SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ym5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOF_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 1ym5 HYPOTHETICAL 32.6
KDA PROTEIN IN
DAP2-SLT2 INTERGENIC
REGION
(Saccharomyces
cerevisiae) 		4 / 5 LEU A 197
PRO A 153
ALA A 165
ILE A 195
 None
 0.87A 2aofB-1ym5A:
undetectable		 2aofB-1ym5A:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_C_X2NC1479_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 1ym5 HYPOTHETICAL 32.6
KDA PROTEIN IN
DAP2-SLT2 INTERGENIC
REGION
(Saccharomyces
cerevisiae) 		5 / 12 PHE A  13
MET A 264
VAL A  12
ALA A 233
THR A 158
 None
 1.25A 2x2nC-1ym5A:
undetectable		 2x2nC-1ym5A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_D_X2ND1479_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 1ym5 HYPOTHETICAL 32.6
KDA PROTEIN IN
DAP2-SLT2 INTERGENIC
REGION
(Saccharomyces
cerevisiae) 		5 / 12 ILE A  26
PHE A  13
MET A 264
ALA A 233
THR A 158
 None
 1.33A 2x2nD-1ym5A:
undetectable		 2x2nD-1ym5A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_A_P1BA1478_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1ym5 HYPOTHETICAL 32.6
KDA PROTEIN IN
DAP2-SLT2 INTERGENIC
REGION
(Saccharomyces
cerevisiae) 		4 / 7 GLU A 131
ILE A 163
ALA A 266
ILE A 252
 None
 0.86A 2xkwA-1ym5A:
undetectable		 2xkwA-1ym5A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BPX_A_SALA257_1
(TRANSCRIPTIONAL
REGULATOR)		 1ym5 HYPOTHETICAL 32.6
KDA PROTEIN IN
DAP2-SLT2 INTERGENIC
REGION
(Saccharomyces
cerevisiae) 		4 / 8 ALA A 281
PHE A 123
THR A 115
ILE A 114
 None
 0.69A 3bpxA-1ym5A:
undetectable
3bpxB-1ym5A:
undetectable		 3bpxA-1ym5A:
18.12
3bpxB-1ym5A:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DEU_A_SALA305_1
(TRANSCRIPTIONAL
REGULATOR SLYA)		 1ym5 HYPOTHETICAL 32.6
KDA PROTEIN IN
DAP2-SLT2 INTERGENIC
REGION
(Saccharomyces
cerevisiae) 		4 / 7 THR A  53
ILE A  26
ILE A 292
THR A  48
 None
 0.82A 3deuA-1ym5A:
undetectable		 3deuA-1ym5A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IB1_A_IMNA701_1
(LACTOTRANSFERRIN)		 1ym5 HYPOTHETICAL 32.6
KDA PROTEIN IN
DAP2-SLT2 INTERGENIC
REGION
(Saccharomyces
cerevisiae) 		4 / 4 PRO A  73
THR A  72
GLY A 159
THR A 158
 None
 1.19A 3ib1A-1ym5A:
undetectable		 3ib1A-1ym5A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_C_URFC400_1
(URIDINE
PHOSPHORYLASE 1)		 1ym5 HYPOTHETICAL 32.6
KDA PROTEIN IN
DAP2-SLT2 INTERGENIC
REGION
(Saccharomyces
cerevisiae) 		4 / 8 THR A 172
GLY A 199
LEU A 166
ILE A 150
 None
 0.82A 3nbqC-1ym5A:
undetectable		 3nbqC-1ym5A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UM5_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1ym5 HYPOTHETICAL 32.6
KDA PROTEIN IN
DAP2-SLT2 INTERGENIC
REGION
(Saccharomyces
cerevisiae) 		5 / 10 ILE A 288
VAL A  10
PHE A   7
ILE A  44
THR A 286
 None
 1.13A 3um5A-1ym5A:
undetectable		 3um5A-1ym5A:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UM5_B_CP6B709_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1ym5 HYPOTHETICAL 32.6
KDA PROTEIN IN
DAP2-SLT2 INTERGENIC
REGION
(Saccharomyces
cerevisiae) 		5 / 10 ILE A 288
VAL A  10
PHE A   7
ILE A  44
THR A 286
 None
 1.14A 3um5B-1ym5A:
undetectable		 3um5B-1ym5A:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJF_B_C2FB300_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 1ym5 HYPOTHETICAL 32.6
KDA PROTEIN IN
DAP2-SLT2 INTERGENIC
REGION
(Saccharomyces
cerevisiae) 		5 / 12 GLU A 223
PHE A 180
ASP A 224
ASN A  21
GLY A 255
 None
 1.44A 4djfB-1ym5A:
undetectable		 4djfB-1ym5A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_B_SAMB2409_0
(RNA-DIRECTED RNA
POLYMERASE L)		 1ym5 HYPOTHETICAL 32.6
KDA PROTEIN IN
DAP2-SLT2 INTERGENIC
REGION
