SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ym0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AQ7_B_AG2B4_1
(TRYPSIN
AERUGINOSIN 98-B)		 1ym0 FIBRINOTIC ENZYME
COMPONENT B
(Eisenia
fetida) 		7 / 8 HIS A  57
ASP A 189
SER A 190
SER A 195
VAL A 213
GLY A 216
GLY A 226
 None
 0.45A 1aq7A-1ym0A:
35.9		 1aq7A-1ym0A:
39.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1BCU_H_PRLH280_0
(ALPHA-THROMBIN)		 1ym0 FIBRINOTIC ENZYME
COMPONENT B
(Eisenia
fetida) 		6 / 9 ASP A 189
SER A 195
VAL A 213
TRP A 215
GLY A 216
GLY A 226
 None
 0.38A 1bcuH-1ym0A:
36.3		 1bcuH-1ym0A:
33.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DWC_H_MITH1_1
(ALPHA-THROMBIN
(LARGE SUBUNIT))		 1ym0 FIBRINOTIC ENZYME
COMPONENT B
(Eisenia
fetida) 		5 / 9 HIS A  57
ASP A 189
SER A 195
TRP A 215
GLY A 226
 None
 0.36A 1dwcH-1ym0A:
35.4		 1dwcH-1ym0A:
33.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ETR_H_MITH1_1
(EPSILON-THROMBIN)		 1ym0 FIBRINOTIC ENZYME
COMPONENT B
(Eisenia
fetida) 		8 / 12 HIS A  57
LEU A  99
ASP A 189
SER A 195
VAL A 213
TRP A 215
GLY A 216
GLY A 226
 None
 0.57A 1etrH-1ym0A:
35.7		 1etrH-1ym0A:
33.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1F5L_A_AMRA301_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 1ym0 FIBRINOTIC ENZYME
COMPONENT B
(Eisenia
fetida) 		7 / 8 ASP A 189
SER A 190
GLN A 192
SER A 195
VAL A 213
GLY A 216
GLY A 226
 None
 0.52A 1f5lA-1ym0A:
35.1		 1f5lA-1ym0A:
33.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG1_A_SPMA999_1
(TYROSYL-DNA
PHOSPHODIESTERASE 1)		 1ym0 FIBRINOTIC ENZYME
COMPONENT B
(Eisenia
fetida) 		3 / 3 TRP B   1
VAL B   1
PRO B   1
 None
None
PCA  B   1 ( 4.5A)
 0.88A 1rg1A-1ym0B:
undetectable		 1rg1A-1ym0B:
5.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RH0_A_SPMA999_1
(TYROSYL-DNA
PHOSPHODIESTERASE 1)		 1ym0 FIBRINOTIC ENZYME
COMPONENT B
(Eisenia
fetida) 		3 / 3 TRP B   1
VAL B   1
PRO B   1
 None
None
PCA  B   1 ( 4.5A)
 0.88A 1rh0A-1ym0B:
undetectable		 1rh0A-1ym0B:
5.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TNL_A_TPAA900_1
(TRYPSIN)		 1ym0 FIBRINOTIC ENZYME
COMPONENT B
(Eisenia
fetida) 		6 / 6 ASP A 189
SER A 190
SER A 195
VAL A 213
GLY A 216
GLY A 226
 None
 0.27A 1tnlA-1ym0A:
36.1		 1tnlA-1ym0A:
39.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_4
(POL POLYPROTEIN)		 1ym0 FIBRINOTIC ENZYME
COMPONENT B
(Eisenia
fetida) 		3 / 3 ARG A 134
VAL A 231
GLY A 197
 SO4  A 502 ( 3.6A)
None
None
 0.49A 2avvE-1ym0A:
undetectable		 2avvE-1ym0A:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IVU_A_ZD6A3015_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		 1ym0 FIBRINOTIC ENZYME
COMPONENT B
FIBRINOTIC ENZYME
COMPONENT B
(Eisenia
fetida;
Eisenia
fetida) 		3 / 3 ALA B   9
GLY B   2
SER A 200
 None
 0.54A 2ivuA-1ym0B:
undetectable		 2ivuA-1ym0B:
6.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OTV_A_NCAA1301_0
(CATIONIC TRYPSIN)		 1ym0 FIBRINOTIC ENZYME
COMPONENT B
(Eisenia
fetida) 		6 / 6 ASP A 189
SER A 190
SER A 195
VAL A 213
GLY A 216
GLY A 226
 None
 0.24A 2otvA-1ym0A:
36.2		 2otvA-1ym0A:
39.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2P16_A_GG2A298_1
(COAGULATION FACTOR X
(EC 3.4.21.6)
(STUART FACTOR)
(STUART-PROWER
FACTOR))		 1ym0 FIBRINOTIC ENZYME
COMPONENT B
(Eisenia
fetida) 		7 / 12 ASP A 189
SER A 195
VAL A 213
TRP A 215
GLY A 216
GLY A 226
TYR A 228
 None
 0.30A 2p16A-1ym0A:
36.6		 2p16A-1ym0A:
32.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2VIN_A_505A1247_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR CHAIN B)		 1ym0 FIBRINOTIC ENZYME
COMPONENT B
(Eisenia
fetida) 		6 / 8 ASP A 189
SER A 190
GLN A 192
SER A 195
VAL A 213
GLY A 226
 None
 0.67A 2vinA-1ym0A:
36.0		 2vinA-1ym0A:
33.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2VIN_A_505A1247_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR CHAIN B)		 1ym0 FIBRINOTIC ENZYME
COMPONENT B
(Eisenia
fetida) 		6 / 8 ASP A 189
SER A 190
SER A 195
VAL A 213
GLY A 216
GLY A 226
 None
 0.33A 2vinA-1ym0A:
36.0		 2vinA-1ym0A:
33.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W26_A_RIVA1001_1
