SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ylo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMY_A_AZMA400_1
(MURINE CARBONIC
ANHYDRASE V)		 1ylo HYPOTHETICAL PROTEIN
SF2450
(Shigella
flexneri) 		5 / 11 VAL A 265
LEU A 329
LEU A 333
THR A 334
THR A 337
 None
 1.32A 1dmyA-1yloA:
undetectable		 1dmyA-1yloA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_B_CCSB381_0
(ESTROGEN RECEPTOR)		 1ylo HYPOTHETICAL PROTEIN
SF2450
(Shigella
flexneri) 		3 / 3 GLU A  65
ALA A  16
SER A 196
 None
 0.69A 1errB-1yloA:
undetectable		 1errB-1yloA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GXS_A_BEZA601_0
(P-(S)-HYDROXYMANDELO
NITRILE LYASE CHAIN
A
P-(S)-HYDROXYMANDELO
NITRILE LYASE CHAIN
B)		 1ylo HYPOTHETICAL PROTEIN
SF2450
(Shigella
flexneri) 		4 / 7 GLY A 204
ASP A 221
SER A 195
HIS A  62
 None
ZN  A1446 (-2.2A)
None
ZN  A1446 (-3.3A)
 1.00A 1gxsA-1yloA:
3.3
1gxsB-1yloA:
undetectable		 1gxsA-1yloA:
21.27
1gxsB-1yloA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GXS_A_BEZA601_0
(P-(S)-HYDROXYMANDELO
NITRILE LYASE CHAIN
A
P-(S)-HYDROXYMANDELO
NITRILE LYASE CHAIN
B)		 1ylo HYPOTHETICAL PROTEIN
SF2450
(Shigella
flexneri) 		4 / 7 GLY A 205
ASP A 221
SER A 195
HIS A  62
 None
ZN  A1446 (-2.2A)
None
ZN  A1446 (-3.3A)
 0.71A 1gxsA-1yloA:
3.3
1gxsB-1yloA:
undetectable		 1gxsA-1yloA:
21.27
1gxsB-1yloA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PJ7_A_FFOA2887_1
(N,N-DIMETHYLGLYCINE
OXIDASE)		 1ylo HYPOTHETICAL PROTEIN
SF2450
(Shigella
flexneri) 		3 / 3 ASP A 149
THR A 147
GLU A  21
 None
 0.78A 1pj7A-1yloA:
2.2		 1pj7A-1yloA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_B_FUAB703_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1ylo HYPOTHETICAL PROTEIN
SF2450
(Shigella
flexneri) 		3 / 3 VAL A  45
ALA A 194
HIS A  62
 None
None
ZN  A1446 (-3.3A)
 0.76A 1q23C-1yloA:
undetectable		 1q23C-1yloA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QHS_A_CLMA999_0
(PROTEIN
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE))		 1ylo HYPOTHETICAL PROTEIN
SF2450
(Shigella
flexneri) 		5 / 12 VAL A 125
ILE A  79
ILE A 140
ILE A 107
VAL A  97
 None
 1.00A 1qhsA-1yloA:
2.1		 1qhsA-1yloA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QHY_A_CLMA999_0
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE)		 1ylo HYPOTHETICAL PROTEIN
SF2450
(Shigella
flexneri) 		5 / 12 VAL A 125
ILE A  79
ILE A 140
ILE A 107
VAL A  97
 None
 1.04A 1qhyA-1yloA:
2.4		 1qhyA-1yloA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T69_A_SHHA379_1
(HISTONE DEACETYLASE
8)		 1ylo HYPOTHETICAL PROTEIN
SF2450
(Shigella
flexneri) 		5 / 12 ASP A 249
HIS A 308
GLY A 281
PHE A 278
ASP A 166
 None
ZN  A1447 (-3.2A)
None
None
ZN  A1446 ( 2.3A)
 1.43A 1t69A-1yloA:
undetectable		 1t69A-1yloA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVD_B_SAMB601_1
(CATECHOL-O-METHYLTRA
NSFERASE)		 1ylo HYPOTHETICAL PROTEIN
SF2450
(Shigella
flexneri) 		3 / 3 SER A 170
GLU A 198
ASP A 249
 None
ZN  A1446 ( 4.6A)
None
 0.73A 2avdB-1yloA:
