable		 5a06B-1ylnA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CU6_A_ACTA403_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 1yln HYPOTHETICAL PROTEIN
VCA0042
(Vibrio
cholerae) 		4 / 6 ILE A 114
VAL A  71
PRO A  74
ALA A 122
 None
 0.91A 5cu6A-1ylnA:
undetectable		 5cu6A-1ylnA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5F_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA
TYPE-8,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 1yln HYPOTHETICAL PROTEIN
VCA0042
(Vibrio
cholerae) 		4 / 8 THR A  58
SER A 109
MET A  73
ALA A 122
 None
 1.01A 5l5fY-1ylnA:
undetectable
5l5fZ-1ylnA:
undetectable		 5l5fY-1ylnA:
23.19
5l5fZ-1ylnA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 1yln HYPOTHETICAL PROTEIN
VCA0042
(Vibrio
cholerae) 		4 / 6 LYS A 205
LEU A 220
PHE A 170
LEU A 187
 None
 1.16A 5x19P-1ylnA:
undetectable		 5x19P-1ylnA:
24.32