(ACTIVATED FACTOR XA
HEAVY CHAIN)		 1ym0 FIBRINOTIC ENZYME
COMPONENT B
(Eisenia
fetida) 		8 / 12 ASP A 189
SER A 195
VAL A 213
TRP A 215
GLY A 216
GLY A 219
GLY A 226
TYR A 228
 None
 0.44A 2w26A-1ym0A:
36.5		 2w26A-1ym0A:
32.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DVAC59_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 1ym0 FIBRINOTIC ENZYME
COMPONENT B
(Eisenia
fetida) 		3 / 3 GLY A 197
GLY A 193
GLY A  43
 None
 0.41A 3bogC-1ym0A:
undetectable		 3bogC-1ym0A:
16.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GY3_A_PNTA246_0
(CATIONIC TRYPSIN)		 1ym0 FIBRINOTIC ENZYME
COMPONENT B
(Eisenia
fetida) 		8 / 11 HIS A  57
LEU A  99
ASP A 189
SER A 190
SER A 195
TRP A 215
GLY A 216
GLY A 226
 None
 0.43A 3gy3A-1ym0A:
36.0		 3gy3A-1ym0A:
39.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RXF_A_4APA9_1
(CATIONIC TRYPSIN)		 1ym0 FIBRINOTIC ENZYME
COMPONENT B
(Eisenia
fetida) 		6 / 6 SER A 190
SER A 195
VAL A 213
TRP A 215
GLY A 216
GLY A 226
 None
 0.30A 3rxfA-1ym0A:
14.1		 3rxfA-1ym0A:
39.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RXH_A_HSMA7_1
(CATIONIC TRYPSIN)		 1ym0 FIBRINOTIC ENZYME
COMPONENT B
(Eisenia
fetida) 		5 / 5 ASP A 189
SER A 190
SER A 195
VAL A 213
GLY A 226
 None
 0.30A 3rxhA-1ym0A:
36.3		 3rxhA-1ym0A:
39.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VQR_A_ACTA1002_0
(PUTATIVE
OXIDOREDUCTASE)		 1ym0 FIBRINOTIC ENZYME
COMPONENT B
(Eisenia
fetida) 		4 / 6 GLY A 226
VAL A 227
TRP A 215
THR A 184
 None
 1.22A 3vqrA-1ym0A:
undetectable		 3vqrA-1ym0A:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_A_0LIA1004_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 1ym0 FIBRINOTIC ENZYME
COMPONENT B
(Eisenia
fetida) 		5 / 11 VAL A 231
LEU A 209
GLY A 197
ILE A 181
VAL A  52
 None
 1.09A 3zosA-1ym0A:
undetectable
3zosB-1ym0A:
undetectable		 3zosA-1ym0A:
20.12
3zosB-1ym0A:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_B_PXLB300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 1ym0 FIBRINOTIC ENZYME
COMPONENT B
(Eisenia
fetida) 		5 / 9 ALA A  55
GLY A 196
VAL A  33
HIS A  57
CYH A  54
 None
 1.37A 4c5lB-1ym0A:
undetectable		 4c5lB-1ym0A:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_C_UEGC300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 1ym0 FIBRINOTIC ENZYME
COMPONENT B
(Eisenia
fetida) 		5 / 10 ALA A  55
GLY A 196
VAL A  33
HIS A  57
CYH A  54
 None
 1.38A 4c5lC-1ym0A:
undetectable		 4c5lC-1ym0A:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_D_UEGD300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 1ym0 FIBRINOTIC ENZYME
COMPONENT B
(Eisenia
fetida) 		5 / 10 ALA A  55
GLY A 196
VAL A  33
HIS A  57
CYH A  54
 None
 1.38A 4c5nD-1ym0A:
undetectable		 4c5nD-1ym0A:
17.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FU8_A_ACTA302_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 1ym0 FIBRINOTIC ENZYME
COMPONENT B
(Eisenia
fetida) 		4 / 5 HIS A  57
GLN A 192
GLY A 193
SER A 195
 None
 0.75A 4fu8A-1ym0A:
35.3		 4fu8A-1ym0A:
32.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G2Z_A_ID8A711_1
(LACTOTRANSFERRIN)		 1ym0 FIBRINOTIC ENZYME
COMPONENT B
(Eisenia
fetida) 		3 / 3 PRO A 124
TYR A 130
GLY A 211
 None
 0.74A 4g2zA-1ym0A:
undetectable		 4g2zA-1ym0A:
21.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HFP_D_15UD402_1
(PROTHROMBIN)		 1ym0 FIBRINOTIC ENZYME
COMPONENT B
(Eisenia
fetida) 		6 / 12 HIS A  57
LEU A  99
ASP A 189
VAL A 213
TRP A 215
GLY A 226
 None
 0.55A 4hfpD-1ym0A:
35.6		 4hfpD-1ym0A:
33.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y80_A_IREA402_0
(CYCLIN-G-ASSOCIATED
KINASE)		 1ym0 FIBRINOTIC ENZYME
COMPONENT B
(Eisenia
fetida) 		5 / 11 ASP A  86
SER A  87
ILE A 242
ASN A 245
ILE A  47
 None
 1.05A 5y80A-1ym0A:
undetectable		 5y80A-1ym0A:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BZO_C_FI8C1201_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 1ym0 FIBRINOTIC ENZYME
COMPONENT B
(Eisenia
fetida) 		5 / 12 ILE A 144
THR A 143
VAL A  67
SER A 195
VAL A 213
 None
 1.40A 6bzoC-1ym0A:
undetectable		 6bzoC-1ym0A:
12.06