undetectable		 2avdB-1yloA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_D_MIXD3539_2
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 1ylo HYPOTHETICAL PROTEIN
SF2450
(Shigella
flexneri) 		3 / 3 VAL A 212
VAL A  57
ASP A 167
 None
None
ZN  A1446 ( 4.5A)
 0.72A 2fumD-1yloA:
undetectable		 2fumD-1yloA:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_C_ACTC141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 1ylo HYPOTHETICAL PROTEIN
SF2450
(Shigella
flexneri) 		3 / 3 VAL A 339
ASP A 343
GLU A 336
 None
 0.74A 2qeuC-1yloA:
undetectable		 2qeuC-1yloA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G88_A_SAMA303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 1ylo HYPOTHETICAL PROTEIN
SF2450
(Shigella
flexneri) 		6 / 11 GLY A  43
GLY A  41
ASP A  40
ALA A 208
THR A 207
ALA A 194
 None
 1.13A 3g88A-1yloA:
undetectable		 3g88A-1yloA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G88_B_SAMB303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 1ylo HYPOTHETICAL PROTEIN
SF2450
(Shigella
flexneri) 		6 / 11 GLY A  43
GLY A  41
ASP A  40
ALA A 208
THR A 207
ALA A 194
 None
 1.12A 3g88B-1yloA:
undetectable		 3g88B-1yloA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G89_A_SAMA303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 1ylo HYPOTHETICAL PROTEIN
SF2450
(Shigella
flexneri) 		5 / 12 GLY A  43
GLY A  41
ASP A  40
ALA A 208
ALA A 194
 None
 0.95A 3g89A-1yloA:
undetectable		 3g89A-1yloA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G89_B_SAMB303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 1ylo HYPOTHETICAL PROTEIN
SF2450
(Shigella
flexneri) 		6 / 11 GLY A  43
GLY A  41
ASP A  40
ALA A 208
THR A 207
ALA A 194
 None
 1.14A 3g89B-1yloA:
undetectable		 3g89B-1yloA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8B_A_SAMA303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 1ylo HYPOTHETICAL PROTEIN
SF2450
(Shigella
flexneri) 		6 / 12 GLY A  43
GLY A  41
ASP A  40
ALA A 208
THR A 207
ALA A 194
 None
 1.17A 3g8bA-1yloA:
undetectable		 3g8bA-1yloA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8B_B_SAMB303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 1ylo HYPOTHETICAL PROTEIN
SF2450
(Shigella
flexneri) 		6 / 12 GLY A  43
GLY A  41
ASP A  40
ALA A 208
THR A 207
ALA A 194
 None
 1.13A 3g8bB-1yloA:
undetectable		 3g8bB-1yloA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3O_A_DLUA399_1
(PFV INTEGRASE)		 1ylo HYPOTHETICAL PROTEIN
SF2450
(Shigella
flexneri) 		4 / 7 ASP A 221
ASP A 166
GLU A 198
ARG A  88
 ZN  A1446 (-2.2A)
ZN  A1446 ( 2.3A)
ZN  A1446 ( 4.6A)
None
 1.23A 3s3oA-1yloA:
undetectable		 3s3oA-1yloA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA504_1
(CYTOCHROME P450 2B4)		 1ylo HYPOTHETICAL PROTEIN
SF2450
(Shigella
flexneri) 		5 / 9 LEU A  26
LEU A   9
GLN A  24
GLU A  21
GLU A  65
 None
 1.05A 3tmzA-1yloA:
undetectable		 3tmzA-1yloA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OT2_A_ACTA605_0
