SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ynw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_A_ACTA3001_0
(BETA-CARBONIC
ANHYDRASE)		 1ynw RETINOIC ACID
RECEPTOR RXR-ALPHA
(Homo
sapiens) 		4 / 8 CYH B 238
ASP B 240
CYH B 252
GLY B 254
 ZN  B 350 (-2.4A)
None
ZN  B 350 (-2.5A)
None
 0.84A 1ekjA-1ynwB:
undetectable
1ekjB-1ynwB:
undetectable		 1ekjA-1ynwB:
13.96
1ekjB-1ynwB:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_C_ACTC3004_0
(BETA-CARBONIC
ANHYDRASE)		 1ynw VITAMIN D3 RECEPTOR
(Homo
sapiens) 		4 / 6 CYH A  24
ASP A  29
VAL A  26
GLY A  43
 ZN  A 150 (-2.4A)
None
ZN  A 150 ( 4.4A)
None
 0.97A 1ekjC-1ynwA:
undetectable
1ekjD-1ynwA:
undetectable		 1ekjC-1ynwA:
18.81
1ekjD-1ynwA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_C_ACTC3007_0
(BETA-CARBONIC
ANHYDRASE)		 1ynw VITAMIN D3 RECEPTOR
(Homo
sapiens) 		4 / 6 CYH A  24
ASP A  29
VAL A  26
GLY A  43
 ZN  A 150 (-2.4A)
None
ZN  A 150 ( 4.4A)
None
 0.96A 1ekjC-1ynwA:
undetectable
1ekjD-1ynwA:
undetectable		 1ekjC-1ynwA:
18.81
1ekjD-1ynwA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_G_ACTG3002_0
(BETA-CARBONIC
ANHYDRASE)		 1ynw RETINOIC ACID
RECEPTOR RXR-ALPHA
(Homo
sapiens) 		4 / 8 CYH B 238
ASP B 240
CYH B 252
GLY B 254
 ZN  B 350 (-2.4A)
None
ZN  B 350 (-2.5A)
None
 0.82A 1ekjG-1ynwB:
undetectable
1ekjH-1ynwB:
undetectable		 1ekjG-1ynwB:
13.96
1ekjH-1ynwB:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y05_A_RALA802_1
(PROSTAGLANDIN
REDUCTASE 1)		 1ynw RETINOIC ACID
RECEPTOR RXR-ALPHA
(Homo
sapiens) 		4 / 7 VAL B 249
TYR B 250
GLY B 239
ASP B 280
 None
 0.86A 2y05A-1ynwB:
undetectable
2y05B-1ynwB:
undetectable		 2y05A-1ynwB:
14.67
2y05B-1ynwB:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CKK_A_SAMA301_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 1ynw VITAMIN D3 RECEPTOR
(Homo
sapiens) 		5 / 12 GLY A  28
GLY A  25
ILE A  68
ARG A  83
ASN A  72
 None
 1.16A 3ckkA-1ynwA:
undetectable		 3ckkA-1ynwA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DBY_A_ACTA610_0
(SERUM ALBUMIN)		 1ynw RETINOIC ACID
RECEPTOR RXR-ALPHA
(Homo
sapiens) 		3 / 3 TYR B 247
LYS B 260
LYS B 256
 None
 0.89A 5dbyA-1ynwB:
undetectable		 5dbyA-1ynwB:
9.09