(Saccharomyces
cerevisiae) 		5 / 12 THR A 158
GLY A 228
GLY A 230
THR A  54
ALA A  80
 None
 1.11A 4uckB-1ym5A:
undetectable		 4uckB-1ym5A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_B_CHDB102_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 1ym5 HYPOTHETICAL 32.6
KDA PROTEIN IN
DAP2-SLT2 INTERGENIC
REGION
(Saccharomyces
cerevisiae) 		5 / 11 LEU A 166
GLU A 254
ALA A 233
LEU A 234
TYR A 237
 None
 1.00A 4wg0B-1ym5A:
undetectable
4wg0C-1ym5A:
undetectable
4wg0D-1ym5A:
undetectable		 4wg0B-1ym5A:
4.14
4wg0C-1ym5A:
4.14
4wg0D-1ym5A:
4.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_D_CHDD102_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 1ym5 HYPOTHETICAL 32.6
KDA PROTEIN IN
DAP2-SLT2 INTERGENIC
REGION
(Saccharomyces
cerevisiae) 		5 / 11 LEU A 166
GLU A 254
ALA A 233
LEU A 234
TYR A 237
 None
 1.04A 4wg0D-1ym5A:
undetectable
4wg0E-1ym5A:
undetectable
4wg0F-1ym5A:
undetectable		 4wg0D-1ym5A:
4.14
4wg0E-1ym5A:
4.14
4wg0F-1ym5A:
4.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_F_CHDF103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 1ym5 HYPOTHETICAL 32.6
KDA PROTEIN IN
DAP2-SLT2 INTERGENIC
REGION
(Saccharomyces
cerevisiae) 		5 / 11 LEU A 166
GLU A 254
ALA A 233
LEU A 234
TYR A 237
 None
 1.03A 4wg0F-1ym5A:
undetectable
4wg0G-1ym5A:
undetectable
4wg0H-1ym5A:
undetectable		 4wg0F-1ym5A:
4.14
4wg0G-1ym5A:
4.14
4wg0H-1ym5A:
4.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_G_CHDG103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 1ym5 HYPOTHETICAL 32.6
KDA PROTEIN IN
DAP2-SLT2 INTERGENIC
REGION
(Saccharomyces
cerevisiae) 		5 / 11 ALA A 233
LEU A 234
TYR A 237
GLU A 254
LEU A 166
 None
 1.00A 4wg0E-1ym5A:
undetectable
4wg0F-1ym5A:
undetectable
4wg0G-1ym5A:
undetectable		 4wg0E-1ym5A:
4.14
4wg0F-1ym5A:
4.14
4wg0G-1ym5A:
4.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_I_CHDI103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 1ym5 HYPOTHETICAL 32.6
KDA PROTEIN IN
DAP2-SLT2 INTERGENIC
REGION
(Saccharomyces
cerevisiae) 		5 / 11 ALA A 233
LEU A 234
TYR A 237
GLU A 254
LEU A 166
 None
 1.10A 4wg0G-1ym5A:
undetectable
4wg0H-1ym5A:
undetectable
4wg0I-1ym5A:
undetectable		 4wg0G-1ym5A:
4.14
4wg0H-1ym5A:
4.14
4wg0I-1ym5A:
4.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBQ_A_ACTA605_0
(SERUM ALBUMIN)		 1ym5 HYPOTHETICAL 32.6
KDA PROTEIN IN
DAP2-SLT2 INTERGENIC
REGION
(Saccharomyces
cerevisiae) 		4 / 6 TYR A 141
HIS A 192
GLY A 194
ASN A 190
 None
 1.13A 4zbqA-1ym5A:
undetectable		 4zbqA-1ym5A:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0O_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 1ym5 HYPOTHETICAL 32.6
KDA PROTEIN IN
DAP2-SLT2 INTERGENIC
REGION
(Saccharomyces
cerevisiae) 		3 / 3 ALA A  90
GLN A   9
THR A 286
 None
 0.71A 5n0oA-1ym5A:
undetectable		 5n0oA-1ym5A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_D_C2FD3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 1ym5 HYPOTHETICAL 32.6
KDA PROTEIN IN
DAP2-SLT2 INTERGENIC
REGION
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 255
LYS A 259
LEU A 238
GLY A 230
PHE A 215
 None
 1.08A 5vooD-1ym5A:
undetectable		 5vooD-1ym5A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_A_QPSA602_1
(-)		 1ym5 HYPOTHETICAL 32.6
KDA PROTEIN IN
DAP2-SLT2 INTERGENIC
REGION
(Saccharomyces
cerevisiae) 		5 / 12 ASP A  11
ASN A  21
GLU A 254
PRO A 225
GLY A 255
 None
 1.44A 6gnfA-1ym5A:
undetectable		 6gnfA-1ym5A:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_C_QPSC602_2
(-)		 1ym5 HYPOTHETICAL 32.6
KDA PROTEIN IN
DAP2-SLT2 INTERGENIC
REGION
(Saccharomyces
cerevisiae) 		5 / 12 ASP A  11
ASN A  21
GLU A 254
PRO A 225
GLY A 255
 None
 1.45A 6gnfC-1ym5A:
undetectable		 6gnfC-1ym5A:
18.51