(SERUM ALBUMIN)		 1ylo HYPOTHETICAL PROTEIN
SF2450
(Shigella
flexneri) 		3 / 3 LYS A 106
LYS A 163
ALA A  12
 None
 1.41A 4ot2A-1yloA:
0.0		 4ot2A-1yloA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_A_ADNA501_2
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 1ylo HYPOTHETICAL PROTEIN
SF2450
(Shigella
flexneri) 		3 / 3 PRO A 156
LEU A 155
HIS A 306
 None
 0.65A 4pevA-1yloA:
3.6		 4pevA-1yloA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PQA_A_X8ZA401_1
(SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE)		 1ylo HYPOTHETICAL PROTEIN
SF2450
(Shigella
flexneri) 		6 / 11 HIS A  62
ASP A 166
GLU A 198
GLU A 199
GLY A 281
HIS A 308
 ZN  A1446 (-3.3A)
ZN  A1446 ( 2.3A)
ZN  A1446 ( 4.6A)
ZN  A1447 (-2.0A)
None
ZN  A1447 (-3.2A)
 0.75A 4pqaA-1yloA:
23.5		 4pqaA-1yloA:
25.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XEY_A_1N1A601_2
(TYROSINE-PROTEIN
KINASE ABL1)		 1ylo HYPOTHETICAL PROTEIN
SF2450
(Shigella
flexneri) 		3 / 3 MET A  58
ASP A  40
PHE A  39
 None
 1.06A 4xeyA-1yloA:
undetectable		 4xeyA-1yloA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJ8_A_SUVA2001_1
(HUMAN OX1R FUSION
PROTEIN TO P.ABYSII
GLYCOGEN SYNTHASE)		 1ylo HYPOTHETICAL PROTEIN
SF2450
(Shigella
flexneri) 		5 / 12 ALA A  30
VAL A  37
GLN A  24
MET A  63
GLU A  19
 None
 1.47A 4zj8A-1yloA:
3.4		 4zj8A-1yloA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECK_D_ILED601_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 1ylo HYPOTHETICAL PROTEIN
SF2450
(Shigella
flexneri) 		4 / 6 ALA A 208
THR A 209
VAL A 212
VAL A 219
 None
 0.92A 5eckD-1yloA:
undetectable		 5eckD-1yloA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECM_D_LEUD602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 1ylo HYPOTHETICAL PROTEIN
SF2450
(Shigella
flexneri) 		4 / 7 ALA A 208
THR A 209
VAL A 212
VAL A 219
 None
 0.76A 5ecmD-1yloA:
undetectable		 5ecmD-1yloA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HV1_A_RFPA902_1
(PHOSPHOENOLPYRUVATE
SYNTHASE)		 1ylo HYPOTHETICAL PROTEIN
SF2450
(Shigella
flexneri) 		5 / 12 PRO A 187
ALA A 188
VAL A  57
LEU A 258
ILE A 269
 None
 1.22A 5hv1A-1yloA:
undetectable		 5hv1A-1yloA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V3C_A_AMHA402_1
(QUEUINE
TRNA-RIBOSYLTRANSFER
ASE)		 1ylo HYPOTHETICAL PROTEIN
SF2450
(Shigella
flexneri) 		5 / 9 ASP A  40
GLY A 204
GLY A 205
ALA A 287
VAL A 288
 None
 1.16A 5v3cA-1yloA:
0.0		 5v3cA-1yloA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZW2_A_ACTA511_0
(L-PROLYL-[PEPTIDYL-C
ARRIER PROTEIN]
DEHYDROGENASE)		 1ylo HYPOTHETICAL PROTEIN
SF2450
(Shigella
flexneri) 		3 / 3 ARG A 145
ILE A  15
SER A  18
 None
 0.76A 5zw2A-1yloA:
undetectable		 5zw2A-1yloA:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B4Y_A_OAQA302_0
(SULFOTRANSFERASE
OXAMNIQUINE
RESISTANCE PROTEIN)		 1ylo HYPOTHETICAL PROTEIN
SF2450
(Shigella
flexneri) 		5 / 10 ASP A 167
VAL A 299
ASP A 276
PHE A 278
THR A 283
 ZN  A1446 ( 4.5A)
None
None
None
None
 1.43A 6b4yA-1yloA:
1.2		 6b4yA-1yloA:
21.39