SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1yns'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A29_A_TFPA153_1
(CALMODULIN)		 1yns E-1 ENZYME
(Homo
sapiens) 		5 / 8 ILE A 207
LEU A  14
GLU A 216
ALA A 220
VAL A 225
 None
None
MG  A1258 ( 4.6A)
None
None
 1.14A 1a29A-1ynsA:
undetectable		 1a29A-1ynsA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KI7_A_ID2A1_0
(THYMIDINE KINASE)		 1yns E-1 ENZYME
(Homo
sapiens) 		5 / 12 GLU A  41
ILE A  35
MET A 117
ALA A 120
GLU A  37
 None
 1.47A 1ki7A-1ynsA:
undetectable		 1ki7A-1ynsA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O76_A_CAMA1420_0
(CYTOCHROME P450-CAM)		 1yns E-1 ENZYME
(Homo
sapiens) 		5 / 10 THR A 107
LEU A 110
VAL A  97
ASP A  66
VAL A  73
 None
 1.28A 1o76A-1ynsA:
undetectable		 1o76A-1ynsA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CP4_A_CAMA416_0
(CYTOCHROME P450-CAM)		 1yns E-1 ENZYME
(Homo
sapiens) 		5 / 10 THR A 107
LEU A 110
VAL A  97
ASP A  66
VAL A  73
 None
 1.27A 2cp4A-1ynsA:
undetectable		 2cp4A-1ynsA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P73_A_ACTA275_0
(MHC RFP-Y CLASS I
ALPHA CHAIN)		 1yns E-1 ENZYME
(Homo
sapiens) 		3 / 3 ILE A 172
VAL A 136
ARG A 140
 None
 0.64A 3p73A-1ynsA:
undetectable		 3p73A-1ynsA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1475_0
(MJ0495-LIKE PROTEIN)		 1yns E-1 ENZYME
(Homo
sapiens) 		4 / 8 ASP A 171
ILE A 172
PHE A 164
VAL A 135
 None
 0.82A 4ac9C-1ynsA:
2.2		 4ac9C-1ynsA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1475_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 1yns E-1 ENZYME
(Homo
sapiens) 		4 / 8 ASP A 171
ILE A 172
PHE A 164
VAL A 135
 None
 0.80A 4acbC-1ynsA:
3.4		 4acbC-1ynsA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_B_ADNB501_1
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 1yns E-1 ENZYME
(Homo
sapiens) 		5 / 12 ASP A 212
VAL A 213
SER A 154
GLY A  19
PHE A  32
 MG  A1258 (-2.6A)
None
HPO  A1261 (-2.3A)
MG  A1258 ( 4.4A)
HPO  A1261 (-4.6A)
 1.24A 4pevB-1ynsA:
4.2		 4pevB-1ynsA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R3A_A_RBFA402_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 1yns E-1 ENZYME
(Homo
sapiens) 		4 / 8 GLU A  36
VAL A  27
LEU A  31
GLY A 115
 None
HPO  A1261 ( 4.8A)
None
None
 0.89A 4r3aA-1ynsA:
undetectable		 4r3aA-1ynsA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_B_CVIB602_0
(ACETYLCHOLINESTERASE)		 1yns E-1 ENZYME
(Homo
sapiens) 		4 / 8 THR A 211
LEU A 210
THR A  21
VAL A 139
 None
 1.27A 5ov9B-1ynsA:
undetectable		 5ov9B-1ynsA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_O_CHDO302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 1yns E-1 ENZYME
(Homo
sapiens) 		5 / 11 GLY A 155
GLY A 115
GLN A 114
THR A 107
THR A 108
 HPO  A1261 ( 3.8A)
None
None
None
None
 1.24A 5x1bG-1ynsA:
0.0
5x1bN-1ynsA:
0.0
5x1bO-1ynsA:
0.0		 5x1bG-1ynsA:
13.79
5x1bN-1ynsA:
17.94
5x1bO-1ynsA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA504_1
(CYTOCHROME P450 2C9)		 1yns E-1 ENZYME
(Homo
sapiens) 		4 / 8 ILE A 151
PRO A  23
THR A  22
PHE A 131
 None
 1.05A 5x23A-1ynsA:
undetectable		 5x23A-1ynsA:
20.26